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225

抑制剂 & 化合物

36

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T77647	Tubulin polymerization-IN-43	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T62121	Tubulin polymerization-IN-3
	Tubulin polymerization-IN-3 是一种有效的微管蛋白聚合抑制剂 (IC50: 3.84 μM)，能够诱导结肠癌细胞凋亡。
T61084	Tubulin polymerization-IN-37
	Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
T79887	Tubulin polymerization-IN-49
	Tubulin polymerization-IN-49 (compound 12d) 是一种抑制微管蛋白聚合的有效化合物。它通过结合到微管蛋白的秋水仙碱位点来抑制其聚合。此外，Tubulin polymerization-IN-49 能够诱导细胞周期在 G2/M 期停滞并触发细胞凋亡，表现出对抗癌的活性，能够预防肿瘤的生成及抑制肿瘤增殖和血管生成。
T61940	Tubulin polymerization-IN-4
	Tubulin polymerization-IN-4 是有效的微管蛋白聚合体 (tubulin polymerization) 抑制剂（IC50=4.6 μM）。Tubulin polymerization-IN-4 可以破坏微管蛋白聚合，将细胞周期阻滞在G2/M 期，诱导细胞凋亡 (apoptosis)，抑制细胞的克隆发生和迁移。Tubulin polymerization-IN-4还可以破坏血管系统。
T62040	Tubulin polymerization-IN-30
	Tubulin polymerization-IN-30 (compound 6e) 是有效的微管蛋白聚合 (Tubulin polymerization) 抑制剂，可破坏细胞内微管组织，将细胞周期阻滞在 G2/M 期。Tubulin polymerization-IN-30 对 HeLa、SGC-7901和A549 等肿瘤细胞系具有良好的抗肿瘤活性，其IC50分别为 0.403、 2.16和2.21 μM。
T63849	Tubulin polymerization-IN-34
	Tubulin polymerization-IN-34 是 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂，能够高度选择边缘区淋巴瘤 VL51 细胞系。
T60735	Tubulin polymerization-IN-22
	Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期，并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。
T61482	Tubulin polymerization-IN-13
	Tubulin polymerization-IN-13 (Compound 4f) is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.37 μM. It displays significant anti-proliferative effects against cancer cells, inducing apoptosis and exhibiting potential antivascular activity [1].
T60936	Tubulin polymerization-IN-24
	Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的微管蛋白聚合抑制剂，可提高 GTP 水解速率并抑制微管组装。Tubulin aggregation-IN-24 诱导细胞凋亡和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 抑制乳腺癌细胞 MCF-7 的增殖。
T79532	Tubulin polymerization-IN-44
	Tubulin polymerization-IN-44 (7w)为具高效性的微管蛋白聚合抑制剂，其IC50为0.21 μM。该化合物可诱发G2/M期阻塞并触发癌细胞凋亡(apoptosis)，适用于肿瘤研究。
T62206	Tubulin polymerization-IN-19
	Tubulin aggregation-IN-19 (compound 4) 是一种有效 tubulin 聚合抑制剂，对乳腺癌和耐药结肠癌表现出研究潜力。
T63836	Tubulin polymerization-IN-7
	Tubulin aggregation-IN-7 是有效的 tubulin 聚合抑制剂，对癌症疾病表现出研究潜力。
T62971	Tubulin polymerization-IN-16
	Tubulin aggregation-IN-16 (compound 5g) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞有效 (IC50: 0.084-0.221 μM)。Tubulin aggregation-IN-16 能有效地破坏微管/管蛋白的动态，诱导 SGC-7901 细胞的细胞周期阻滞在 G2/M 期。
T62498	Tubulin polymerization-IN-20
	Tubulin aggregation-IN-20 (compound 11) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-20 具有潜力进行乳腺癌和耐药结肠癌的研究。
