Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11857 |
LIT-001
|
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
LIT-001 是非肽类催产素受体激动剂,EC50为55 nM,Ki 为226 nM。它可改善孤独症小鼠模型的社交互动。 | |||
T9317 |
TAK-041
NBI-1065846 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
TAK-041 (NBI-1065846) 是一种选择性 GPR139激动剂,EC50为 22 nM,有用于精神分裂症阴性症状的研究潜力。 | |||
T1180 |
Blonanserin
布南色林,AD-5423 |
Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂,Ki 为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。 | |||
T15022 |
CVT-10216
3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸 |
Dehydrogenase | Metabolism |
CVT-10216 是可逆的、选择性的醛脱氢酶 2(ALDH-2)抑制剂,IC50为 29 nM。对 ALDH-1的抑制作用较弱,IC50为 1.3 μM。 它可以减少偏爱酒精的大鼠过量饮酒,并表现出抗焦虑作用。 | |||
T23483 |
U 99194 maleate
U-99194A maleate,U-99194 maleate salt,U-99194 maleate |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
U 99194 maleate (U-99194A maleate) 是一种 D3 拮抗剂,可增加隔离诱导的攻击性雄性小鼠的社会行为。 | |||
T23444 |
TCS 1105
N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide |
Others | Others |
TCS 1105是一种GABAA 苯并二氮卓受体(BZR)配体。TCS 1105阻断Sema3A 诱导的轴突生长锥塌陷。TCS 1105能减少小鼠的焦虑样行为,增强攻击性行为和社会支配力。 | |||
T22453 |
Venlafaxine
Wy 45030,文拉法辛 |
Serotonin Transporter | Neuroscience |
Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂,具有抗抑郁活性。 | |||
T25672 |
Lesopitron
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lesopitron 是一种具有突触前和突触后5-HT1A 激动剂活性的抗焦虑剂,在大鼠社会交往和狨猴焦虑模型中比5-HT1A 激动剂更有效。Lesopitron 能对抗苯二氮卓类药物戒断引起的啮齿动物的焦虑且急性毒性很低,不会增强酒精或巴比妥类药物的作用。 | |||
T32191 |
Irdabisant
CEP-26401,CEP 26401,CEP26401 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中,Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。 | |||
T37816 |
SB 243213
|
||
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. SB 243213 shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows... | |||
T76183 |
Corazonin
|
||
Corazonin是一种在昆虫体内普遍存在的高度保守神经肽激素,主要调节社会性昆虫的等级身份和行为。它在工蜂和/或其他社会性昆虫的觅食个体中优先表达。 | |||
T11856 |
LIT-001 free base
|
Others | Others |
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). | |||
T68683 | Sertraline Free Base | ||
Sertraline Free Base is a Selective Serotonin Reuptake Inhibitor (SSRI). It can treat depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorder, and panic disorder. | |||
T38192 |
Unifiram
|
Others | Others |
Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。 | |||
T37920 |
7(Z),11(Z)-Heptacosadiene
|
||
The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner. | |||
T40528 |
Oxytocin free acid
9-Deamidooxytocin |
||
Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. Oxytocin, a pleiotropic peptide hormone, has wide-ranging implications for general health, adaptation, development, reproduction, and social behavior. | |||
T82266 |
GPR139 agonist-2
|
||
GPR139agonist-2 (compound 20a) 是高效GPR139激动剂,具EC50值为24.7 nM。此化合物能改善小鼠精神分裂症模型社交互动缺失,同时缓解认知障碍,显示出其作为抗精神分裂症研究药物的潜在价值。 | |||
TP1504 |
Urocortin III, mouse TFA (357952-10-4 free base)
Urocortin III, mouse TFA |
||
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th | |||
T76025 |
Urocortin III, mouse TFA
|
||
Urocortin III, mouse TFA是CRF(促肾上腺皮质激素释放因子)相关的肽。该化合物主要通过结合并激活CRF-R2发挥作用。Urocortin III(Ucn3)是已知参与调节行为压力反应体系的组分之一。它和CRF-R2在大脑杏仁核中共同作用,从而参与调控复杂的社会动力学行为。 | |||
T37114 |
SB 242084 dihydrochloride
|
||
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... | |||
T61197 |
Irdabisant hydrochloride
|
||
Irdabisant (CEP-26401) hydrochloride 是一种选择性、口服活性的组胺H3受体拮抗剂/逆激动剂,具备良好的血脑屏障渗透性。该化合物对大鼠和人类的H3受体具有高亲和力,其Ki值分别为7.2 nM和2.0 nM。此外,Irdabisant hydrochloride在抑制hERG电流方面表现出较低的活性,IC50为13.8 μM。在大鼠社会认知模型中,它展现了认知增强和唤醒的效果,可作为精神分裂症或认知障碍研究的潜在工具。 | |||
T83665 |
α-Helical CRF (9-41) TFA
α-Helical Corticotropin-Releasing Factor (9-41) |
||
α-Helical CRF (9-41) 是一种合成的皮质酮释放因子(CRF)拮抗剂。它在0.5至5 µM浓度范围内,能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素(ACTH)。在体内研究中,α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放,并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外,α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间,并减少小鼠的类似暴饮暴食的乙醇消费。 | |||
T83825 |
Trofinetide acetate
NNZ-2566 |
||
Trofinetide是一种衍生自具有神经保护作用的三肽Gly-Pro-Glu的化合物,后者是胰岛素样生长因子-1(IGF-1)的N-端序列。在10 nM的浓度下使用时,它能减少由蛋白磷酸酶抑制剂奥卡达酸在原代大鼠胚胎纹状体神经元中引起的细胞死亡。Trofinetide在一种由穿透性弹道样脑损伤引起的大鼠神经炎症模型中减少了编码IL-1β、TNF-α、IL-6和E-selectin的mRNA的脑表达。在通过中脑动脉闭塞(MCAO)引起的大鼠脑损伤模型中,以30和60 mg/kg的剂量给药时,它减少了皮层和纹状体梗塞区域。Trofinetide(每天100 mg/kg)减少了树突棘的数量,并逆转了在fmr1-/-敲除小鼠脆性X综合征模型中的社交识别和情景恐惧条件反射的缺陷,同时也减少了睾丸重量的增加。含有Trofinetide的制剂已被用于治疗Rett综合征。 | |||
T37837 |
2-Methylhexacosane
|
||
2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone.1,2It has been found in the cuticle ofM. dasystomusfemales, but not males, where it contributes to the mating behavior of males, as well as inD. melanogasterfemales where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.3 1.Spikes, A.E., Pashen, M.A., Millar, J.G., et al.First contact pheromone identified for a longhorned beetle (Coleoptera: ... |