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Search Results for " progestin "

23

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39785L	TH5427	NUDIX hydrolase	Metabolism
	TH5427 在 NUDT5 活性和 ADP-核糖代谢中有研究的价值。它阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5是乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
T7537	Norgestimate 炔诺肟酯,诺孕酯	Progesterone Receptor	Others
	Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素，是一种合成的孕激素类似物。它可用作口服的避孕药。
T2567	Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。
T8395	Nomegestrol acetate	Others; Progesterone Receptor	Others
	Nomegestrol acetate 是一种孕酮受体的完全激动剂，是一种高选择性孕激素。
T1541	Drospirenone ZK 3059,屈螺酮,Dihydrospirorenone	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience; Others
	Drospirenone (ZK 3059) 是spironolactone 的类似物，是一种合成的孕酮。
T1102	Mifepristone C-1073,RU486,RU 38486,米非司酮	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; NO Synthase; Autophagy	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Others
	Mifepristone (C-1073) 是一种黄体酮受体和糖皮质激素受体拮抗剂，在体外实验中的 IC50值分别为 0.2 nM 和 2.6 nM。
T5174	Nestoron 醋酸烯诺孕酮,ST-1435,Segesterone Acetate,Nestorone,Elcometrine	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Nestoron (Segesterone Acetate) 是一种高度选择性和有效的孕激素，是一种 19-norprogesterone 衍生物，对progesterone receptors 具有高亲和力和选择性，可用作激素避孕药。
T2597	Norgestrel 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850	Estrogen/progestogen Receptor; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Norgestrel (WY-3707) 是一种孕酮的合成类似物，是一种口服避孕药中常见的化合物，也是一种神经保护性强抗氧化剂，能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。
T30942	Cingestol
	Cingestol is a steroidal progestin of the 19-nortestosterone group that was never marketed.
T33819	Org 2058 O-2058,Org-2058,Org2058
	Org 2058 is a synthetic progestin.
T34141	Promegestone R5020,R-5020,普美孕酮,RU 5020,R 5020,RU-5020
	Promegestone is a progestin medication used in menopausal hormone therapy and in the treatment of gynecological disorders.
T28280	Oxendolone Roxenone,Prostetin
	Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reductase.
T29248	(+)-Norgestrel Dextronorgestrel,L-Norgestrel
	(+)-Norgestrel is a progestin medication for the treatment of birth control pills and in menopausal hormone therapy.
T34302	Retroprogesterone
	Retroprogesterone, a progestin, may be used for menstrual irregularities in adolescence, for the maintenance of threatened pregnancy, and possibly as an ovulation stimulant.
T13763	LY88074 analog 1	Others	Others
	LY88074 analog 1, a benzothiophene compound with nitrogen-containing non-basic side chains, can be utilized either independently or alongside estrogen or progestin. This agent is effective for mitigating post-menopausal symptoms, including osteoporosis, cardiovascular-related pathological conditions, and estrogen-dependent cancer.
T25304	Demegestone R-2453,Lutionex,R 2453,RU 2453,R2453
	Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat luteal insufficiency.
T19697	Norgestomet SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009
	Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromolar) affinity for the glucocorticoid
T19811	Nomegestrol
	Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives.
T5317L	Cridanimod sodium XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101
	Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, cancer cells could be eradicated thro
T39785	TH5427 hydrochloride
	TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
T37647	5α-dihydro Levonorgestrel
	5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.
T69717	Dimethandrolone
	Dimethandrolone (DMA), also known by its developmental code name CDB-1321, is an experimental androgen/anabolic steroid (AAS) and progestogen medication which is under investigation for potential clinical use. Dimethandrolone is an AAS, and hence is an agonist of the androgen receptor, the biological target of androgens like testosterone. It is also a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progestero...
T83666	Kisspeptin-10 (zebrafish) TFA Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10
	Kisspeptin-10是一种在斑马鱼的大脑、卵巢和睾丸中表达的神经肽，参与性腺发育和类固醇表达。在10 ng/ml的浓度下使用时，能提高孤立的斑马鱼卵巢滤泡中编码黄体生成素(luteinizing hormone, Lh)受体，以及孕酮受体a (Progestin receptor a, Pra)和Prb的mRNA水平。在0.1和1 µg/g的剂量下给予时，Kisspeptin-10能在雌性金鱼中增加黄体生成素的血清水平，但在雄性金鱼中则不会。

