JAK

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product Name	CAS No.	Purity
T79235	JAK-IN-30 化合物 JAK-IN-30	2891469-99-9	98%
T79235	JAK-IN-30（化合物31）是一种具有水溶性的JAK抑制剂，对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症（DED）的潜在药物而备受关注。
T79581	JAK2-IN-9 化合物 JAK2-IN-9	2568842-26-0	98%
T79581	JAK2-IN-9（Compound A8）是一款选择性JAK2抑制剂（IC50：5 nM），能够抑制JAK2、STAT3和STAT5的磷酸化，并显示出代谢稳定性。此外，JAK2-IN-9能够诱导细胞凋亡（apoptosis），适用于骨髓增生性肿瘤（MPN）的研究。
T79608	DPP 化合物 DPP	2668267-47-6	98%
T79608	DPP，一种含紫檀芪衍生轴向配体的铂(IV)络合物，能够抑制乳腺癌(BC)细胞的JAK2-STAT3通路并显示出抗增殖特性。它通过激活caspase-3和裂解聚ADP-核糖聚合酶诱导细胞凋亡(apoptosis)，同时促进树突状细胞成熟及抗原呈现功能，并已证明体内具有安全性。
T79609	STAT3-IN-18 化合物 STAT3-IN-18	2668267-41-0	98%
T79609	STAT3-IN-18 (compound SPP)，一种带紫檀芪衍生轴向配体的铂(IV)络合物，能抑制乳腺癌(BC)细胞的JAK2-STAT3通路，显示出抗增殖活性。它激活caspase-3和裂解聚ADP-核糖聚合酶，诱导apoptosis。此外，STAT3-IN-18可促进树突状细胞成熟与抗原呈递，体现了良好的体内安...
T79807	JAK kinase-IN-1 化合物 JAK kinase-IN-1	2698389-43-2	98%
T79807	JAKkinase-IN-1 (Example 1)为一种JAK抑制剂，其对TYK2、JAK1、JAK2和JAK3的抑制IC50值分别为4.2 nM、32 nM、27 nM及3473 nM。
T79882	JAK-IN-31 化合物 JAK-IN-31	2597016-88-9	98%
T79882	JAK-IN-31（实施例 75）作为JAK抑制剂，对JAK1、JAK2、JAK3及Tyk2的IC50值分别为≤0.01µM、≤0.01µM、0.01-0.1µM、≤0.01µM，适用于癌症研究领域。
T81331	QL-1200186 化合物 QL-1200186	2848664-42-4	98%
T81331	QL-1200186为具备口服活性与选择性的TYK2抑制剂。经口服后，该药剂量依赖性抑制因interleukin-12刺激所诱导的interferon-γ产生，并在银屑病模型小鼠中显著改善皮肤病变状况。
T82017	JAK-IN-34 化合物 JAK-IN-34	2068766-90-3	98%
T82017	JAK-IN-34 对JAKs具有有效抑制作用，其IC50值分别针对JAK1、JAK2、JAK3、TYK2为0.40、0.83、2.10、1.95 nM 。此外，JAK-IN-34 能够降低关节肿胀，并展现出良好的安全性。
T82018	JAK-IN-33 化合物 JAK-IN-33		98%
T82018	JAK-IN-33（化合物3（R））为一种JAK抑制剂。
T83218	ABBV-712 化合物 ABBV-712	2368945-27-9	98%
T83218	ABBV-712为选择性酪氨酸激酶 2 (TYK2) 抑制剂，IC50值为0.195 μM，关键作用于自身免疫性疾病。
T9814	JAK3/BTK-IN-1 化合物JAK3/BTK-IN-1	2674036-91-8	98%
T9814	JAK3/BTK- in -1是一种特异性靶向和抑制Janus 激酶3 (JAK3)和布鲁顿酪氨酸激酶(BTK）的JAK3/BTK 双重抑制剂，BTK 和 JAK3 是自身免疫性疾病的两个重要靶点。JAK3/BTK- in -1同时抑制 BTK/JAK3 信号通路表现出协同效应。 JAK3/BTK- in -1是治疗免...
T15606	JAK1-IN-4 化合物 T15606	2091134-35-7	98%
T15606	JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NC...
TN2511	Britannilactone diacetate 化合物 TN2511	1286694-67-4	98%
TN2511	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T11721L	JDTic dihydrochloride 化合物 T11721L	785835-79-2	98%
T11721L	JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T11708	JAK2-IN-4 化合物 T11708	1438284-00-4	98%
T11708	JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T15037	Momelotinib Mesylate 化合物 T15037	1056636-07-7	98%
T15037	Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
T11714	JBJ-04-125-02 化合物 T11714	2060610-53-7	98%
T11714	JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. JBJ-04-125-02 is a potent, muta...
TN2002	Obovatol 和厚朴新酚	83864-78-2	98%
TN2002	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...