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42

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11526	DPP-IV-IN-2 H-Lys(4-nitro-Z)-pyrrolidide	DPP-4	Proteases/Proteasome
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) 是二肽基肽酶 IV 和DP8/9的抑制剂， IC50分别为 0.1 和 0.95 μM。
T1502	Vildagliptin 维达列汀,NVP-LAF 237,维格列汀,LAF237	Apoptosis; Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Vildagliptin (LAF237) 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。
T25340	Diprotin A Ile-Pro-Ile,抑二肽素A	DPP-4	Proteases/Proteasome
	Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
T78410	Gly-Pro-AMC hydrobromide Gly-Pro-AMC HCl
	Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) 为特异性荧光染料，用于细胞荧光检测，检测 Dipeptidyl peptidase IV (DPP-IV) 活性。
T36583	Gly-Pro-pNA hydrochloride Gly-Pro p-nitroanilide hydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride)是一种二肽基肽酶抑制剂，对二肽基肽酶II、二肽基肽酶IV和二肽基肽酶IX具有抑制作用。
T67852	Linagliptin Methyldimer	Proteasome	Proteases/Proteasome; Ubiquitination
	Linagliptin Methyldimer 是一种强效的二肽基肽酶 IV 抑制剂，IC50=6 pM。
T78223	γ-Glu-Tyr gamma-Glutamyltyrosine,gamma-GLU-TYR
	γ-Glu-Tyr (gamma-Glutamyltyrosine) 是一种对二肽基肽酶-IV (DPP-IV) 具有竞争性抑制作用的 kokumi 肽，可用于研究糖尿病。
T68053	Denagliptin GW823093	DPP-4	Proteases/Proteasome
	Denagliptin是一种小分子二肽基肽酶IV（DPP-4）抑制剂，可用于治疗内分泌于代谢疾病，可用于研究2型糖尿病。
T21979	P32/98 (hemifumarate)
	P32/98 hemifumarate 为二肽基肽酶 IV (DPP4) 抑制剂，可在Zucker糖尿病大鼠模型中改善葡萄糖耐量、提高胰岛素敏感性及增强β细胞反应性，具有预防2型糖尿病的潜力。
T8550	NDMC101	Others; NF-κB; Proteasome	NF-κB; Others; Proteases/Proteasome; Ubiquitination
	NDMC101 是有效的破骨细胞形成抑制剂，通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似，通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究，如类风湿关节炎、滑膜炎等。
T27353	Fotagliptin
	Fotagliptin is a dipeptidyl peptidase IV inhibitor.
T25341	Diprotin B
	Diprotin B is a dipeptidyl peptidase IV inhibitor.
T22886	K 579	Others	Others
	K 579 is a dipeptidyl peptidase IV inhibitor.
T11049	Diprotin A TFA Ile-Pro-Pro (TFA)	Others	Others
	Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
T26850	BMS-538305 HCl BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride
	BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV).
T31378	Denagliptin tosylate GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093
	Denagliptin (GW823093 or GSK-823093) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
T11450	Gosogliptin PF-00734200,PF-734200	Others	Others
	Gosogliptin is a potent and selective dipeptidyl peptidase-IV (DPP-IV) inhibitor.
T10082	DPP-IV-IN-1	Others	Others
	DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).
T13826	Prodipine hydrochloride	Others	Others
	Prodipine hydrochloride for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit (IC50 of 4.5 μM and 30 μM, respectively).
T70254	FE-999011
	FE-999011 is a dipeptidyl peptidase IV inhibitor.
T26941	Camegliptin RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579
	Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.
T27598	Imigliptin Dihydrochloride Imigliptin
	Imigliptin Dihydrochloride, a selective dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type II diabetes.
