39
6
Cat. No. | Product Name | Target | Signaling Pathways |
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T0287 |
Hexamethonium Bromide
Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide |
Apoptosis; Dopamine Receptor; AChR | Apoptosis; GPCR/G Protein; Neuroscience |
Hexamethonium Bromide (Hexamethonium Dibromide) 是神经节中神经元型烟碱型 AChR 的特异性拮抗剂。在自发性高血压动物模型中,它能降低其交感神经活动和血压。 | |||
T28540 |
Ripisartan
UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6 |
RAAS | Endocrinology/Hormones |
Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂,对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。 | |||
T12160 |
N6-Cyclohexyladenosine
CHA,A1受体促进剂 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
N6-Cyclohexyladenosine (CHA) 是一种选择性腺苷 A1 受体激动剂,EC50 为 8.2 nM。 | |||
T68095 |
Losulazine
|
Dopamine Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Losulazine 是一种新型的降压化合物。其确切的作用机制尚未确定,但其降压作用取决于完整的、功能性交感神经系统的存在。 | |||
T5954 |
Methyldopa hydrate
L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate |
Dopamine Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methyldopa hydrate (MK-351 hydrate) 是一种前药,在中枢神经系统中被代谢成 α-Methylepinephrine。它是一种 α-肾上腺素能激动剂,对α2-adrenergic receptors 有选择性。 | |||
TP1618L |
PACAP-38 (31-38), human, mouse, rat acetate
PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base) |
PACAP | GPCR/G Protein |
PACAP-38 (31-38), human, mouse, rat acetate 是 PAC1 受体的激活剂。PACAP-38 (31-38), human, mouse, rat acetate 对交感神经元 NPY 和儿茶酚胺的产生具有强效、有效和持续的刺激作用,可用于神经营养和神经保护研究。 | |||
T22963 |
McN-A 343
|
AChR | Neuroscience |
McN-A 343作为选择性M1 muscarinic激动剂, 以其刺激交感神经节中muscarinic传导的能力而闻名。在溃疡性结肠炎的实验模型中,它已被发现能有效减轻炎症和氧化应激。 | |||
T20344 |
Acetylcholine bromide
|
Others | Others |
Acetylcholine bromide 是乙酰胆碱的溴化物盐。它是一种神经递质,存在于神经肌肉接头、自主神经节、副交感神经效应器接头、交感神经效应器接头的一个子集以及中枢神经系统的许多部位。 | |||
T29548 |
Acetabuton
Aceperone |
||
Acetabuton is an alpha-adrenergic blocker and a hemodynamic and sympathetic drug. | |||
T68634 | Wy 26392 | ||
Wy 26392 is an alpha 2 adrenoceptors antagonist that increase central sympathetic tone and blood pressure in low doses. | |||
T24603 |
PD-34799-SA
PD 34799-SA,PD34799-SA |
||
PD-34799-SA is an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation. | |||
T68397 | Xamoterol fumarate | ||
Xamoterol fumarate is a selective beta-1-adrenergic partial agonist. Because it is a partial agonist, it acts as an agonist when sympathetic activity is low and as an antagonist when sympathetic activity is high. It reduces myocardial ischemia and improves ventricular function in patients with mild to moderate heart failure. In patients with severe heart failure it has been shown to produce benefits in systolic and diastolic function. | |||
T68190 | Carmoxirole (free base) | ||
Carmoxirole (free base) is a dopamine D2 receptor agonist with limited central activity that modulates sympathetic activation and subsequently reduces pre-load and afterload in animals. It was shown, that carmoxirole induced beneficial effects on hemodynamic and neurohumoral parameters in heart failure. In addition, experimental evidence showed that carmoxirole lowered blood pressure in various models of hypertension mainly or exclusively through inhibition of noradrenaline release from sympathe... | |||
TP1618 |
PACAP-38 (31-38), human, mouse, rat
|
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PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. | |||
TP1414 |
PACAP-38 (31-38), human, mouse, rat TFA
|
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PACAP-38 (31-38), human, mouse, rat (TFA) demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal. | |||
T9097L |
Guanadrel Sulfate
CL 1388R,U 28288D,CHEBI:5556,Hylorel,Hyloride |
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Guanadrel Sulfate is a postganglionic adrenergic blocking agent. The uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. | |||
T70269 | Hexamethonium chloride dihydrate | ||
Hexamethonium chloride dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant. | |||
TP1619 |
PACAP-38 (16-38), human, mouse, rat
|
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PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. | |||
T24032 |
Ephedrine levulinate
L-Ephedrine levulinate |
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Ephedrine levulinate is an alkaloid. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. | |||
T68714 | Iobenguane I 131 | ||
Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase. | |||
TP1490 |
Proadrenomedullin (1-20), human
|
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Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena | |||
T69161 | Hexamethonium bromide dihydrate | ||
Hexamethonium bromide dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant. | |||
T68645 |
Hexamethonium monotartrate