T62369	Tubulin polymerization-IN-17
	Tubulin aggregation-IN-17 (compound 23g) 是一种 tubulin 聚合的有效抑制剂。Tubulin aggregation-IN-17 具有微管蛋白解聚作用，能够诱导细胞凋亡并抑制迁移。Tubulin aggregation-IN-17 具有潜力进行癌症疾病的研究。
T61069	Tubulin polymerization-IN-15
	Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].
T61129	Tubulin polymerization-IN-27
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1].
T60758	Tubulin polymerization-IN-36
	Tubulin polymerization-IN-36 可用于癌症研究，例如淋巴癌。Tubulin polymerization-IN-36 结合微管蛋白的秋水仙碱位点并且抑制秋水碱结合，是一种微管蛋白聚合的抑制剂，IC50值为 2.8 μM。
T79429	Tubulin polymerization-IN-50
	Tubulin polymerization-IN-50（compound 7n）是一种Tubulin polymerization抑制剂，其在SK-Mel-28细胞中的IC50值为5.05 μM，能够诱导(cell cycle)阻滞在G2/M期。
T80922	Tubulin polymerization-IN-56
	Tubulin polymerization-IN-56（compound 8l），一种吲唑衍生的微管蛋白聚合抑制剂，通过与秋水仙碱位点的相互作用，能够引发细胞周期停滞与细胞凋亡。该化合物还能降低细胞迁移并在体内更有效地抑制肿瘤生长。
T72169	Tubulin polymerization-IN-40
	Tubulin polymerization-IN-40为基于吖啶的微管蛋白聚合抑制剂，IC50值为1.5 μM，能在G2/M期阻滞癌细胞并诱导细胞凋亡，同时显示出抗癌活性与免疫增强作用。
T79645	Tubulin polymerization-IN-48
	Tubulin polymerization-IN-48 (Compound 4k) 是一种中等强度破坏微管网络的微管蛋白聚合抑制剂。其对神经母细胞瘤癌细胞增殖的抑制效果显著，Chp-134 细胞系和 Kelly 细胞系的IC50值分别为79 nM和165 nM。
T62477	Tubulin polymerization-IN-18
	Tubulin aggregation-IN-18 (compound 3) 是一种有效的 tubulin 聚合抑制剂，具有潜力进行乳腺癌和耐药结肠癌的研究。
T62135	Tubulin polymerization-IN-25
	Tubulin polymerization-IN-25 是一种选择性的、双重 tubulin polymerization (IC50: 1.11 μM) 和 farnesyl transferase (FTase) (IC50: 0.39 μM) 抑制剂。Tubulin polymerization-IN-25 对癌细胞表现出细胞毒性，能够阻断细胞增殖。
T60902	Tubulin polymerization-IN-31
	Tubulin polymerization-IN-31 (Compound 4c) 具有抗癌活性，并诱导癌细胞凋亡。Tubulin polymerization-IN-31 是微管蛋白聚合的抑制剂，IC50 值为 3.64 μM。
T79766	Tubulin polymerization-IN-52
	Tubulin polymerization-IN-52 (compound SC23)是一种tubulin聚合抑制剂，具有2.9 μM的IC50值。
T61600	Tubulin polymerization-IN-10
	Tubulin polymerization-IN-10 is a highly potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 4.25±0.75 μM. It possesses significant anti-tumor properties [1].
T79268	Tubulin polymerization-IN-42
	Tubulin polymerization-IN-42（compound 10j）是一种具有抗癌活性的吲哚取代呋喃酮类微管蛋白聚合抑制剂。
T61532	Tubulin polymerization-IN-6
	Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Additionally, Tubulin polymerization-IN-6 has been found to effectively hinder tumor growth in HT29 xenograft Balb/c nude mice [1].
T63580	Tubulin polymerization-IN-21
	Tubulin polymerization-IN-21 是微管蛋白聚合抑制剂，能够破坏细胞完整性和影响葡萄糖代谢，具有抗癌作用。
T63111	Tubulin polymerization-IN-33
	Tubulin polymerization-IN-33 是一种 [1,2] 恶唑洛异吲哚微管蛋白聚合的抑制剂，能够较好的抗 NCI 系列癌细胞的增殖。
T62349	Tubulin polymerization-IN-8
