HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product Name	CAS No.	Purity
TN1670	Ganodermanondiol 灵芝酮二醇	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
T12420	Pentosan Polysulfate 化合物 T12420	37300-21-3	98%
T12420	Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cysti...
TN4911	Rhuscholide A 化合物 TN4911	944804-58-4	98%
TN4911	Rhuscholide A possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40.
TN5012	Shizukaol C 化合物 TN5012	142279-41-2	98%
TN5012	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. 2. Shizukaol C has significant cytotoxicit...
T16555	PNU-103017 化合物 T16555	166335-18-8	98%
T16555	PNU-103017 is an inhibitor of HIV protease.
TN1302	6,8-Diprenylorobol 化合物6,8-Diprenylorobol	66777-70-6	98%
TN1302	6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected in...
TN4264	Isoapetalic acid 化合物 TN4264	34366-34-2	98%
TN4264	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell ...
T39264L	Cyclotriazadisulfonamide hydrochloride 化合物 Cyclotriazadisulfonamide hydrochloride	392287-03-5	98%
T39264L	Cyclotriazadisulfonamide hydrochloride 是 CD4 靶向 HIV 进入的选择性抑制剂，并以信号肽依赖性方式抑制人 CD4 共翻译易位进入 ER 腔。
TN1852	Lancifodilactone F 化合物 TN1852	850878-47-6	98%
TN1852	Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a ...
TN4835	Przewalskin 化合物 TN4835	119400-87-2	98%
TN4835	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
T10714	CCR5 antagonist 1 化合物 T10714	716354-86-8	98%
T10714	CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T30791	Censavudine 化合物Censavudine	634907-30-5	98%
T30791	Censavudine (OBP-601) 是一种核苷类似物，是一种核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂，可用于预防和治疗人类免疫缺陷病毒 1 （HIV-1）。Censavudine 对 HIV-2 和 HIV-1 具有抑制作用， EC50 范围分别为 30-81 n...
TMA1012	Ganoderiol F 化合物 TMA1012	114567-47-4	98%
TMA1012	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
T12420L	Pentosan Polysulfate Sodium (W/W 43%) 化合物 T12420L	140207-93-8	98%
T12420L	Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitia...
TN4934	Salaspermic acid 化合物 TN4934	71247-78-4	98%
TN4934	Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
T13796	Nigranoic acid 化合物 T13796	39111-07-4	98%
T13796	Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
TQ0073	Andropanolide 穿心莲内酯	869807-57-8	98%
TQ0073	Andropanolide 是一种来自穿心莲的二帖类化合物，具有抗HIV、抗疟和抗癌活性，对 Lipopolysaccharides (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的过量产生有抑制作用。
TN3444	Aristolactam BII 化合物 TN3444	53948-09-7	98%
TN3444	Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effect...
T11189	Emtricitabine S-oxide 化合物 T11189	152128-77-3	98%
T11189	Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine su...
T10111	3-Deazaadenosine hydrochloride 化合物3-Deazaadenosine hydrochloride	86583-19-9	99.99%
T10111	3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂，Ki 值为 3.9 µM。它具有抗炎、抗增殖和抗 HIV 活性。