36
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21195 |
AICAR monophosphate
Aica ribonucleotide,AICA riboside,Acadesine 5'-monophosphate,Z-nucleotide |
Others | Others |
AICAR monophosphate (Aica ribonucleotide) 是一种具有抗肿瘤活性的嘌呤前体,可用于 2 型糖尿病的研究。 | |||
T9210 |
CD73-IN-4
|
CD73 | Immunology/Inflammation |
CD73-IN-4 是高选择性的亚甲基膦酸 CD73抑制剂,对人 CD73 作用的 IC50值为 2.6 nM,在癌症免疫学中具有研究潜力。 | |||
T0297 |
Clofarabine
Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Clofarabine (Clofarex) 是一种核糖核苷酸还原酶抑制剂,IC50值为65 nM。它是核苷类似物,可用于癌症研究。 | |||
T14864 |
Caracemide
NSC-253272,卡醋胺 |
Others; DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Caracemide (NSC-253272) 抑制大肠杆菌的核糖核苷酸还原酶。 Caracemide 可用于抗癌研究。 | |||
T3157 |
COH29
RNR Inhibitor COH29 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑,是人类核糖核苷酸还原酶 (RNR) 的抑制剂,具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。 | |||
T8855 |
Polydeoxyribonucleotide(Sodium salt)
Polydeoxyribonucleotide from salmon |
Others | Others |
Polydeoxyribonucleotide(Sodium salt) 可改善大鼠跟腱损伤模型中各种生长因子的分泌,促进胶原蛋白合成,恢复跟腱的拉伸强度。 | |||
T0353 |
Osalmid
Oxaphenamide,4'-Hydroxysalicylanilide,羟苯水杨胺,柳胺酚 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Osalmid (Oxaphenamide) 是一种利胆药物,通过靶向核糖核苷酸还原酶小亚基 M2 来抑制核糖核苷酸还原酶的活性,IC50值为8.23 μM。 | |||
T8800 |
NSAH
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂,无细胞 IC50 为 32 μM,基于细胞的 IC50 约为 250 nM。 | |||
T7525 |
Didox
3,4-二羟基苯甲羟肟酸,NSC-324360 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Didox (NSC-324360) 是一种合成的核糖核苷酸还原酶抑制剂,可降低患有痴呆症的 HIV 患者大脑中氧化损伤标志物的水平。 | |||
T1982 |
3-AP
NSC663249,Triapine,PAN-811,OCX191 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3-AP (Triapine) 是一种新型的核糖核苷酸还原酶 M2 亚基抑制剂,也是一种放射致敏剂。 | |||
T31163 |
Cytidine 5'-diphosphate disodium
CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt |
Others | Others |
Cytidine 5'-diphosphate disodium (CDP sodium salt) 产生 CTP 以支持 DNA 和 RNA 生物合成和核糖核苷酸还原酶以产生 dCMP。 | |||
T15826 |
Lometrexol
LY 264618,DDATHF |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Lometrexol (LY 264618) 是一种抗嘌呤类抗叶酸 (Antifolate) 药,可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性,但不会引起可检测水平的 DNA 链断裂。Lometrexol 可以进一步抑制嘌呤从头合成,导致异常的细胞增殖,凋亡 (Apoptosis) 和细胞周期停滞。Lometrexol 具有抗癌活性。Lometrexol 还是一种有效的人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 抑制剂。 | |||
T6501 |
Fludarabine Phosphate
NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨 |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物,与 dATP 竞争,并入到 DNA,可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶,从而中断 DNA 合成并抑制肿瘤细胞生长。 | |||
T14147 |
Pelitrexol
AG 2037 |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor. | |||
T68230 |
Amidox
|
||
Amidox is a ribonucleotide reductase inhibitor. | |||
T11921 |
LY 222306
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM. | |||
T29197 | YZ51 | ||
YZ51, a novel potent inhibitor of ribonucleotide reductase (RR), inhibits hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. | |||
T24980 |
5-DACTHF
543U76,5-Deazacyclotetrahydrofolate |
||
5-DACTHF is an inhibitor of glycinamide ribonucleotide transformylase and aminoimidazole ribonucleotide transformylase used as an anti-purine drug. | |||
T26572 |
AG2034
AG-2034,AG 2034 |
||
AG2034 is an inhibitor of the glycinamide ribonucleotide formyltransferase (GARFT). | |||
T15813 |
LY309887
|
LTR | Immunology/Inflammation |
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity. | |||
TNU0230 | 2’-Azido-2’-deoxycytidine | ||
Nucleoside Derivatives - Azido-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; antiviral agent, DNA synthesis inhibitor; Ribonucleotide reductase inhibitor | |||
T10068 |