	Tubulin aggregation-IN-8 (compound IIc) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-8 浓度依赖性地导致 HCT116 肿瘤细胞 G2/M 期细胞周期停滞，并显示显着抑制微管蛋白聚合，IC50值为 12.7 μM。Tubulin aggregation-IN-8 具有研究癌症疾病的潜力。
T80923	Tubulin polymerization-IN-53
	Tubulin polymerization-IN-53 是一种β-tubulin聚合的抑制剂，能够阻断细胞周期于G2/M阶段。对MDA-MB-231细胞系显示出抗增殖作用，其IC50为3.24 μM。
T60802	Tubulin polymerization-IN-2
	Tubulin polymerization-IN-2 为针对β-微管蛋白的强效抗癌分子，IC50 值为0.92 μM。该分子在多种细胞系中，包括白血病、非小细胞肺癌、肾癌、前列腺癌及乳腺癌细胞中展现出显著的抑制效果。
T72167	Tubulin polymerization-IN-39
	Tubulin polymerization-IN-39，一种以IC50为4.9μM抑制微管蛋白聚合，通过占据秋水仙碱结合位点来实现其作用。此外，Tubulin polymerization-IN-39能有效抑制癌细胞增殖。
T62693	Tubulin polymerization-IN-29
	Tubulin polymerization-IN-29 是一种有效的微管蛋白聚合抑制剂，显示出有效的抗增殖效果。Tubulin polymerization-IN-29 能够诱导 HeLa 细胞的细胞周期阻滞在 G2/M 期。
T62217	Tubulin polymerization-IN-9
	Tubulin polymerization-IN-9 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 1.82 μM)。Tubulin polymerization-IN-9 能够将 K562 细胞的细胞周期停滞在 G2/M 期，并诱导其凋亡 (apoptosis) 及线粒体去极化。Tubulin polymerization-IN-9 表现出强大的抗血管和抗肿瘤作用。
T63611	Tubulin polymerization-IN-32
	Tubulin polymerization-IN-32 是微管蛋白 (tubulin) 聚合抑制剂，能够抑制癌细胞增殖，可用于研究淋巴瘤等癌症。
T63725	Tubulin polymerization-IN-35
	Tubulin polymerization-IN-35 是 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂，能够高度选择性作用于边缘区淋巴瘤 VL51 细胞系。
T61880	Tubulin polymerization-IN-26
	Tubulin polymerization-IN-26 (compound 12h) is a chemical compound that inhibits the polymerization of microtubulin. It achieves this by binding to the colchicine binding site of microtubulin, with an IC50 value of 4.64 μM. Additionally, Tubulin polymerization-IN-26 has the ability to induce apoptosis and inhibit cell metastasis or migration. Due to these properties, it holds potential as a valuable compound for researching lung cancer [1].
T80924	Tubulin polymerization-IN-51
	Tubulin polymerization-IN-51（compound 7u）是抑制SK-Mel-28细胞微管蛋白聚合的化合物，IC50介于2.55至17.89μM。该化合物适用于癌症研究。
T60600	Tubulin polymerization-IN-14
	Tubulin polymerization-IN-14 (Compound 20a) 是一种微管蛋白聚合抑制剂(IC 50 = 3.15 μM) ，具有强大的抗血管和抗癌活性，包括诱导癌细胞凋亡。
T79341	Tubulin polymerization-IN-45
	Tubulin polymerization-IN-45 是针对微管蛋白的靶向抑制剂，通过与微管蛋白秋水仙碱结合位点相结合，能够诱导肝细胞癌细胞 (HCC) 发生细胞凋亡 (apoptosis)。
T79629	Tubulin polymerization-IN-46
	Tubulin polymerization-IN-46（compound 9q）是一种微管蛋白抑制剂，能够阻断微管蛋白聚合并诱发细胞凋亡。该化合物通过抑制有丝分裂，导致MCF-7细胞在G2/M期停滞，对MCF-7乳腺癌细胞展现出抗增殖效果，其IC50值为10 nM。
T2164	Wiskostatin	Others	Others
	Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂，能够不可逆的使细胞 ATP 水平快速下降。
T9504	MAP4343	Microtubule Associated	Cytoskeletal Signaling
	MAP4343 是孕烯醇酮的 3-甲基醚衍生物。它在体外与微管相关蛋白 2 (MAP2) 结合并刺激微管蛋白聚合，从而增强神经突延伸和保护神经元免受神经毒剂的侵害。
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。

