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Cat. No. | Product Name | Target | Signaling Pathways |
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T11539 |
HCV-IN-29
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HCV-IN-29 是一种丙型肝炎病毒抑制剂。 | |||
T8139 |
Sulfamethoxazole sodium
新诺明钠,Ro 4-2130 sodium,磺胺甲恶唑钠 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfamethoxazole sodium (Ro 4-2130 sodium) 是一种磺胺类抗菌素。它常用于各种尿道病原体的研究,与 Trimethoprim 联用,可用于尿路感染的研究。 | |||
T1283 |
Clinafloxacin
克林沙星,PD 127391,CI-960,AM-1091 |
Antibacterial; Antibiotic | Microbiology/Virology |
Clinafloxacin (CI-960) 是一种高效广谱氟喹诺酮类抗生素,抑制革兰氏阳性、革兰氏阴性和厌氧病原体。它对金黄色葡萄球菌的 DNA 促旋酶和拓扑异构酶 IV 有抑制作用,IC50值分别为 0.92 µg/ml 和 1.62 µg/ml。 | |||
T20058 |
Prothioconazole
HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893 |
Antifungal | Microbiology/Virology |
Prothioconazole (Proline 480 SC Fungicide) 是一种手性三唑类杀菌剂,用于植物病原控制。 | |||
T37746 |
N-phenylacetyl-L-Homoserine lactone
|
Others | Others |
N-phenylacetyl-L-Homoserine lactone 可衰减病原体鲍曼不动杆菌的群体感应,可用于研究细菌感染。 | |||
T13667L1 |
Dusquetide aceate
Dusquetide aceate (931395-42-5 Free base) |
Antibacterial | Microbiology/Virology |
Dusquetide aceate 是一种针对损伤相关分子模式和病原体相关分子模式的先天免疫防御调节剂。 Dusquetide aceate 具有抗炎和抗菌活性。 | |||
T9000 |
Pyrimorph
|
Antifungal | Microbiology/Virology |
Pyrimorph 是一种杀真菌剂,对 oomycetes 具有良好抑菌活性。 | |||
T23133 |
Pentamidine
|
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology |
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。 | |||
T8886 |
NITD-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂,可抑制 DENV RdRp 介导的 RNA 延伸。 | |||
T8591 |
RNase L-IN-2
5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one |
Others | Others |
RNase L-IN-2 是 RNase L 的激活剂,EC50 为 22 uM;对多种类型的 RNA 病毒(包括人类病原体人类副流感病毒 3 型)具有广谱抗病毒活性,在有效浓度下没有细胞毒性。 | |||
T10222 |
ABMA
|
Parasite | Microbiology/Virology |
ABMA是一种广谱抑制剂,面向细胞内毒素和病原体。通过选择性作用于宿主细胞的晚期内体,而非直接针对毒素或病原体本身,ABMA有效地保护细胞免遭病毒、细胞内细菌及寄生虫等多种病原体的侵害,展现出广谱的抗感染活性。 | |||
T34092 |
Pneumocysterol
|
||
Pneumocysterol is a sterol detected in the opportunistic pathogen Pneumocystis carinii hominis. | |||
T25174 |
Brassilexin
Brassilexine |
||
Brassilexin is a cyclobrassinin hydrolase inhibitor, a unique enzyme from the fungal pathogen Alternaria brassicicola. | |||
T12991 | SPR206 | Others | Others |
SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen. | |||
T32537 |
LAI-1
LAI 1,Legionella autoinducer-1,Legionella autoinducer 1 |
||
LAI-1 is a regulator of bacterial signaling, modulating gene regulation and cellular responses of eukaryotic cells (amoebae or macrophages) and a variety of processes including pathogen-host cell interactions. | |||
T25256 |
Pitstop1
Clathrin inhibitor 1,Clathrin-inhibitor-1,Clathrin IN 1 |
||
Clathrin-IN-1 is a selective clathrin inhibitor that acts by addressing clathrin function in cell physiology with potential applications as an inhibitor of virus and pathogen entry and as a modulator of cell signaling. | |||
T61234 |
Stemphyperylenol
|
||
Stemphyperylenol exhibits potent antifungal activity against Alternaria solani, a plant pathogen, with a minimum inhibitory concentration (MIC) value of 1.57 μM. | |||
T61437 |
HPK1-IN-26
|
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HPK1-IN-26, a novel compound, is a potent inhibitor of both HPK1 and GLK. This small molecule exhibits promise in aiding the study of animal pathogen infection [1]. | |||
T28161 |
NEU-1045
NEU 1045,NEU1045 |
||
NEU-1045 is a T. brucei proliferation inhibitor, and is a promising lead with cross-pathogen activity. NEU-1045 inhibited T. brucei, T. cruzi, and L. major proliferation with good potency (T. brucei EC50 = 0.37 μM; T. cruzi EC50 = 2.8 μM; L. major EC50 = | |||
T36401 | DCVC | ||
DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p... | |||
T61067 | MurB-IN-1 | ||
MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of bacterial cell wall. With a binding affinity of K d 3.57 μM, MurB-IN-1 effectively hinders the activity of MurB, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1]. | |||
T35774 |
HC Toxin
|
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HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. | |||
T37337 |
N-3-oxo-hexadecanoyl-L-Homoserine lactone
|