T79911	O-Benzoylhydroxylamine
	O-Benzoyloxyamine 为一种DPP-IV 抑制剂，具备抗糖尿病功能。
T63698	PK44 phosphate
	PK44 phosphate 是二肽基肽酶 IV (DPP-IV) 的有效抑制剂 (IC50: 15.8 nM)。
T62019	Sheng Gelieting
	Sheng Gelieting (CGT-8012) 是二肽基肽酶-IV 酶(DP-IV)抑制剂，IC50值为 87 nM。Sheng Gelieting 可用于研究二肽基肽酶-IV 酶相关的疾病，如糖尿病，特别是 II 型糖尿病。
T22747	DPPI 1c hydrochloride	Others	Others
	DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (IC50 = 104 nM) that shows selectivity over enzymes with DPP-like activity (IC50 > 30 μM).
T39481	NVP-DPP728 dihydrochloride NVP-DPP728 dihydrochloride
	NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
T82178	H-Pro-Pro-Gln-OH
	H-Pro-Pro-Gln-OH 是一寡肽，表现出对二肽基肽酶 IV (DPP-IV) 的显著抑制作用。
T13069	Talabostat isomer mesylate	Others	Others
	Talabostat isomer mesylate is an isomer of talabostat mesylate. Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available inhibitor of dipeptidyl peptidase IV (DPP-IV)(Ki of 0.18 nM).
T61076	Vildagliptin dihydrate
	Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional oral bioavailability and significant antihyperglycemic activity [1].
T63964	DPP-4/GPR119 modulator 2
	DPP-4/GPR119 modulator 2 是二肽基肽酶 IV (DPP-IV) 抑制剂 (IC50: 0.22 μM)，也是一种 GPR119 激动剂 (EC50: 0.95 μM)。DPP-4/GPR119 modulator 2 能够用于研究糖尿病。
T68863	MK-0626 free base
	MK-0626 is a Dipeptidyl peptidase IV (DPP-4) inhibitor, improving neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression.
T61414	DPP-4 inhibitor 3
	DPP-4 inhibitor 3 (Compound 5a) 是一种有效的二肽基肽酶 IV (DPP-IV) 抑制剂，IC50为 0.75 nM。DPP-4 inhibitor 3 具有极好的抗氧化和胰岛素性活性。
T68652	Carmegliptin dihydrochloride
	Carmegliptin dihydrochloride is the salt form of Camegliptin (free base), also known as RG-1579 and RO4876904, a dipeptidyl peptidase IV (DPP-4) inhibitor potentially for the treatment of type 2 diabetes.
T38771	P32/98 P32/98
	P32/98 is a potent inhibitor of dipeptidyl peptidase IV . P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impaired glucose tolerance).
T74978	DPP IV/hCA II-IN-1
	DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂，抑制 DPP IV 的 IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的 Ki 值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。
T68491	Melogliptin
	Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0.75 percent in patients receiving 50mg twice daily dose and 0.60 percent in patients receiving 100 mg once daily dose.
T21691	NVP DPP 728 dihydrochloride
	NVP-DPP728 是一种有效、可逆、腈依赖性二肽基肽酶 IV (DPP-IV)抑制剂，Ki 值为 11 nM。NVP-DPP728 可抑制胰高血糖素样肽-1 (GLP-1)的降解，从而增强响应于葡萄糖摄入的胰岛素释放。NVP-DPP728 可用于糖尿病研究。
T74528	DPP-4/GPR119 modulator 1
	DPP-4/GPR119 modulator 1 (Compound 22) 是一种具有口服活性的二肽基肽酶 IV (DPP-IV) 抑制剂和 GPR119激动剂。DPP-4/GPR119 modulator 1 具有降血糖作用，抑制hERG 通道，IC50值为 4.9 µM。DPP-4/GPR119 modulator 1 可用于糖尿病的研究。
T73875	Fotagliptin benzoate
	Fotagliptin benzoate，作为一种二肽基肽酶IV (DPP-4) 抑制剂（IC50=2.27 nM），在大鼠和狗中展现了安全性，适用于2型糖尿病的研究。
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...
T81025	Teduglutide TFA ALX-0600 TFA
	Teduglutide TFA 是一种具有耐受二肽基肽酶 IV 的胰高血糖素样肽 2 (GLP-2) 类似物，与肠道黏膜营养作用相关。它可用于研究短肠综合征 (SBS) 和克罗恩病 (CD)。

