HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product Name	CAS No.	Purity
T16973	TAK-220 化合物 T16973	333994-00-6	98%
T16973	TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively...
TN3704	Coronalolide 化合物 TN3704	268214-51-3	98%
TN3704	Coronalolide shows significant cytotoxic activities in P-388 cell line, it also displays significant anti-HIV activities in the HIV-1RT assay. Coronalolide and c...
T14831	Bryostatin 1 苔藓抑素1	83314-01-6	98%
T14831	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
T15683	L-689502 化合物 T15683	138483-63-3	98%
T15683	L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 5-羟基-7,8-二甲氧基黄烷酮	113981-49-0	98%
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的，具有抗炎活性。
TN4705	Oleoside 木犀榄苷	178600-68-5	98%
TN4705	Oleoside 可从油橄榄和Zizyphus lotus L.树枝中提取，可能用于抑制HIV-1蛋白酶。
TN4605	Myriceric acid B 化合物 TN4605	55497-79-5	98%
TN4605	Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
TN5191	Tsugafolin 化合物 TN5191	66568-97-6	98%
TN5191	Tsugafolin has weak anti-HIV activity.
TN1194	16beta,17-Dihydroxy-ent-kaurane-19-oic acid ENT-16Α17-二羟基贝壳杉烷-18-羧酸	74365-74-5	98%
TN1194	16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...
T10111L	3-Deazaadenosine 3-脱氮腺苷	6736-58-9	98%
T10111L	3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and it has anti-inflammatory, anti-proliferative and anti-HIV activity...
T22468	1-Deoxymannojirimycin hydrochloride 1-甘露糖野尻霉素盐酸盐	73465-43-7	98%
T22468	1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 化合物 TN5133	125537-92-0	98%
TN5133	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
TN1348	8-Prenylluteone 8-异戊烯基羽扇豆异黄酮	125002-91-7	98%
TN1348	8-Prenylluteone can potently inhibit HIV-1 PR activity.
TN1708	Gomisin M2 五味子脂素 M2	82425-45-4	98%
TN1708	Gomisin M2 is an anti-HIV agent.
TN3152	6-Acetonyldihydrochelerythrine 化合物 TN3152	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
T10928	Cytochalasin A 细胞松弛素A	14110-64-6	98%
T10928	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
TN4584	Morolic acid 化合物 TN4584	559-68-2	98%
TN4584	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
T14559	BI 224436 化合物 T14559	1155419-89-8	98%
T14559	BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
TN3777	Daurichromenic acid 化合物 TN3777	82003-90-5	98%
TN3777	Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
T16112	ML67-33 化合物 T16112	1443290-89-8	98%
T16112	ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...