化合物

Tubulin polymerization-IN-43

Cat.No: T77647

Target: Apoptosis, Microtubule Associated

Tubulin polymerization-IN-47

Cat.No: T77651

Target: Microtubule Associated

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Tubulin polymerization-IN-3

Cat.No: T62121

Tubulin polymerization-IN-37

Cat.No: T61084

Tubulin polymerization-IN-49

Cat.No: T79887

Tubulin polymerization-IN-4

Cat.No: T61940

Tubulin polymerization-IN-30

Cat.No: T62040

Tubulin polymerization-IN-34

Cat.No: T63849

Tubulin polymerization-IN-22

Cat.No: T60735

Tubulin polymerization-IN-13

Cat.No: T61482

Tubulin polymerization-IN-24

Cat.No: T60936

Tubulin polymerization-IN-44

Cat.No: T79532

Tubulin polymerization-IN-19

Cat.No: T62206

Tubulin polymerization-IN-7

Cat.No: T63836

Tubulin polymerization-IN-16

Cat.No: T62971

Tubulin polymerization-IN-20

Cat.No: T62498

Tubulin polymerization-IN-17

Cat.No: T62369

Tubulin polymerization-IN-15

Cat.No: T61069

Tubulin polymerization-IN-27

Cat.No: T61129

Tubulin polymerization-IN-36

Cat.No: T60758

Tubulin polymerization-IN-50

Cat.No: T79429

Tubulin polymerization-IN-56

Cat.No: T80922

Tubulin polymerization-IN-40

Cat.No: T72169

Tubulin polymerization-IN-48

Cat.No: T79645

Tubulin polymerization-IN-18

Cat.No: T62477

Tubulin polymerization-IN-25

Cat.No: T62135

Tubulin polymerization-IN-31

Cat.No: T60902

Tubulin polymerization-IN-52

Cat.No: T79766

Tubulin polymerization-IN-10

Cat.No: T61600

Tubulin polymerization-IN-42

Cat.No: T79268

Tubulin polymerization-IN-6

Cat.No: T61532

Tubulin polymerization-IN-21

Cat.No: T63580

Tubulin polymerization-IN-33

Cat.No: T63111

Tubulin polymerization-IN-8

Cat.No: T62349

Tubulin polymerization-IN-53

Cat.No: T80923

Tubulin polymerization-IN-2

Cat.No: T60802

Tubulin polymerization-IN-39

Cat.No: T72167

Tubulin polymerization-IN-29

Cat.No: T62693

Tubulin polymerization-IN-9

Cat.No: T62217

Tubulin polymerization-IN-32

Cat.No: T63611

Tubulin polymerization-IN-35

Cat.No: T63725

Tubulin polymerization-IN-26

Cat.No: T61880

Tubulin polymerization-IN-51

Cat.No: T80924

Tubulin polymerization-IN-14

Cat.No: T60600

Tubulin polymerization-IN-45

Cat.No: T79341

Tubulin polymerization-IN-46

Cat.No: T79629

Cat.No: T2164

Target: Others

Cat.No: T9504

Target: Microtubule Associated

Cat.No: T23372

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8211	(±)-Decursinol 紫花前胡醇,3',4'-dihydro-3'-hydroxy-Xanthyletin	Others; Antibacterial	Microbiology/Virology; Others
	(±)-Decursinol (3',4'-dihydro-3'-hydroxy-Xanthyletin) 是来自当归的一种 FtsZ 抑制剂，抑制 B. anthracis 的 FtsZ 聚合，IC50为 102 μM。
T0320	Colchicine 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。
T4821	Tetrahydro-2H-pyran-2-one δ-Valerolactone,δ-Valeryllactone,delta-戊内酯,2-Oxotetrahydropyran	Others; Endogenous Metabolite	Metabolism; Others
	Tetrahydro-2H-pyran-2-one (δ-Valerolactone) 是内源性代谢产物的一种。
T19720	Colcemid C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine	Microtubule Associated	Cytoskeletal Signaling
	Colcemid (NSC-3096) 是一种微管聚合抑制剂，可诱导细胞凋亡，可用于肿瘤和胚胎克隆的研究。
TN6706	3-demethylcolchicine 3-去甲秋水仙碱,3-去甲基秋水仙碱	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	3-Demethylcolchicine 是一种从金莲花中分离得到的天然产物，对纯化的牛脑微管蛋白的聚合有抑制作用。
T5791	Fructo-oligosaccharide DP7/GF6 Fructoheptasaccharide,蔗果七糖	Others	Others
	Fructo-oligosaccharide DP7/GF6 (Fructoheptasaccharide) 属于一种聚果糖，聚合度 (DP=7)。其中 Fructo-oligosaccharides (FOS) 由 6 个果糖单元通过 (2→1)-β-糖苷键连接，并在非还原性末端具有 1 个 D-葡萄糖单元。
TP1180	Dolastatin 10 尾海兔素10,NSC 376128,DLS 10	Microtubule Associated	Cytoskeletal Signaling
	Dolastatin 10 (DLS 10) 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。
T22262	Ansamitocin p-3 Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222	Microtubule Associated	Cytoskeletal Signaling
	Ansamitocin p-3 (Maytansinol isobutyrate) 是一种微管抑制剂，对微管蛋白聚合的 IC50 为 3.4 μM。
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
T7916	4-Acetamidobenzenesulfonyl azide	Others	Others
	4-Acetamidobenzenesulfonyl azide 用于各种科学研究应用，包括药物、肽和其他生物活性分子的合成，也被用作聚合反应和聚合物合成中的催化剂。
TN2401	Ethyl glucoside β-D-Glucopyranoside, ethyl,Ethyl D-glucoside	Others	Others
