Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Blarcamesine hydrochloride (AVex-73 hydrochloride) 是一个sigma-1受体激动剂,IC50值为 860 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 228 | 现货 | ||
2 mg | ¥ 319 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 872 | 现货 | ||
25 mg | ¥ 1,570 | 现货 | ||
50 mg | ¥ 2,610 | 现货 | ||
100 mg | ¥ 3,890 | 现货 | ||
500 mg | ¥ 8,570 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 556 | 现货 |
产品描述 | Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). |
靶点活性 | σ1:860 nM |
体内活性 | The pretreatment of Anavex 2-73 (1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Anavex 2-73 (>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Anavex 2-73 (1?mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Anavex 2-73 (0.1/1?mg/kg). Seven days after injections, Anavex 2-73 attenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1?mg/kg)[2]. |
动物实验 | Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures. |
别名 | Anavex 2-73, AVex-73 hydrochloride, AE-37 hydrochloride |
分子量 | 317.85 |
分子式 | C19H24ClNO |
CAS No. | 195615-84-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37.5 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Blarcamesine hydrochloride 195615-84-0 GPCR/G Protein Sigma receptor AE37 Hydrochloride Anavex 2-73 AVex-73 hydrochloride AE-37 Hydrochloride AE-37 hydrochloride Inhibitor AVex-73 Hydrochloride Blarcamesine Blarcamesine Hydrochloride inhibit AE 37 Hydrochloride Sigma Receptor inhibitor