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Cat. No. Product Name Target Signaling Pathways
T3508 SEA0400

SEA 0400,2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA-0400

 Calcium Channel; Na+/Ca2+ Exchanger Membrane transporter/Ion channel; Metabolism
SEA0400 是 Na+/Ca2+ 交换剂的选择性抑制剂，在培养的神经元、星形胶质细胞和小胶质细胞中，能够抑制 Na+-依赖性 Ca2+的吸收，IC50值为 5-33 nM。
T78312 Cifurtilimab

SEA-CD40
Cifurtilimab（SEA-CD40）是一种具有抗癌活性的人源化抗CD40 IgG1单克隆抗体。
T20812 Azamethiphos

甲基吡啶磷,唑啶磷

 AChE Neuroscience
Azamethiphos 是有机磷杀虫剂和神经毒性物质，能够抑制乙酰胆碱酯酶的活性。
T69110 Aseanostatin P5

Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T80341 Seabream hepcidin

Seabream hepcidin是一种抗菌肽，具有针对细菌(V.anguillarum)、真菌(S.cerevisiae)以及病毒性出血性败血症病毒的活性。
T19437 MTSEA hydrobromide

Others Others
MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain similar in size to lysine.
T75368 MTSEA-Fluorescein

MTSEA-Fluorescein 是一种可用于离子通道研究的荧光探针。储存方式：避光。
T76252L WLSEAGPVVTVRALRGTGSW TFA

WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体，提高心肌细胞的特定摄取能力，降低心肌细胞凋亡率，并在体内心肌内注射后提升心脏潴留能力。
T77841 Duostatin 5

Others Others
Duostatin 5 (Duo-5)是一种海兔毒素类似物，常用于合成 ADC 化合物。
T7487L Speract TFA(76901-59-2(free base))

Others Others
Speract TFA(76901-59-2(free base)) 是一种海胆卵肽，可调节精子活力，也可刺激精子线粒体代谢。
TP1699L SEB Domain 144-153 acetate(210229-94-0 free base)

Others Others
SEB Domain 144-153 acetate(210229-94-0 free base) 是葡萄球菌肠毒素 B 结构域氨基酸残基 163-172。它已被证明可抑制多种葡萄球菌肠毒素、SEA、SEE 和 TSST-1 的转胞吞作用。
T65687 CAPS

N-Cyclohexyl-3-aminopropanesulfonic acid

 Others Others
CAPS (N-Cyclohexyl-3-aminopropanesulfonic acid) 是一种表面活性剂，可作为化学发光增强剂，可用于开发深海原位分析仪。
T34298 Retene

NSC 26317,NSC-26317,NSC26317
Retene (NSC-26317) 广泛存在于近代和古代沉积物中，可从冷杉林土壤、腐殖质煤、陆相石油烃源岩和深海沉积物中提取得到化合物。Retene 是松木酸在成岩作用过程中脱氢产生的。
T30099 Aplysistatin

Aplysistatin is a bromosesquiterpene derived from sea mollusks.
T32595 Laurencin

NSC 122763,NSC122763,NSC-122763
Laurencin is a component of the sea hare, Aplysia dactylomela.
TP2426 Cucumarioside C2

Cucumarioside C2 is a sea cucumber glycoside.
T31186 Dactylomelol

Dactylomelol is a new type of diterpene from sea hare.
T32594 Laureatin

Laureatin is a component of the sea hare, Aplysia dactylomela.
T33860 Pacifenol

Pacifenol is a sesquiterpene isolated from sea weeds and marine alga Laurencia claviformis.
T33884 Parkeol

Parkeol is the triterpene precursor of saponins in sea cucmbers.
T23959 Dactylyne

Dactylyne is a new drug metabolism inhibitor of marine origin. It was isolated from the sea hare Aplysia dactylomela and characterized pharmacologically.
T34058 Phyllospadine