	Ethyl glucoside (β-D-Glucopyranoside, ethyl) 是一种用于水基钻井液的页岩抑制剂，是酶催化区域选择性内酯开环聚合的多功能引发剂，是一种存在于 Sisyrinchium palmifolium 的天然化合物。
T8154	Fructo-oligosaccharide DP9/GF8 Fructo-oligosaccharide DP9 / GF8,蔗果九糖	Others	Others
	Fructo-oligosaccharide DP9/GF8 (Fructo-oligosaccharide DP9 / GF8) 是一种低聚果糖(FOS)，其聚合度DP=9。低聚果糖(FOS)由 8 个果糖单元通过 (2→1)-β-糖苷键连接，并在非还原性末端具有 1 个 D-葡萄糖单元。
T6272	Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂，是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。
TN2376	Fructo-oligosaccharide DP8/GF7 蔗果八糖,Fructo-oligosaccharide DP8 / GF7	Others	Others
	Fructo-oligosaccharide DP8/GF7 (Fructo-oligosaccharide DP8 / GF7) 是一种聚果糖，聚合度(DP=8)。Fructo-oligosaccharides 由 7 个果糖单元通过 (2→1)-β-糖苷键连接，并在非还原性末端具有 1 个 D-葡萄糖单元。
T4840	3-Hydroxybenzoic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxybenzoic acid 是内源性代谢产物的一种。
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
T82369	Fructo-oligosaccharide DP14
	Fructo-oligosaccharide DP14为从Atractylodes lancea中提取的寡糖。
T10928	Cytochalasin A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy
T75646	Moroidin
	Moroidin是一种双环八肽，隶属于荨麻疹科环肽科，有效抑制纯化的微管蛋白聚合，表现为微管蛋白聚合抑制剂。此外，Moroidin对包括A549人肺癌细胞在内的多种癌细胞显示出细胞毒性作用，能诱导细胞凋亡。
T19328	Fructo-oligosaccharide DP11/GF10	Others	Others
	Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) compound with a degree of polymerization (DP) equal to 11. FOS consists of 10 fructose units connected by (2→1)-β-glycosidic bonds, with a single D-glucosyl unit present at the non-reducing end.
TN2358	Fructo-oligosaccharide DP10/GF9 蔗果十糖,Fructo-oligosaccharide DP10/GF9	Others	Others
	Fructo-oligosaccharide DP10/GF9 is a compound classified as a fructooligosaccharide (FOS) with a degree of polymerization (DP) of 10. FOS consists of a chain of 9 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end.
T82787	Calythropsin
	Calythropsin是一种对有丝分裂产生微弱影响的细胞毒性查尔酮类化合物，该化合物可能还会影响微管蛋白的聚合。
T82857	Blestriarene B (-)-Blestriarene B
	(-)-Blestriarene B 是一种从白芨（兰科）中分离得到的二苯乙烯类化合物，其通过抑制微管蛋白的聚合作用发挥效用。
T13944	Tubulysin M	Others	Others
	Tubulysin M is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin M is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13941	Tubulysin G	Others	Others
	Tubulysin G is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin G is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13940	Tubulysin F	Others	Others
	Tubulysin F is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin F is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T15721	Latrunculin A LAT-A	Others	Others
	Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re
T19329	Fructo-oligosaccharide DP12/GF11 蔗果十二糖	Others	Others
	Fructo-oligosaccharide DP12/GF11 is a member of fructooligosaccharides (FOS) characterized by a degree of polymerization (DP) of 12. FOS compounds consist of 11 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end.
T13942	Tubulysin H	Others	Others
	Tubulysin H is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin H is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13943	Tubulysin I	Others	Others
	Tubulysin I is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to c
T82241	Halichondrin B
	Halichondrin B，源自海绵 Halichondria okadai，为非竞争性Vinca-alkaloid 微管蛋白结合抑制剂，微管蛋白聚合 IC50 值为1.2-1.4 μM，表现出抗肿瘤活性。
T20636	Latrunculin B LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644	Antifungal	Microbiology/Virology
	Latrunculin B 是一种来自红海海绵的生物碱，是一种肌动蛋白聚合 (actin polymerization) 抑制剂，具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生，可用于研究青少年青光眼。
T73206	Wikstrol A
	Wikstrol A 是一种有效的抗真菌剂、抗有丝分裂剂和抗HIV-1剂。Wikstrol A 诱导稻瘟病菌菌丝体的形态变形，MMDC 值为 70.1 µM。Wikstrol 对微管聚合具有活性，IC50值为 131 µM。Wikstrol A 显示抗HIV-1活性，IC50值为 67.8 µM。
T78467	trans-10-Heptadecenoic acid
	trans-10-Heptadecenoic acid 是一种能在特定酶作用下参与生物合成与代谢过程的反式脂肪酸。在 2,4-二烯酰基-CoA 还原酶与 Delta3,Delta2-烯酰基-CoA 异构酶催化下，trans-10-Heptadecenoic acid 可合成聚羟基链烷酸酯。当缺乏 2,4-二烯酰基-CoA 还原酶时，该化合物则经由多功能酶 (MFE) 中的烯酰辅酶 A 水合酶 II 进行降解。此外，trans-10-Heptadecenoic acid 能通过还原酶依赖性与直接 MFE 依赖性途径引起细胞内的碳外流。
T11712	Jasplakinolide Jaspamide,NSC-613009	Microtubule Associated; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。