化合物

Cat.No: T39785L

Target: NUDIX hydrolase

Cat.No: T7537

Synonym: 炔诺肟酯,诺孕酯

Target: Progesterone Receptor

Cat.No: T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Nomegestrol acetate

Cat.No: T8395

Target: Others, Progesterone Receptor

Cat.No: T1541

Synonym: ZK 3059,屈螺酮,Dihydrospirorenone

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, COX

Cat.No: T1102

Synonym: C-1073,RU486,RU 38486,米非司酮

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy

Cat.No: T5174

Synonym: 醋酸烯诺孕酮,ST-1435,Segesterone Acetate,Nestorone,Elcometrine

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Cat.No: T2597

Synonym: 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850

Target: Estrogen/progestogen Receptor, Reactive Oxygen Species

Cat.No: T30942

Cat.No: T33819

Synonym: O-2058,Org-2058,Org2058

Cat.No: T34141

Synonym: R5020,R-5020,普美孕酮,RU 5020,R 5020,RU-5020

Cat.No: T28280

Synonym: Roxenone,Prostetin

Cat.No: T29248

Synonym: Dextronorgestrel,L-Norgestrel

Retroprogesterone

Cat.No: T34302

LY88074 analog 1

Cat.No: T13763

Target: Others

Cat.No: T25304

Synonym: R-2453,Lutionex,R 2453,RU 2453,R2453

Cat.No: T19697

Synonym: SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009

Cat.No: T19811

Cridanimod sodium

Cat.No: T5317L

Synonym: XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101

TH5427 hydrochloride

Cat.No: T39785

5α-dihydro Levonorgestrel

Cat.No: T37647

Dimethandrolone

Cat.No: T69717

Kisspeptin-10 (zebrafish) TFA

Cat.No: T83666

Synonym: Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10

Cat. No.	Product Name	Target	Signaling Pathways
T8094	16-Dehydroprogesterone 16-Dehydroprogesterone,16-去氢黄体酮	Endogenous Metabolite	Metabolism
	16-Dehydroprogesterone 是甾体孕激素。
T1263	Levonorgestrel 左炔诺孕酮,D-Norgestrel	Others; Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Levonorgestrel (D-Norgestrel) 是一种合成孕激素，可作用于孕酮受体。它是一种宫内节育器，可以抑制卵子受精。
T1261	Medroxyprogesterone Acetate Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,醋酸甲羟孕酮,Farlutin,安宫黄体酮,Medroxyprogesterone (acetate)	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Medroxyprogesterone Acetate (Farlutin) 是广泛使用的合成类固醇，与雄激素，孕酮及糖皮质激素受体均有作用。
T16338	Norgestimate metabolite Norelgestromin 17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮	Drug Metabolite	Metabolism
	Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) 是norgestimate 的一种活性代谢物。它是用于避孕贴片的甾体孕激素，与雌激素乙炔雌二醇结合使用。
T1429	17α-Hydroxyprogesterone Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮	Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	17α-Hydroxyprogesterone (17-OHP) 是一种内源性孕激素，其他类固醇激素（包括糖皮质激素，雌激素，和雄激素）生物合成的化学中间体。
T7931	16a,17a-Epoxy-4-Pregnen-3,20-Dione	Others	Others
	16a,17a-Epoxy-4-Pregnen-3,20-Dione 是一种合成孕激素，是黄体酮激素的代谢产物，它通过与黄体酮受体结合发挥作用，已被用于研究孕激素对生殖器官的影响，激素对细胞生长和发育的影响，以及激素对免疫系统的影响。

天然产物

16-Dehydroprogesterone

Cat.No: T8094

Synonym: 16-Dehydroprogesterone,16-去氢黄体酮

Target: Endogenous Metabolite

Cat.No: T1263

Synonym: 左炔诺孕酮,D-Norgestrel

Target: Others, Estrogen/progestogen Receptor, Progesterone Receptor

Medroxyprogesterone Acetate

Cat.No: T1261

Synonym: Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,醋酸甲羟孕酮,Farlutin,安宫黄体酮,Medroxyprogesterone (acetate)

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, Endogenous Metabolite

Norgestimate metabolite Norelgestromin

Cat.No: T16338

Synonym: 17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮

Target: Drug Metabolite

17α-Hydroxyprogesterone

Cat.No: T1429

Synonym: Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

16a,17a-Epoxy-4-Pregnen-3,20-Dione

Cat.No: T7931

Target: Others

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