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Search Results for " thiol "

156

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8483	Cysteine thiol probe Methyl (4-bromobenzoyl)-L-cysteinate	Others	Others
	Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) 是基于硫醇的探针，旨在标记亲电子的天然产物。它能够结合基于烯酮，β-内酰胺和 β-内酯的亲电子代谢物。它具有理想药效团探针的每个特征，并具有发色团。
TQ0133	Amifostine thiol dihydrochloride WR 1065,硫代乙基氨基乙基胺盐酸盐	p53	Apoptosis
	Amifostine thiol dihydrochloride (WR 1065) 可通过 JNK 依赖性信号通路激活 p53。它还可以保护正常组织免受某些抗癌药物的毒性作用。
T40746	m-PEG7-thiol m-PEG7-thiol
	m-PEG7-thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38701	Thiol-C9-PEG4 Thiol-C9-PEG4
	Thiol-C9-PEG4 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38703	Thiol-C9-PEG7 Thiol-C9-PEG7
	Thiol-C9-PEG7 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38702	Thiol-C9-PEG5 Thiol-C9-PEG5
	Thiol-C9-PEG5 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38756	Thiol-C10-amide-PEG8 Thiol-C10-amide-PEG8
	Thiol-C10-amide-PEG8 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40824	Thiol-C9-PEG4-acid Thiol-C9-PEG4-acid
	Thiol-C9-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T23728	Aminooxy-PEG3-C2-thiol Aminooxy-PEG3-thiol HCl,Aminooxy-PEG3-thiol HCl salt
	Aminooxy-PEG3-thiol HCl salt is an Aminooxy PEG Linker. PEG Linkers may be useful in the development of antibody-drug conjugates and drug delivery methods.
T38821	Thiol-PEG2-t-butyl ester Thiol-PEG2-t-butyl ester
	Thiol-PEG2-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17078	Thiol-PEG4-Boc Thiol-PEG4-t-butyl ester	Others	Others
	Thiol-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17075	Thiol-PEG3-Boc Thiol-PEG3-t-butyl ester	Others	Others
	Thiol-PEG3-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T34789	Thiol-PEG3-NHBoc t-Boc-N-amido-PEG3-thiol
	t-Boc-N-amido-PEG3-thiol is a PEG derivative containing a Boc-protected amino group and a thiol group.
T37538	Amifostine thiol
	Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3].
T20973	Thiol-C2-PEG2-OH Thiol-PEG3-alcohol,HS-PEG3-OH
	Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
T18184	m-PEG3-SH M-PEG3-Thiol,2-(2-(2-Methoxyethoxy)Ethoxy)Ethanethiol	Others; PROTAC Linker	Others; PROTAC
	m-PEG3-SH (M-PEG3-Thiol) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T12776L	Real Thiol	Others	Others
	Real Thiol, a reversible reaction-based fluorescent probe, can quantitatively monitor the real-time glutathione dynamics in living cells.
T16634	Propargyl-PEG4-thiol	Others	Others
	Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18836	Thiol-PEG12-acid	Others	Others
	Thiol-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T30477	Bis-PEG5-thiol
	Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.
T18144	m-PEG12-Thiol	Others	Others
	m-PEG12-Thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17077	Thiol-PEG4-acid	Others	Others
	Thiol-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15917	m-PEG6-thiol	Others	Others
	m-PEG6-thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18600	VH032 thiol VHL ligand 6	Others	Others
	VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound.
T19039	NIR-Thiol dinitrobenzenesulfonate	Others	Others
	NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.
T18842	Thiol-PEG6-acid	Others	Others
	Thiol-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15938	m-PEG8-thiol	Others	Others
	m-PEG8-thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18843	Thiol-PEG8-alcohol HS-PEG8-OH	Others	Others
	Thiol-PEG8-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18840	Thiol-PEG5-acid HS-PEG5-CH2CH2COOH	Others	Others
	Thiol-PEG5-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18844	Thiol-PEG9-alcohol HS-PEG9-OH	Others	Others
	Thiol-PEG9-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18839	Thiol-PEG4-alcohol HS-PEG4-OH	Others	Others
	Thiol-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18841	Thiol-PEG5-alcohol HS-PEG5-OH	Others	Others
	Thiol-PEG5-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17074	Thiol-PEG3-acid	Others	Others
	Thiol-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17080	Thiol-PEG8-acid	Others	Others
	Thiol-PEG8-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17079	Thiol-PEG6-alcohol HS-PEG6-OH	Others	Others
	Thiol-PEG6-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17076	Thiol-PEG3-phosphonic acid	Others	Others
	Thiol-PEG3-phosphonic acid is a PEG-based linker compound utilized in PROTAC synthesis[1].
T18837	Thiol-PEG12-alcohol HS-PEG12-OH	Others	Others
	Thiol-PEG12-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18835	Thiol-PEG10-alcohol HS-PEG10-OH	Others	Others
	Thiol-PEG10-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14716	Boc-Aminooxy-PEG3-thiol	Others	Others
	Boc-Aminooxy-PEG3-thiol is a polyethylene glycol (PEG)-based PROTAC linker, employed for the synthesis of PROTACs[1].
T18832	Thiol-PEG-CH2COOH (MW 2000)	Others	Others
	Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].
T18833	Thiol-PEG-CH2COOH (MW 3400)	Others	Others
	Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative employed as a PROTAC linker for PROTAC synthesis[1].
T18834	Thiol-PEG-CH2COOH (MW 5000)	Others	Others
	Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1].
T17399	Amine-PEG-thiol (MW 3400)	Others	Others
	Amine-PEG-thiol (MW 3400) is a polyethylene glycol (PEG)-based linker molecule containing an amine group and a thiol group. It serves as an essential component in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T18110	m-PEG-thiol (MW 20000)	Others	Others
	m-PEG-thiol (MW 20000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17400	Amine-PEG-thiol (MW 5000)	Others	Others
	Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG) based PROTAC linker, primarily utilized for the synthesis of PROTACs[1].
T17398	Amine-PEG-thiol (MW 2000)	Others	Others
	Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker employed in PROTAC synthesis[1].
T18602	VH032-thiol-C6-NH2 VHL Ligand-Linker Conjugates 14,E3 ligase Ligand-Linker Conjugates 29	Others	Others
	VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.
T18109	m-PEG-thiol (MW 2000)	Others	Others
	m-PEG-thiol (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18108	m-PEG-thiol (MW 10000)	Others	Others
	m-PEG-thiol (MW 10000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18111	m-PEG-thiol (MW 5000)	Others	Others
	m-PEG-thiol (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