天然产物

(±)-Decursinol

Cat.No: T8211

Synonym: 紫花前胡醇,3',4'-dihydro-3'-hydroxy-Xanthyletin

Target: Others, Antibacterial

Cat.No: T0320

Synonym: 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol

Target: Apoptosis, Microtubule Associated, Autophagy

Tetrahydro-2H-pyran-2-one

Cat.No: T4821

Synonym: δ-Valerolactone,δ-Valeryllactone,delta-戊内酯,2-Oxotetrahydropyran

Target: Others, Endogenous Metabolite

Cat.No: T19720

Synonym: C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine

Target: Microtubule Associated

3-demethylcolchicine

Cat.No: TN6706

Synonym: 3-去甲秋水仙碱,3-去甲基秋水仙碱

Target: Reactive Oxygen Species

Fructo-oligosaccharide DP7/GF6

Cat.No: T5791

Synonym: Fructoheptasaccharide,蔗果七糖

Target: Others

Cat.No: TP1180

Synonym: 尾海兔素10,NSC 376128,DLS 10

Target: Microtubule Associated

Ansamitocin p-3

Cat.No: T22262

Synonym: Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222

Target: Microtubule Associated

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

4-Acetamidobenzenesulfonyl azide

Cat.No: T7916

Target: Others

Ethyl glucoside

Cat.No: TN2401

Synonym: β-D-Glucopyranoside, ethyl,Ethyl D-glucoside

Target: Others

Fructo-oligosaccharide DP9/GF8

Cat.No: T8154

Synonym: Fructo-oligosaccharide DP9 / GF8,蔗果九糖

Target: Others

Fosbretabulin Disodium

Cat.No: T6272

Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Target: Apoptosis, Microtubule Associated

Fructo-oligosaccharide DP8/GF7

Cat.No: TN2376

Synonym: 蔗果八糖,Fructo-oligosaccharide DP8 / GF7

Target: Others

3-Hydroxybenzoic acid

Cat.No: T4840

Target: Others, Endogenous Metabolite

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

19-O-Acetylchaetoglobosin A

Cat.No: T35609

Fructo-oligosaccharide DP14

Cat.No: T82369

Cat.No: T10928

Target: HIV Protease

Cat.No: T75646

Fructo-oligosaccharide DP11/GF10

Cat.No: T19328

Target: Others

Fructo-oligosaccharide DP10/GF9

Cat.No: TN2358

Synonym: 蔗果十糖,Fructo-oligosaccharide DP10/GF9

Target: Others

Cat.No: T82787

Cat.No: T82857

Synonym: (-)-Blestriarene B

Cat.No: T13944

Target: Others

Cat.No: T13941

Target: Others

Cat.No: T13940

Target: Others

Cat.No: T15721

Synonym: LAT-A

Target: Others

Fructo-oligosaccharide DP12/GF11

Cat.No: T19329

Synonym: 蔗果十二糖

Target: Others

Cat.No: T13942

Target: Others

Cat.No: T13943

Target: Others

Cat.No: T82241

Cat.No: T20636

Synonym: LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644

Target: Antifungal

Cat.No: T73206

trans-10-Heptadecenoic acid

Cat.No: T78467

Cat.No: T11712

Synonym: Jaspamide,NSC-613009

Target: Microtubule Associated, Antifungal

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