Phyllospadine is a natural flavonoidal alkaloid from the sea-grass Phyllosphadix iwatensis.
T25091 Antho-riamide II

Tyr-arg-ile-NH2,Tyrosyl-arginyl-isoleucinamide
Antho-riamide II is an inactive peptide isolated from sea anemone Anthopleura elegantissima.
T25092 Antho-rpamide II

Glu-asn-phe-his-leu-arg-pro-NH2
Antho-rpamide II is a biologically active neuropeptide isolated from the sea anemone Anthopleura elegantissima.
TP2442 Stichloroside C2

Stichloroside C2 is a triterpene saponin from the sea cucumber Stichopus chloronotus.
T34289 Resact

Resact is an extracellular peptide from egg jelly of the sea urchin Arbacia punctulata.
T32094 Holothurin B

Holothurin B, as a part of a group of toxins, is originally isolated from the sea cucumber Actinopyga agassizi.
T25278 Cucumarioside A2-2

Cucumarioside A2-2 is a triterpene glycoside isolated from the Far-Eastern sea cucumber Cucumaria japonica, that exhibits antitumor activity.
T23739 Antho-riamide I

Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles.
T11325 Frondoside A

Others Others
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T37798 Petromyzonol

Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate ester (petromyzonol sulfate) is a pheromone and a spawning chemoattractant which can be detected at very low concentrations by lamprey olfactory chemoreceptors. Petromyzonol, petromyzonol sulfate, and a...
T25162 Bivittoside A

Bivittoside A 是一种非硫酸化的六苷类化合物，从波氏海参中提取得到，具有抗真菌活性和潜在抗肿瘤活性。
T25163 Bivittoside B

Bivittoside B 是一种非硫酸化的六苷类化合物，从波氏海参中提取得到，具有抗真菌活性和潜在抗肿瘤活性。
TP2163 SEB Domain 144-153 TFA(210229-94-0 free base)

SEB Domain (144-153) (TFA)

 Others Others
SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. It inhibits transcytosis of multiple staphylococcal enterotoxins, SEE, SEA, and TSST-1.
T37489 11(R)-HEPE

11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.
T7487 Speract

精子活化肽

 Others; Mitochondrial Metabolism Metabolism; Others
Speract 是调节精子活力的海胆蛋肽，也能够刺激精子线粒体代谢。
T33538 Mycobactin S

Mycobactin S is made from metabolic products of the acid-resistant form of Mycobacterium phlei, a tuberculosis bacillus derived originally from the cold-blooded sea turtle. Importantly, it is not based on cell wall fragments or killed bacteria.
TP1699 SEB Domain (144-153)

SEB Domain 144-153
SEB Domain (144-153) peptide is Staphylococcal Enterotoxin B domain amino acid residue 163-172. SEB Domain (144-153) has been shown to inhibit transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1.
T37632 TFM

TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formula...
T83121 Anatumomab mafenatox

ABR-214936
Anatumomab mafenatox (ABR-214936)是一种73 KDa的重组蛋白，针对广泛表达于恶性肿瘤中的肿瘤相关抗原5T4。该分子构建于修饰后的SEA和小鼠Fab片段之间。Anatumomab mafenatox的主要副作用包括发烧、低血压、疼痛、恶心和嗜睡。
T37490 11(R)-HETE

11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T37803 8-bromo-Cyclic ADP-Ribose (sodium salt)

Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-...
T80039 ATX-II

Sodium Channel Membrane transporter/Ion channel
ATX-II为特定Na+通道调节剂，源自海葵(Anemonia sulcata)毒液。该化合物会使细胞培养物对Na+Halothane、Caffeine及Ryanodine敏感，并可诱发肺静脉心律失常及心房颤动。
T37263 14-methyl Pentadecanoic Acid methyl ester

