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NIR-Thiol dinitrobenzenesulfonate

产品编号 T19039 CAS T19039

NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.

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NIR-Thiol dinitrobenzenesulfonate Chemical Structure

NIR-Thiol dinitrobenzenesulfonate, CAS T19039

规格	价格/CNY		货期	数量
100 mg	待询		待询
500 mg	待询		待询

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.
体外活性	NIR-Thiol dinitrobenzenesulfonate is highly selective to typical small molecular weight biological thiols (Cys, Hcy, and GSH) over other biorelevant species, such as Phe, Gly, Arg, Lys, Tyr, Leu, glucose, Ser, and Val. The sensor NIR-Thiol dinitrobenzenesulfonate is incubated with living HeLa or Bel 7702 cells, and bright fluorescence is observed. NIR-Thiol dinitrobenzenesulfonate has some prominent features, including NIR absorption and emission, rapid response, high sensitivity, excellent selectivity, good cell membrane permeability, and low cytotoxicity.
体内活性	A different amount (0, 20, 40, or 160 nmol) of NIR-Thiol dinitrobenzenesulfonate is injected into the i.p cavity of mice. Strong fluorescence is noted for the mice injected with 20 nmol of NIR-Thiol dinitrobenzenesulfonate, whereas almost no fluorescence is observed in the control mice. In addition, the mice injected with a higher amount (40 or 160 nmol) of NIR-Thiol dinitrobenzenesulfonate provides brighter fluorescence. A very large signal-to-noise contrast ratio (ca. 700-fold enhancement) is observed for the mice injected with 20 nmol of NIR-Thiol dinitrobenzenesulfonate. In addition, the signal-to-noise contrast ratio jumped to ca. 2900- or 7400-fold enhancement when the mice are injected with 40 or 160 nmol of NIR-Thiol dinitrobenzenesulfonate, respectively.

分子量	875.83
分子式	C39H33N5O15S2
CAS No.	T19039

存储

keep away from direct sunlight　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Yuan L, et al. A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J Am Chem Soc. 2012 Aug 15;134(32):13510-23.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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