化合物

Cysteine thiol probe

Cat.No: T8483

Synonym: Methyl (4-bromobenzoyl)-L-cysteinate

Target: Others

Amifostine thiol dihydrochloride

Cat.No: TQ0133

Synonym: WR 1065,硫代乙基氨基乙基胺盐酸盐

Target: p53

Cat.No: T40746

Synonym: m-PEG7-thiol

Thiol-C9-PEG4

Cat.No: T38701

Synonym: Thiol-C9-PEG4

Thiol-C9-PEG7

Cat.No: T38703

Synonym: Thiol-C9-PEG7

Thiol-C9-PEG5

Cat.No: T38702

Synonym: Thiol-C9-PEG5

Thiol-C10-amide-PEG8

Cat.No: T38756

Synonym: Thiol-C10-amide-PEG8

Thiol-C9-PEG4-acid

Cat.No: T40824

Synonym: Thiol-C9-PEG4-acid

Aminooxy-PEG3-C2-thiol

Cat.No: T23728

Synonym: Aminooxy-PEG3-thiol HCl,Aminooxy-PEG3-thiol HCl salt

Thiol-PEG2-t-butyl ester

Cat.No: T38821

Synonym: Thiol-PEG2-t-butyl ester

Thiol-PEG4-Boc

Cat.No: T17078

Synonym: Thiol-PEG4-t-butyl ester

Target: Others

Thiol-PEG3-Boc

Cat.No: T17075

Synonym: Thiol-PEG3-t-butyl ester

Target: Others

Thiol-PEG3-NHBoc

Cat.No: T34789

Synonym: t-Boc-N-amido-PEG3-thiol

Amifostine thiol

Cat.No: T37538

Thiol-C2-PEG2-OH

Cat.No: T20973

Synonym: Thiol-PEG3-alcohol,HS-PEG3-OH

Cat.No: T18184

Synonym: M-PEG3-Thiol,2-(2-(2-Methoxyethoxy)Ethoxy)Ethanethiol

Target: Others, PROTAC Linker

Cat.No: T12776L

Target: Others

Propargyl-PEG4-thiol

Cat.No: T16634

Target: Others

Thiol-PEG12-acid

Cat.No: T18836

Target: Others

Bis-PEG5-thiol

Cat.No: T30477

m-PEG12-Thiol

Cat.No: T18144

Target: Others

Thiol-PEG4-acid

Cat.No: T17077

Target: Others

Cat.No: T15917

Target: Others

Cat.No: T18600

Synonym: VHL ligand 6

Target: Others

NIR-Thiol dinitrobenzenesulfonate

Cat.No: T19039

Target: Others

Thiol-PEG6-acid

Cat.No: T18842

Target: Others

Cat.No: T15938

Target: Others

Thiol-PEG8-alcohol

Cat.No: T18843

Synonym: HS-PEG8-OH

Target: Others

Thiol-PEG5-acid

Cat.No: T18840

Synonym: HS-PEG5-CH2CH2COOH

Target: Others

Thiol-PEG9-alcohol

Cat.No: T18844

Synonym: HS-PEG9-OH

Target: Others

Thiol-PEG4-alcohol

Cat.No: T18839

Synonym: HS-PEG4-OH

Target: Others

Thiol-PEG5-alcohol

Cat.No: T18841

Synonym: HS-PEG5-OH

Target: Others

Thiol-PEG3-acid

Cat.No: T17074

Target: Others

Thiol-PEG8-acid

Cat.No: T17080

Target: Others

Thiol-PEG6-alcohol

Cat.No: T17079

Synonym: HS-PEG6-OH

Target: Others

Thiol-PEG3-phosphonic acid

Cat.No: T17076

Target: Others

Thiol-PEG12-alcohol

Cat.No: T18837

Synonym: HS-PEG12-OH

Target: Others

Thiol-PEG10-alcohol

Cat.No: T18835

Synonym: HS-PEG10-OH

Target: Others

Boc-Aminooxy-PEG3-thiol

Cat.No: T14716

Target: Others

Thiol-PEG-CH2COOH (MW 2000)

Cat.No: T18832

Target: Others

Thiol-PEG-CH2COOH (MW 3400)

Cat.No: T18833

Target: Others

Thiol-PEG-CH2COOH (MW 5000)

Cat.No: T18834