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N-3-oxo-hexadecanoyl-L-Homoserine lactone is an unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria, including strains of Agrobacterium vitis and Pseudomonas. Like other AHLs, this C16-containing form is thought to be involved in quorum sensing. Substituted, long-chain AHLs, including N-3-oxo-tetradecanoyl-L-homoserine lactone , prime for systemic acquired resistance to pathogen attack in plants. | |||
T39548 |
Amustaline dihydrochloride
S-303 dihydrochloride |
||
Amustaline (S-303) dihydrochloride is a nucleic acid-targeted alkylator recognized for its efficacy as a pathogen inactivation agent in blood components containing red blood cells. This compound comprises three key elements: an acridine anchor (a non-covalently bonding intercalator targeting nucleic acids), an effector (a bis-alkylator group that interacts with nucleophiles), and a linker (a flexible carbon chain with a labile ester bond, hydrolyzing at neutral pH to non-reactive products). | |||
T76040 | Dusquetide TFA | ||
Dusquetide (SGX942) TFA 是一类天然防御调节因子(IDR)。Dusquetide TFA 通过与 p62 结合调节 PAMPs 和 DAMPs 的天然免疫应答。Dusquetide TFA 在减轻炎症和增加细菌感染清除方面都显示出活性。 | |||
T71325 |
ANA-773
|
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ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which... | |||
T37283 |
1-Palmitoyl Lysophosphatidic Acid (sodium salt)
|
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1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, pipe... | |||
T60286 | DHFR-IN-2 | ||
DHFR-IN-2 (化合物 4e) 是一种有效且非竞争性的MtDHFR 抑制剂,其IC50值为 7 μM。来自结核分枝杆菌 (MtDHFR) 的二氢叶酸还原酶具有很高的未开发潜力,可以成为抗结核病 (TB) 新药的靶标,因为它对病原体存活很重要。DHFR-IN-2可用于结核病(TB)研究。 | |||
T80090 |
Lugdunin
|
Antibiotic | Microbiology/Virology |
Lugdunin是一种具有抗菌活性的肽类抗生素。该化合物能够通过破坏细菌细胞膜的电位来抑制革兰氏阳性菌的生长,特别是对金黄色葡萄球菌(Staphylococcus aureus)表现出高效能,有效降低其在皮肤和鼻腔的定植能力。此外,Lugdunin还能在人类角质形成细胞和小鼠皮肤中促进LL-37和CXCL8/MIP-2的表达。 | |||
T79757 |
Meliadubin B
|
NO Synthase | Immunology/Inflammation |
Meliadubin B是一种具有显著生物活性的天然三萜类化合物。它能有效抑制人中性粒细胞中超氧阴离子的产生,具有炎症抑制作用(EC50为5.54 μM)。同时,Meliadubin B也能抑制诱导型一氧化氮合酶的活性。此外,该化合物还能对抗水稻病原真菌Magnaporthe oryzae,显示出显着的抑制效果,其IC50为182.50 μM。 | |||
T37394 |
13(S)-HpOTrE
|
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13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.1 In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.[2],[3],[4] Treatment of to... | |||
T41240 |
Verrucarin A
|
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Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂,来源于Myrothecium verrucaria,可抑制白血病细胞系生长,并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T9599 |
3,4,5-Trimethoxybenzaldehyde
|
Anti-infection; Antibacterial | Microbiology/Virology |
3,4,5-Trimethoxybenzaldehyde 是合成各种药物,特别是治疗细菌感染的甲氧苄啶的中间体,它有抗念珠菌功效并抑制粘附和生物膜。 | |||
T19458 |
N-Hydroxypipecolic acid
1-Hydroxy-2-piperidinecarboxylic acid,NHP |
Others | Others |
N-Hydroxypipecolic acid (NHP) 是植物代谢产物和系统性获得性抗性调节剂,可与免疫信号水杨酸协调建立系统性获得性抗性,诱导系统获得性耐药对细菌和卵菌感染。它在植物叶片中系统地积累,以应对病原菌的侵袭。 | |||
TN2943 |
3-Hydroxy-6-methoxyflavone
|
Others | Others |
3-Hydroxy-6-methoxyflavone 可与抗生素联合用药来治疗 ESKAPE 病原体感染。 | |||
T6S0270 |
Ononin
Formononetin 7-O-β-D-glucopyranoside,Formononetin glucoside,Ononoside,芒柄花苷,Formononetin 7-O-glucoside |
Antibacterial | Microbiology/Virology |
Ononin (Formononetin 7-O-glucoside) 是一种能够抑制土壤中杂 Pluchea lanceolata 生长的异黄酮。 | |||
T21771 |
Pyoluteorin
|
Antibiotic | Microbiology/Virology |
Pyoluteorin 是一种抗生素 (antibiotic),可抑制 Oomycete fungi,包括植物病原体 Oomycete fungi,并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。 | |||
T13605 |
Cercosporin
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelength. Cercosporin contains the perylene quinone structural features necessary for PKC activity (I | |||
TN4579 |
Monomethylsulochrin
|
Antifection | Microbiology/Virology |
Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM. | |||
TN3450 |
Artanin
|
Antifection | Microbiology/Virology |
Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml. | |||
TN4748 | Penduletin | VEGFR; COX; Prostaglandin Receptor; Antifection | Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Tyrosine Kinase/Adaptors |
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity. | |||
T75454 | Penicitide A | ||
Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae 和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。 | |||
T83904 |
Polymyxin E2 sulfate
Colistin B sulfate |
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Polymyxin E2 是一种肽类抗生素,也是最初从B. polymyxa分离出的阳离子脂肽抗生素colistin的主要成分。该化合物对植物致病菌X. oryzae具有活性(EC50 = 0.21 µg/ml),并且在温室研究中,当以200 µg/ml的浓度应用时,能够预防和逆转水稻细菌性叶枯病。 |