|
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Hexamethonium monotartrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant. | |||
TP1609 |
Angiotensin II (1-4), human
|
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Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers. | |||
T15455 |
RGH-5526
GYKI-11679 |
Others | Others |
RGH-5526是一种新型的抗高血压药。它引起下丘脑去甲肾上腺素(NA)周转(利用)增加,下丘脑去甲肾上腺素能神经元活性的增加可能导致外周交感神经活性的降低,从而显著降低血压。 | |||
T68807 |
Azelnidipine, (R)-
|
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Azelnidipine, (R)-, is an L-type calcium channel blocker (CCB). Studies have shown that in patients with hypertension (HT) and heart failure preserved ejection fraction (HFpEF), azelnidipine improved the severity of HF and cardiac sympathetic nerve activity compared with cilnidipine, an N-type CCB (Cat#326734). | |||
TP1144 |
Corticotropin-releasing factor (human)
Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human |
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Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b | |||
T50109 |
Guanethidine
|
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Guanethidine 于1959年合成,被认为可以通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。 | |||
T37373 |
4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
|
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4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity. | |||
T68806 |
Azelnidipine, (S)-
|
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Azelnidipine, (S)-, is an L-type calcium channel blocker (CCB). Studies have shown that in patients with hypertension (HT) and heart failure preserved ejection fraction (HFpEF), azelnidipine improved the severity of HF and cardiac sympathetic nerve activity compared with cilnidipine, an N-type CCB (Cat#326734). | |||
T25912 |
Oxypyrronium bromide
L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055 |
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Oxypyrronium bromide 一种含有季铵的抗胆碱能和解痉剂。在动物模型中,它抑制胃运动、迷走神经刺激或乙酰胆碱静脉注射引起的低血压;鼓索神经刺激引起的流涎和节前颈交感神经刺激引起收缩。 | |||
T68811 | Trimetaphan camsilate | ||
Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously. | |||
T80080 |
PAMP-12 (unmodified) (TFA)
|
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PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂,展现出高效性(EC50=20-50 nM)。该化合物为内源性肽,能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。 | |||
T78027 |
PAMP-12 (unmodified)
|
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PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂,其EC50值为20-50 nM。作为内源性肽,它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。 | |||
T76539 |
Insulin-like growth factor II
|
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Insulin-like growth factor II (IGF-2)为人血清中主要生长激素,对神经突生长具有许可性和直接作用,同时增强交感与感觉神经元的生存能力。 | |||
T60304 | (E)-Guanabenz | ||
(E)-Guanabenz ((E)-Wy-8678) 是一种具有口服活性的中枢α2-肾上腺素受体 (α2-adrenoceptor)激动剂。(E)-Guanabenz 具有抗高血压活性,通过刺激中枢 α2- 肾上腺素受体,并减少交感神经向外周的净流出而起作用。(E)-Guanabenz z 也直接结合并抑制 GADD34,具有神经保护活性。(E)-Guanabenz 可用于研究高血压和帕金森病。 | |||
T20886 |
Atomoxetine
Tomoxetine,HSDB7352,HSDB-7352,HSDB 7352 |
Norepinephrine | Neuroscience |
Atomoxetine (HSDB 7352) 是一种选择性去甲肾上腺素抑制剂,它可能通过增加外周交感神经元中的去甲肾上腺素浓度而导致血压升高 。Atomoxetine 是突触前去 Norepinephrativev 转运体的高度选择性拮抗剂,对其他去甲肾上腺素受体或其他神经递质转运体或受体几乎或没有亲和力,但对5-羟色胺转运体的亲和力较弱。、 Atomoxetine 选择性地抑制去甲肾上腺素的再摄取,可用于治疗患有多动症和慢性抽搐的青少年。 | |||
T74142 |
Angiotensin II human TFA
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Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽,扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应,包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外,Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成,导致血管壁与心肌增厚及纤维化,并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。 | |||
T36729 |
Urotensin II (goby) (trifluoroacetate salt)
|
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Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6751 |
Acetylcholine iodide
Acetylcolina |
Others | Others |
Acetylcholine iodide (Acetylcolina) 是一种在中枢和外周神经系统中常见的神经递质。 | |||
T1287 |
Synephrine
辛弗林,Oxedrine |
Endogenous Metabolite; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂,是一种生物碱。它也是一种拟交感神经化合物,能够用于减肥。 | |||
T7040 |
Angiotensin II human
DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Angiotensin II human (Ang II) 是一种生物活性肽,一种血管收缩剂。Angiotensin II 可以与 AT1R 和 AT2R 相互作用,调节人类血压,刺激交感神经,增加醛固酮生物合成和肾脏活动。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
T2S1727 |
Lycorenine
|
Antifection | Microbiology/Virology |
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph | |||
T20173 |
Noradrenaline tartrate
NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate |
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Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. |