Target: Others

Amine-PEG-thiol (MW 3400)

Cat.No: T17399

Target: Others

m-PEG-thiol (MW 20000)

Cat.No: T18110

Target: Others

Amine-PEG-thiol (MW 5000)

Cat.No: T17400

Target: Others

Amine-PEG-thiol (MW 2000)

Cat.No: T17398

Target: Others

VH032-thiol-C6-NH2

Cat.No: T18602

Synonym: VHL Ligand-Linker Conjugates 14,E3 ligase Ligand-Linker Conjugates 29

Target: Others

m-PEG-thiol (MW 2000)

Cat.No: T18109

Target: Others

m-PEG-thiol (MW 10000)

Cat.No: T18108

Target: Others

m-PEG-thiol (MW 5000)

Cat.No: T18111

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5968	DL-Homocysteine thiolactone hydrochloride DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐	Endogenous Metabolite	Metabolism
	DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。
T67708	Thiolutin Acetopyrrothin	Antibacterial; Antibiotic	Microbiology/Virology
	Thiolutin (Acetopyrrothin) 是一种内皮细胞粘附抑制剂，由链霉菌产生。 Thiolutin 具有抗生素和抗血管生成特性。 Thiolutin 可快速诱导 Hsp27 的磷酸化。
T1080	2-Aminoethanethiol 2-Mercaptoethylamine,巯基乙胺,β-Mercaptoethylamine,β-MEA,Cysteamine	Apoptosis; Others; Reactive Oxygen Species; Cysteine Protease; Somatostatin; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB; Others; Proteases/Proteasome
	2-Aminoethanethiol (Cysteamine) 是一种胱氨酸消耗剂。半胱胺的作用机制是胱氨酸二硫化物还原。
T2S0633	Raspberry ketone Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮	PPAR	DNA Damage/DNA Repair; Metabolism
	Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物，主要用作化妆品的香料和食品增味剂，也可作 PPAR-α激动剂。
T2O2733	L-Cystine Cystine Acid,cystine,胱氨酸,L-胱氨酸	Antioxidant; Ferroptosis; Endogenous Metabolite	Apoptosis; Metabolism; oxidation-reduction
	L-Cystine (Cystine Acid) 是一种从半胱氨酸氨基酸硫醇侧链氧化获得的含硫衍生物。它起到抗氧化剂的作用，保护组织免受辐射和污染，减缓衰老过程。它还有助于蛋白质合成。
T21033	Adenanthin Adenanthin A,Adenanthin-A,AdenanthinA
	Adenanthin, a natural inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.

天然产物

DL-Homocysteine thiolactone hydrochloride

Cat.No: T5968

Synonym: DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐

Target: Endogenous Metabolite

Cat.No: T67708

Synonym: Acetopyrrothin

Target: Antibacterial, Antibiotic

2-Aminoethanethiol

Cat.No: T1080

Synonym: 2-Mercaptoethylamine,巯基乙胺,β-Mercaptoethylamine,β-MEA,Cysteamine

Target: Apoptosis, Others, Reactive Oxygen Species, Cysteine Protease, Somatostatin, Endogenous Metabolite, Autophagy

Raspberry ketone

Cat.No: T2S0633

Synonym: Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮

Target: PPAR

Cat.No: T2O2733

Synonym: Cystine Acid,cystine,胱氨酸,L-胱氨酸

Target: Antioxidant, Ferroptosis, Endogenous Metabolite

Cat.No: T21033

Synonym: Adenanthin A,Adenanthin-A,AdenanthinA

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