store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Censavudine (OBP-601) 是一种核苷类似物,是一种核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂,可用于预防和治疗人类免疫缺陷病毒 1 (HIV-1)。Censavudine 对 HIV-2 和 HIV-1 具有抑制作用, EC50 范围分别为 30-81 nM 和 450-890 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 4,190 | 5日内发货 | ||
25 mg | ¥ 19,100 | 待询 | ||
50 mg | ¥ 24,900 | 待询 | ||
100 mg | ¥ 35,500 | 待询 |
产品描述 | Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively. |
靶点活性 | HIV-2:30-81 nM (EC50), HIV-2 (ROD9):74 nM(EC50), HIV-1:450-890 nM, HIV-1NL4-3:890 nM(EC50) |
体外活性 |
In a single-cycle assay, BMS-986001 demonstrates greater activity against HIV-2ROD9 compared to HIV-1NL4-3. The mean EC50s for BMS-986001 are 74 nM for HIV-2ROD9 and 890 nM for HIV-1NL4-3. In a 4-day infection of an immortalized T cell line (CEMss), HIV-2ROD9 exhibits greater sensitivity to BMS-986001, with a mean EC50 of 0.14 nM, which is 30-fold lower than the EC50 for HIV-1NL4-3 (4.2 nM)[2]. Furthermore, BMS-986001 maintains full activity against HIV-2 variants with genomes encoding the single amino acid changes K65R and Q151M in reverse transcriptase[2]. |
体内活性 | Comparing the pharmacokinetic parameters of Censavudine (BMS-986001) at doses ranging from 100 to 750 mg/kg, the dried blood spot (DBS) assay and plasma assay are utilized. Across all dose groups in rats, the ratios of AUC(0-24 h) and Cmax for BMS-986001 in DBS compared to plasma remain consistent at 0.83-0.91 and 0.81-0.97, respectively. The Tmax in rat DBS and plasma also consistently occurs at about 1 h[1]. |
别名 | OBP 601, BMS 986001, BMS-986001, OBP601, BMS986001, OBP-601 |
分子量 | 248.23 |
分子式 | C12H12N2O4 |
CAS No. | 634907-30-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mg/mL (20.14 mM), Sonication is recommended.
DMSO: 45 mg/mL (181.28 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.0285 mL | 20.1426 mL | 40.2852 mL | 100.713 mL |
5 mM | 0.8057 mL | 4.0285 mL | 8.057 mL | 20.1426 mL | |
10 mM | 0.4029 mL | 2.0143 mL | 4.0285 mL | 10.0713 mL | |
20 mM | 0.2014 mL | 1.0071 mL | 2.0143 mL | 5.0357 mL | |
DMSO | 50 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 2.0143 mL |
100 mM | 0.0403 mL | 0.2014 mL | 0.4029 mL | 1.0071 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Censavudine 634907-30-5 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase OBP 601 BMS 986001 BMS-986001 OBP601 BMS986001 OBP-601 Inhibitor inhibitor inhibit