2'-Azido-2'-deoxyuridine
N3dUrd |
Others | Others |
2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity. | |||
T11884 | LSN 3213128 | Others | Others |
LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. | |||
T82950 |
ATIC-IN-1
|
||
ATIC-IN-1 (compound 14) 是一种针对ATIC二聚体化的抑制剂,具有Ki值685 nM。ATIC二聚体形成对AICAR转化酶功能是必要的。ATIC-IN-1展现了通过减少细胞数和降低细胞分裂率的抗肿瘤活性。 | |||
T40862 |
Fludarabine triphosphate
三磷酸氟达拉滨,F-ara-ATP |
||
Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate , inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis. | |||
TNU0133 | 3’-Azido-3’-deoxycytidine | ||
Nucleoside Derivatives –Azido-nucleosides, 3’-Modified nucleosides; Drugs and Inhibitors; Ribonucleotide reductase inhibitor | |||
T78814 |
COH1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
COH1为核糖核苷酸还原酶(RR)抑制剂,主要应用于癌症、线粒体疾病和神经退行性疾病的研究领域。 | |||
T36300 |
Uridine-5’-monophosphate (sodium salt hydrate)
|
||
Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) | |||
T76517 |
Herpes virus inhibitor 2
|
||
Herpes virus inhibitor 2 为一种疱疹病毒抑制剂,专门破坏疱疹病毒的核糖核苷酸还原酶四级结构,从而抑制病毒复制。 | |||
T76515 |
Herpes virus inhibitor 1
|
||
Herpes virus inhibitor 1 是一种抑制疱疹病毒的化合物,能破坏疱疹病毒的核糖核苷酸还原酶四级结构,从而抑制病毒复制。 | |||
T15378 |
Gemcitabine elaidate
Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126 |
Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。 | |||
T37106 | 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) | ||
2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations ... | |||
T63240 | Lometrexol disodium | ||
Lometrexol (DDATHF) disodium 是人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 的有效抑制剂,也是抗嘌呤类抗叶酸 (antifolate) 药,能够降低甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性,但不引起可检测水平的 DNA 链断裂。Lometrexol disodium 对嘌呤从头合成具有抑制作用,可造成异常的细胞增殖,凋亡 (apoptosis) 和细胞周期停滞,表现出抗癌效果。 | |||
T74088 | Fludarabine triphosphate trisodium | ||
Fludarabine triphosphate (F-ara-ATP) trisodium 是Fludarabine 的活性代谢物,是一种有效的、非竞争性的、特异性的DNA 引发酶 (DNA primase) 抑制剂,其IC50为 2.3 μM,Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA 聚合酶,导致细胞凋亡 (apoptosis)。 | |||
T41297 | Lometrexol hydrate | ||
Lometrexol hydrate (DDATHF hydrate) 是一种抗嘌呤类抗叶酸 (antifolate) 药,可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性,但不会诱导可检测水平的 DNA 链断裂。Lometrexol hydrate 可以进一步抑制嘌呤从头合成,引起异常的细胞增殖和凋亡,甚至细胞周期停滞。Lometrexol hydrate 具有抗癌活性。Lometrexol hydrate 还是一种有效的人丝氨酸羟甲基转移酶 1/2 (hSHMT1/2) 抑制剂。 | |||
T60401 |
Tezacitabine
|
||
Tezacitabine 是一种抑制细胞生长和细胞毒性的抗代谢物。 Tezacitabine 是一种核苷类似物,具有双重作用机制。 Tezacitabine 不可逆地抑制核糖核苷酸还原酶,并可在复制或修复过程中掺入 DNA,导致 DNA 链终止。 Tezacitabine 在细胞周期的 G1 期和 S 期阻断肿瘤细胞并诱导凋亡细胞死亡。 Tezacitabine 具有治疗白血病和实体瘤的潜力[1][2]。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5073 |
Inosine 5'-monophosphate disodium salt hydrate
Inosine 5'-monophosphate disodium salt,5'-IMP-Na2,肌苷5-单磷酸二钠盐水合物,Disodium 5'-inosinate monohydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Inosine 5'-monophosphate disodium salt hydrate (Inosine 5'-monophosphate disodium salt) 或肌苷酸是次黄嘌呤的核糖核苷酸,是嘌呤合成过程中形成的第一个核苷酸。 | |||
T1705 |
5-Amino-3H-imidazole-4-Carboxamide
4-Amino-5-imidazolecarboxamide,AICA,4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide |
Endogenous Metabolite | Metabolism |
5-Amino-3H-imidazole-4-Carboxamide (AICA) 是一种合成嘌呤(尤其是核碱基腺嘌呤和鸟嘌呤)的重要前体。 | |||
T4685 |
INOSINIC ACID
Inosine 5′-monophosphate,IMP,5'-肌苷酸,I-5'-P |
Endogenous Metabolite | Metabolism |
Inosinic acid (IMP) 是内源性代谢产物。 | |||
T4809 |
Pyrimidine
嘧啶,Metadiazine |
Others; Endogenous Metabolite | Metabolism; Others |
Pyrimidine (Metadiazine) 是内源性代谢产物的一种。 | |||
T4826 |
L-Histidine monohydrochloride monohydrat
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一,即蛋白质的组成部分。 |