化合物

Cat.No: T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Target: DPP-4

Cat.No: T1502

Synonym: 维达列汀,NVP-LAF 237,维格列汀,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

Cat.No: T25340

Synonym: Ile-Pro-Ile,抑二肽素A

Target: DPP-4

Gly-Pro-AMC hydrobromide

Cat.No: T78410

Synonym: Gly-Pro-AMC HCl

Gly-Pro-pNA hydrochloride

Cat.No: T36583

Synonym: Gly-Pro p-nitroanilide hydrochloride

Target: Proteasome

Linagliptin Methyldimer

Cat.No: T67852

Target: Proteasome

Cat.No: T78223

Synonym: gamma-Glutamyltyrosine,gamma-GLU-TYR

Cat.No: T68053

Synonym: GW823093

Target: DPP-4

P32/98 (hemifumarate)

Cat.No: T21979

Cat.No: T8550

Target: Others, NF-κB, Proteasome

Cat.No: T27353

Cat.No: T25341

Cat.No: T22886

Target: Others

Cat.No: T11049

Synonym: Ile-Pro-Pro (TFA)

Target: Others

Cat.No: T26850

Synonym: BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride

Denagliptin tosylate

Cat.No: T31378

Synonym: GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093

Cat.No: T11450

Synonym: PF-00734200,PF-734200

Target: Others

Cat.No: T10082

Target: Others

Prodipine hydrochloride

Cat.No: T13826

Target: Others

Cat.No: T70254

Cat.No: T26941

Synonym: RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579

Imigliptin Dihydrochloride

Cat.No: T27598

Synonym: Imigliptin

O-Benzoylhydroxylamine

Cat.No: T79911

Cat.No: T63698

Sheng Gelieting

Cat.No: T62019

DPPI 1c hydrochloride

Cat.No: T22747

Target: Others

NVP-DPP728 dihydrochloride

Cat.No: T39481

Synonym: NVP-DPP728 dihydrochloride

H-Pro-Pro-Gln-OH

Cat.No: T82178

Talabostat isomer mesylate

Cat.No: T13069

Target: Others

Vildagliptin dihydrate

Cat.No: T61076

DPP-4/GPR119 modulator 2

Cat.No: T63964

MK-0626 free base

Cat.No: T68863

DPP-4 inhibitor 3

Cat.No: T61414

Carmegliptin dihydrochloride

Cat.No: T68652

Cat.No: T38771

Synonym: P32/98

DPP IV/hCA II-IN-1

Cat.No: T74978

Cat.No: T68491

NVP DPP 728 dihydrochloride

Cat.No: T21691

DPP-4/GPR119 modulator 1

Cat.No: T74528

Fotagliptin benzoate

Cat.No: T73875

Cat.No: T37861

Teduglutide TFA

Cat.No: T81025

Synonym: ALX-0600 TFA

Cat. No.	Product Name	Target	Signaling Pathways
TN1418	Azaleatin 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮	DPP-4	Proteases/Proteasome
	Azaleatin 是分离自Rhododendron 种中的 O-甲基化黄酮醇。它是二肽基肽酶-IV 的抑制剂。它在 2 型糖尿病和肥胖症中有研究的价值。
T16838	Saikogenin A	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saikogenin A 是一种二肽基肽酶 IV 抑制剂，可从中药柴胡中提取。
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
T81898	Lyciumamide A
	DPP-IV-IN-5，一种从枸杞果实中分离得到的化合物，对过氧化物酶体增殖物激活受体(PPARγ)展示中等拮抗活性，其EC50值介于10.09至44.26 μM，同时对二肽基肽酶-4 (DPPIV)亦有抑制作用，IC50值为47.13 μM。

天然产物

Cat.No: TN1418

Synonym: 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮

Target: DPP-4

Cat.No: T16838

Target: Proteasome, DPP-4

Cat.No: T39219

Cat.No: T81898

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