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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2301	SB 202190 FHPI,SB202190	Apoptosis; p38 MAPK; Autophagy	Apoptosis; Autophagy; MAPK
	SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂，可以抑制 p38α 和 p38β2 (IC50=50/100 nM)，具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性，还可以诱导人胚胎干细胞向心肌细胞分化。
T21793	CGP 35348	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T1418	Bucladesine sodium dbcAMP,Dibutyryl-cAMP sodium salt,布拉地新钠盐,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt	PKA; PDE	Metabolism; Tyrosine Kinase/Adaptors
	Bucladesine sodium (DC2797) 是一种 cAMP 类似物，具有细胞渗透性。Bucladesine sodium 也是一种 cAMP 依赖性的蛋白激酶 (PKA) 激活剂，一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium 具有抗炎活性。
T72079	Biotin-aniline
	Biotin-aniline 是一种会对 RNA 和 DNA做出强烈反应的探针。Biotin-aniline 具有高效性，用于捕获具有高空间特异性的活细胞中的亚细胞转录组。
TP1924L1	ZIP acetate(863987-12-6 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	ZIP acetate(863987-12-6 free base) 是一种新型的细胞渗透性蛋白激酶 Mζ (PKMζ) 抑制剂，它是一种参与 LTP 维持的组成型活性非典型 PKC 同工酶。在体外选择性阻断 PKMζ 诱导的海马切片突触增强。逆转晚期 LTP (IC50 = 1 - 2.5 μM) 并在体内中央给药后导致 1 天前的空间记忆持续丧失。
T18989	Fluo-3AM Fluo-3-pentaacetoxymethyl ester	Others	Others
	Fluo-3AM is a calcium indicator that exhibits an increase in fluorescence upon binding Ca2+. It is used to image the spatial dynamics of Ca2+ signaling in flow cytometry experiments.
T40833	ω-Hydroxy-DEET
	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
TP2135	cAC 253
	Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
T70581	CY208-243 Mandelate
	CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY208,243 was superior in improving the strength of neuronal outcome sensitivity to the working memory-related choice behavior in the T-maze.
T35546	Yhhu 3792
	Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.
T70595	Artemisinin B
	Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases.
T79484	Nrf2 activator-8
	Nrf2 activator-8（化合物 10e）作为一种效能显著的Nrf2激活剂（EC50=37.9 nM），在BV-2微神经胶质细胞中展现出优异的抗氧化及抗炎效应。此外，Nrf2 activator-8可有效逆转脂多糖（LPS）诱导的小鼠神经炎症模型中的空间记忆缺失。
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
T36781	st-Ht31 P st-Ht31 P
	Negative control for st-Ht31 . Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID:28192412 \|Vijayaraghavan et al (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J.Biol.Chem. 272 4747 PMID:9030527 \|Vincent et al (2017) Signaling: Spatial regulation of axonal cAMP. Nat.Chem.Biol. 13 348 PMID:28328917
TP1924	ZIP
	Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1
T79569	AChE/Aβ-IN-1
	AChE/Aβ-IN-1（compound 32）是一种双功能化合物，既表现出高效的AChE抑制活性，IC50值为86 nM，又能作为NMDA受体(GluN1-1b/GluN2B亚基组合)的拮抗剂，其IC50为3.876 μM。此外，它能够抑制Aβ聚集，且表现出优秀的血脑屏障穿透能力和神经保护效果，能在大鼠模型中显著改善认知和空间记忆障碍。
T61930	Yhhu-3792
	Yhhu-3792 激活 Notch 信号通路并促进 Hes3 和 Hes5 的表达。Yhhu-3792 增强神经干细胞 (NSC) 的自我更新能力，扩大了 NSC 池并促进了小鼠海马齿状回部分 (DG) 的内源性神经形成。Yhhu-3792 可提高小鼠的情景和空间记忆能力。 Yhhu-3792 在记忆障碍相关 DG 功能障碍中具有研究潜力。
T79571	AChE/Aβ-IN-2
	AChE/Aβ-IN-2（compound 32）是一种双重功能性化合物，作为乙酰胆碱酯酶（AChE）的有效口服抑制剂，表现出86 nM的IC50，同时也对NMDA受体（GluN1-1b/GluN2B亚基组合）起拮抗作用，其IC50为3.876 μM。该化合物能够抑制Aβ聚集，具有良好的血脑屏障渗透性，并表现出神经保护效果。在大鼠模型中，AChE/Aβ-IN-2展现出改善认知和空间记忆障碍的潜力。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...
T64672	Colivelin TFA
	Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activator of STAT3. Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. Co...
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Cat.No: T2301

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

Cat.No: T21793

Target: GABA Receptor

Bucladesine sodium

Cat.No: T1418

Synonym: dbcAMP,Dibutyryl-cAMP sodium salt,布拉地新钠盐,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt

Target: PKA, PDE

Cat.No: T72079

ZIP acetate(863987-12-6 free base)

Cat.No: TP1924L1

Target: PKC

Cat.No: T18989

Synonym: Fluo-3-pentaacetoxymethyl ester

Target: Others

ω-Hydroxy-DEET

Cat.No: T40833

Cat.No: TP2135

CY208-243 Mandelate

Cat.No: T70581

Cat.No: T35546

Cat.No: T70595

Nrf2 activator-8

Cat.No: T79484

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

Cat.No: T36781

Synonym: st-Ht31 P

Cat.No: TP1924

Cat.No: T79569

Cat.No: T61930

Cat.No: T79571

Cat.No: TP2182

Target: Others

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Cat.No: T64672

para-amino-Blebbistatin

Cat.No: T36400

Cat. No.	Product Name	Target	Signaling Pathways
T2777	Ginsenoside Rg1 Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2	Apoptosis; Beta Amyloid; NF-κB	Apoptosis; Neuroscience; NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。

天然产物

Ginsenoside Rg1

Cat.No: T2777

Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2

Target: Apoptosis, Beta Amyloid, NF-κB

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