14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.
T35777 Nodularin

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff...
T82936 ATX-II TFA

Sodium Channel Membrane transporter/Ion channel
ATX-II TFA为源自海葵(Anemonia sulcata)毒素的特定Na+通道调节剂，能使细胞培养物对Na+、Halothane、Caffeine和Ryanodine敏感，并可诱发肺静脉心律失常和心房颤动。
T38374 2-hydroxy Myristic Acid

2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax. It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively). 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation ...
T75924 APETx2 TFA

APETx2 TFA 是可来自Anthopleura elegantissima 的海葵肽，是选择性的、可逆的酸敏感的离子通道ASIC3 (acid-sensing ion channel)抑制剂，其 IC50值为 63 nM. APETx2 作用在ASIC3 通道外部。APETx2 TFA 能够逆转酸性诱导的炎症疼痛。
T83801 ε-NAADP+ sodium

Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate
ε-NAADP+是钙动员诱导剂NAADP的荧光衍生物。在海胆卵细胞匀浆中诱导钙释放(EC50 = 5 µM)。ε-NAADP+在275 nm和410 nm分别显示激发/发射峰值，且在DMSO中的相对发射增加了三倍。
T35922 NAADP (sodium salt)

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to...

化合物

SEA0400
Cat.No: T3508
Synonym: SEA 0400,2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA-0400
Target: Calcium Channel, Na+/Ca2+ Exchanger
Cifurtilimab
Cat.No: T78312
Synonym: SEA-CD40
Target:
Azamethiphos
Cat.No: T20812
Synonym: 甲基吡啶磷,唑啶磷
Target: AChE
Aseanostatin P5
Cat.No: T69110
Synonym:
Target:
Seabream hepcidin
Cat.No: T80341
Synonym:
Target:
MTSEA hydrobromide
Cat.No: T19437
Synonym:
Target: Others
MTSEA-Fluorescein
Cat.No: T75368
Synonym:
Target:
WLSEAGPVVTVRALRGTGSW TFA
Cat.No: T76252L
Synonym:
Target:
Duostatin 5
Cat.No: T77841
Synonym:
Target: Others
Speract TFA(76901-59-2(free base))
Cat.No: T7487L
Synonym:
Target: Others
SEB Domain 144-153 acetate(210229-94-0 free base)
Cat.No: TP1699L
Synonym:
Target: Others
CAPS
Cat.No: T65687
Synonym: N-Cyclohexyl-3-aminopropanesulfonic acid
Target: Others
Retene
Cat.No: T34298
Synonym: NSC 26317,NSC-26317,NSC26317
Target:
Aplysistatin
Cat.No: T30099
Synonym:
Target:
Laurencin
Cat.No: T32595
Synonym: NSC 122763,NSC122763,NSC-122763
Target:
Cucumarioside C2
Cat.No: TP2426
Synonym:
Target:
Dactylomelol
Cat.No: T31186
Synonym:
Target:
Laureatin
Cat.No: T32594
Synonym:
Target:
Pacifenol
Cat.No: T33860
Synonym:
Target:
Parkeol
Cat.No: T33884
Synonym:
Target:
Dactylyne
Cat.No: T23959
Synonym:
Target:
Phyllospadine
Cat.No: T34058
Synonym:
Target:
Antho-riamide II
Cat.No: T25091
Synonym: Tyr-arg-ile-NH2,Tyrosyl-arginyl-isoleucinamide
Target:
Antho-rpamide II
Cat.No: T25092
Synonym: Glu-asn-phe-his-leu-arg-pro-NH2
Target:
Stichloroside C2
Cat.No: TP2442
Synonym:
Target:
Resact
Cat.No: T34289
Synonym:
Target:
Holothurin B
Cat.No: T32094
Synonym:
Target:
Cucumarioside A2-2
Cat.No: T25278
Synonym:
Target:
Antho-riamide I
Cat.No: T23739
Synonym:
Target:
Frondoside A
Cat.No: T11325
Synonym:
Target: Others
Petromyzonol
Cat.No: T37798
Synonym:
Target:
Bivittoside A
Cat.No: T25162
Synonym:
Target:
Bivittoside B
Cat.No: T25163
Synonym:
Target:
SEB Domain 144-153 TFA(210229-94-0 free base)
Cat.No: TP2163
Synonym: SEB Domain (144-153) (TFA)
Target: Others
11(R)-HEPE
Cat.No: T37489
Synonym:
Target:
Speract
Cat.No: T7487
Synonym: 精子活化肽
Target: Others, Mitochondrial Metabolism
Mycobactin S
Cat.No: T33538
Synonym:
Target:
SEB Domain (144-153)
Cat.No: TP1699
Synonym: SEB Domain 144-153
Target:
TFM
Cat.No: T37632
Synonym:
Target:
Anatumomab mafenatox
Cat.No: T83121
Synonym: ABR-214936
Target:
11(R)-HETE
Cat.No: T37490
Synonym:
Target:
8-bromo-Cyclic ADP-Ribose (sodium salt)
Cat.No: T37803
Synonym:
Target:
ATX-II
Cat.No: T80039
Synonym:
Target: Sodium Channel
14-methyl Pentadecanoic Acid methyl ester
Cat.No: T37263
Synonym:
Target:
Nodularin
Cat.No: T35777
Synonym:
Target:
ATX-II TFA
Cat.No: T82936
Synonym:
Target: Sodium Channel
2-hydroxy Myristic Acid
Cat.No: T38374
Synonym:
Target:
APETx2 TFA
Cat.No: T75924
Synonym:
Target:
ε-NAADP+ sodium
Cat.No: T83801
Synonym: Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate
Target:
NAADP (sodium salt)
Cat.No: T35922
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T8002 3-Hydroxycoumarin

