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Search Results for " tubulin-inhibitory "

16

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1753	D-64131	Microtubule Associated	Cytoskeletal Signaling
	D64131 是一种微管蛋白聚合抑制剂，IC50 值为 0.53 μM。它具有抗丝分裂活性，可用于癌症研究。
T11917	Lys-SMCC-DM1 Lys-Nε-MCC-DM1	Microtubule Associated	Cytoskeletal Signaling
	DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T61242	Tubulin inhibitor 12
	Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promising candidate for the treatment of cancer [1].
T61459	Tubulin inhibitor 19
	Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].
T39139	PARP1-IN-6 PARP1-IN-6
	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively.
T72719	Tubulin/MMP-IN-2
	Tubulin/MMP-IN-2是一种针对微管蛋白和基质金属蛋白酶的双重抑制剂，能有效抑制微管蛋白聚合并触发细胞凋亡。该化合物对MMP-2、MMP-3及MMP-9展现出明显的抑制效果，其IC50值分别为24.95 μM、31.60 μM与22.37 μM。Tubulin/MMP-IN-2主要应用于癌症研究领域。
T72449	Tubulin inhibitor 31
	Tubulin inhibitor 31, 以IC50值4 µM的效力，是一种高效的微管蛋白(Tubulin)抑制剂，具有显著的抗增殖活性，并能抑制HUVEC的迁移。
T63513	Antitumor agent-71
	Antitumor Agent-71 是一种抗肿瘤化合物，对微管蛋白 (tubulin) 的聚集表现出抑制作用。Antitumor Agent-71 拥有抗增殖作用，对肿瘤细胞系的 IC50值范围为3.98-15.70 μM。
T61433	HDAC1-IN-5
	HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and α-tubulin, leading to the activation of caspase 3 and induction of apoptosis. Additionally, HDAC1-IN-5 binds with DNA, causing chromatin damage. Furthermore, it demonstrated strong inhibitory activity against tumor growth in xenograft mice. [1]
T40348	TTBK1-IN-1 TTBK1-IN-1
	TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activity against TTBK1. This compound holds great promise for advancing research in Alzheimer's disease and other tauopathies.
T22631	Dolastatin 10 trifluoroacetate	Others	Others
	Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it
T63696	HDAC-IN-9
	HDAC-IN-9 是有效的、选择性的 tubulin 和 HDAC 双重抑制剂。HDAC-IN-9 对 A549 细胞的侵袭和迁移表现出抑制作用。HDAC-IN-9 在体外和体内均表现出有效的抗肿瘤和抗血管生成活性。
T71252	PC-046
	PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di...
T61696	EGFR-IN-57
	EGFR-IN-57 (Compound 25a) 是一种有效的、具有口服活性的EGFR-TK 抑制剂，IC50值为 0.054 μM。EGFR-IN-57 也抑制VEGFR-2、CK2α、topoisomerase IIβ和tubulin polymerization，IC50值分别为 0.087、0.171、0.13 和 3.61 μM。EGFR-IN-57 诱导细胞 G2/M 和 pre-G1 期周期阻滞，诱导癌细胞凋亡 (apoptosis)。
T73581	HI5
	HI5 是一种有效的微管蛋白 (tublin)和IDO 抑制剂，对 HeLa 细胞的IC50为 70 nM。HI5 抑制IDO 的表达，减少犬尿氨酸的产生，从而刺激 T 细胞活化和增殖。HI5 对 HeLa 细胞可抑制微管蛋白聚合和细胞迁移，引起 G2/M 期阻滞，同时通过线粒体依赖性凋亡途径诱导细胞凋亡 (apoptosis) 并引起反应性氧化应激。HI5 可用于抗癌研究。

化合物

Cat.No: T1753

Target: Microtubule Associated

Cat.No: T11917

Synonym: Lys-Nε-MCC-DM1

Target: Microtubule Associated

Tubulin polymerization-IN-47

Cat.No: T77651

Target: Microtubule Associated

Tubulin inhibitor 12

Cat.No: T61242

Tubulin inhibitor 19

Cat.No: T61459

Cat.No: T39139

Synonym: PARP1-IN-6

Tubulin/MMP-IN-2

Cat.No: T72719

Tubulin inhibitor 31

Cat.No: T72449

Antitumor agent-71

Cat.No: T63513

Cat.No: T61433

Cat.No: T40348

Synonym: TTBK1-IN-1

Dolastatin 10 trifluoroacetate

Cat.No: T22631

Target: Others

Cat.No: T63696

Cat.No: T71252

Cat.No: T61696

Cat.No: T73581

Cat. No.	Product Name	Target	Signaling Pathways
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 与微管蛋白结合并抑制微管的形成，从而抑制癌细胞的有丝分裂。 Vincristine 可用作微管去稳定剂，用于研究治疗血液系统癌症，如白血病和淋巴瘤以及儿童肉瘤的相关研究。

天然产物

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

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