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19

抑制剂 & 化合物

7

天然产物

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Cat. No. Product Name Target Signaling Pathways
T1111 Pralidoxime Chloride

2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)

AChE Neuroscience
Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物,对中毒乙酰胆碱酯酶具有恢复作用,可用于有机磷中毒的研究。
T32046 HBED

CHELII,CHEL II,CHEL-II

Others Others
HBED (CHELII) 是一种铁螯合剂,可用于治疗慢性铁过载和急性铁中毒的研究。
T22321 edetate calcium disodium

EDTA calcium disodium,乙二胺四乙酸二钠钙

Others Others
Edetate calcium disodium(EDTA calcium disodium) 是一种螯合剂,主要用于治疗严重的铅中毒。
T0765 Fomepizole

Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol

P450; CAT; AChR Metabolism; Neuroscience; oxidation-reduction
Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。
T19084 1-Naphthyl acetate

AChE Neuroscience
1-Naphthyl acetate 是一种有吸引力的生色底物,用于检测红细胞乙酰胆碱酯酶的活性。它具有检测有机磷农药中毒的潜力。
T16949 Sucrose octaacetate

Others Others
Sucrose octaacetate 是蔗糖的乙酰化衍生物,具有强烈的苦味,可用作苦味替代品。它可用作食品添加剂,还可用作粘合剂和增塑剂。它也可用作软模板,以合成聚苯胺纳米纤维。它还用于许多农药,杀虫剂和其他有毒产品中,以防止意外中毒。
T0006 Methylene Blue trihydrate

碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶,单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药,在医疗中通常用作染料。它具有抗伤害感受,抗疟疾,抗抑郁和抗焦虑作用,可用于高铁血红蛋白血症,神经退行性疾病和异环磷酰胺引起的脑病的研究。
T22404 Pralidoxime Iodide

2-PAM,碘解磷定

Others Others
Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
T69079 Trimedoxime bromide

Trimedoxime bromide is a cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.
T16372 Obidoxime dichloride

Others Others
Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
T32074 Hgg 12

Hgg-12,Hgg12

Hgg 12 is used to treat organophosphorus poisoning.
T20118 L-Penicillamine

L-Penicillamine is a medication primarily. It is used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, copper poisoning, and lead poisoning.
T24538 N-Monoacetylcystine

Parvolex,N-Acetylcystine

N-Monoacetylcystine is a paracetamol poisoning antidote. It is used in the treatment of influenza A virus pandemic.
T62857 K203

K203 是一种有效的 tabun 抑制的 AChE 再激活剂,是一种重要的有机磷中毒解毒剂。
T73060 Pralidoxime

Pralidoxime 是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂。Pralidoxime 通过肟部分对结合神经毒剂磷中心的亲核攻击,重新激活受神经毒剂抑制的 AChE。Pralidoxime 是一种有机磷中毒的解毒剂。
T82551 Dinophysistoxin 1

DTX 1

Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) 为腹泻性贝类中毒病原体,并表现出促进肿瘤活性,同时亦作为一种皮肤刺激物。
T69193 SN-28049

SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049.
T72245 Fomepizole hydrochloride

4-Methylpyrazole hydrochloride

Fomepizole hydrochloride(4-Methylpyrazole)是一种高效、具口服活性的细胞色素P450(CYP2E1)和竞争性乙醇脱氢酶(alcohol dehydrogenase)抑制剂,阻止甲醇和乙二醇转化为有毒代谢产物,具有用于乙二醇或甲醇中毒解毒的潜力。
T35772 Emestrin

Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr...

化合物

Pralidoxime Chloride
Cat.No: T1111
Synonym: 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)
Target: AChE
HBED
Cat.No: T32046
Synonym: CHELII,CHEL II,CHEL-II
Target: Others
edetate calcium disodium
Cat.No: T22321
Synonym: EDTA calcium disodium,乙二胺四乙酸二钠钙
Target: Others
Fomepizole
Cat.No: T0765
Synonym: Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol
Target: P450, CAT, AChR
1-Naphthyl acetate
Cat.No: T19084
Synonym:
Target: AChE
Sucrose octaacetate
Cat.No: T16949
Synonym:
Target: Others
Methylene Blue trihydrate
Cat.No: T0006
Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Pralidoxime Iodide
Cat.No: T22404
Synonym: 2-PAM,碘解磷定
Target: Others
Trimedoxime bromide
Cat.No: T69079
Synonym:
Target:
Obidoxime dichloride
Cat.No: T16372
Synonym:
Target: Others
Hgg 12
Cat.No: T32074
Synonym: Hgg-12,Hgg12
Target:
L-Penicillamine
Cat.No: T20118
Synonym:
Target:
N-Monoacetylcystine
Cat.No: T24538
Synonym: Parvolex,N-Acetylcystine
Target:
K203
Cat.No: T62857
Synonym:
Target:
Pralidoxime
Cat.No: T73060
Synonym:
Target:
Dinophysistoxin 1
Cat.No: T82551
Synonym: DTX 1
Target:
SN-28049
Cat.No: T69193
Synonym:
Target:
Fomepizole hydrochloride
Cat.No: T72245
Synonym: 4-Methylpyrazole hydrochloride
Target:
Emestrin
Cat.No: T35772
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T7438 3,5-Dimethoxyphenol

Phloroglucinol dimethyl ether,3,5-二甲氧基苯酚

Tyrosinase Proteases/Proteasome
3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) 是一种存在于人类食用红豆杉的叶子中的毒素代谢物。
T1396 Bemegride

贝美格,Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Bemegride (3-Ethyl-3-methylglutarimide) 是一种中枢神经系统兴奋剂和巴比妥类中毒的解毒剂。
T3S1888 Deltaline

德尔塔林,Deltamine 6-acetate,Eldelin

Others Others
Deltaline (Eldelin) 是一种从滇川翠雀花属植物中分离出来的二萜类生物碱。它可用于缓解疼痛的研究,滇川翠雀花属植物也被用于风湿痛、中风引起的麻痹、类风湿性关节炎的研究。
T21532 Anisodamine

6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

AChR Neuroscience
Anisodamine (6-beta-Hydroxyhyoscyamine) 是毒蕈碱和烟碱胆碱受体的拮抗剂,对毒蕈碱受体的亲和力与东莨菪碱和阿托品相似。 Anisodamine 改善休克状态下的微循环,可用于有机磷中毒的研究。
T16726 Rebeccamycin

Topoisomerase DNA Damage/DNA Repair
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
TN1749 Huperzine C

Others Others
Huperzine has the value as pretreatment of organophosphate poisoning, it can be used as a protective agent against organophosphate intoxication.
T36068 Brevetoxin B

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

3,5-Dimethoxyphenol
Cat.No: T7438
Synonym: Phloroglucinol dimethyl ether,3,5-二甲氧基苯酚
Target: Tyrosinase
Bemegride
Cat.No: T1396
Synonym: 贝美格,Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon
Target: GABA Receptor
Deltaline
Cat.No: T3S1888
Synonym: 德尔塔林,Deltamine 6-acetate,Eldelin
Target: Others
Anisodamine
Cat.No: T21532
Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine
Target: AChR
Rebeccamycin
Cat.No: T16726
Synonym:
Target: Topoisomerase
Huperzine C
Cat.No: TN1749
Synonym:
Target: Others
Brevetoxin B
Cat.No: T36068
Synonym:
Target:
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