Lipoxygenase Metabolism
3-hydroxycoumarin 是一种 15-LOX-1的有效氧化还原抑制剂，近期被证明能保护海胆生殖细胞免受紫外线 B 的损伤。
TN6388 Methyl epi-dihydrophaseate

Methyl epi-dihydrophaseate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6388，CAS号为 57761-30-5。
T40458 3-Keto petromyzonol

3-Keto petromyzonol, a key constituent of Sea lamprey male sex pheromones, governs the synthesis and release of gonadotropin releasing hormone (GnRH). This in turn regulates the hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey.
T34525 Sarcophine

Sarcophin,Sarcophin A
Sarcophine is a natural cembranoid from the Red Sea soft coral Sarcophyton glaucum.
T80012 Quellenin

Quellenin为一抗水霉化合物，可通过分离深海真菌Aspergillussp.YK-76获得。
T15721 Latrunculin A

LAT-A

 Others Others
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re
T75678 Tomentosin

Apoptosis Apoptosis
Tomentosin 是一种从里海旋覆花中提取出来倍半萜内酯，具有潜在的抗炎和抗癌活性，可促进胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。
T20636 Latrunculin B

LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644

 Antifungal Microbiology/Virology
Latrunculin B 是一种 来自红海海绵的生物碱，是一种肌动蛋白聚合 (actin polymerization) 抑制剂，具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生，可用于研究青少年青光眼。
T37451 Stachybotrysin B

Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen...

天然产物

3-Hydroxycoumarin
Cat.No: T8002
Synonym:
Target: Lipoxygenase
Methyl epi-dihydrophaseate
Cat.No: TN6388
Synonym:
Target:
3-Keto petromyzonol
Cat.No: T40458
Synonym:
Target:
Sarcophine
Cat.No: T34525
Synonym: Sarcophin,Sarcophin A
Target:
Quellenin
Cat.No: T80012
Synonym:
Target:
Latrunculin A
Cat.No: T15721
Synonym: LAT-A
Target: Others
Tomentosin
Cat.No: T75678
Synonym:
Target: Apoptosis
Latrunculin B
Cat.No: T20636
Synonym: LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644
Target: Antifungal
Stachybotrysin B
Cat.No: T37451
Synonym:
Target:
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