Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N2-methylguanine (N2-methylguanine) 是一种在人体体液中发现的内源性甲基化核苷,是一种修饰的核苷。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 518 | 现货 | ||
5 mg | ¥ 1,250 | 现货 | ||
10 mg | ¥ 1,990 | 现货 | ||
25 mg | ¥ 3,370 | 现货 | ||
50 mg | ¥ 4,880 | 现货 | ||
100 mg | ¥ 6,990 | 现货 |
产品描述 | N2-methylguanine (N2-methylguanine) is an endogenous methylated nucleoside found in human fluids and a modified nucleoside. |
体外活性 | N2-methylguanine is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of N2-methylguanine in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[1]. N2-methylguanine is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of N2-methylguanine substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[2]. |
别名 | 6-羟基-2-氨甲基嘌呤 |
分子量 | 165.15 |
分子式 | C6H7N5O |
CAS No. | 10030-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1 mg/mL (insoluble or slightly soluble)
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
N2-methylguanine 10030-78-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology DNA/RNA Synthesis Endogenous Metabolite Antibacterial 2(Methylamino)1Hpurin6(7H)one 6-羟基-2-氨甲基嘌呤 2 (Methylamino) 1H purin 6(7H) one Bacterial Inhibitor inhibit inhibitor