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5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12189 |
NBDHEX
|
Apoptosis; Glutathione Peroxidase; Autophagy | Apoptosis; Autophagy; Metabolism |
NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂,也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡,通过抑制 GST 的催化活性,避免抑制剂被特异性泵从细胞中排出,以及破坏 GSTP1-1和关键信号传导因子之间的相互作用,从而起到抗癌的作用。 | |||
T71058 |
Doramapimod HCl
|
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Doramapimod HCl is the salt form of Doramapimod, a member of the N-pyrazole-N'-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB -796 has entered clinical trials for the treatment of autoimmune diseases. | |||
T11048 |
DIPQUO
|
Others | Others |
DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. The EC50 in C2C12 cells was 6.27 μM. | |||
T23617 |
Aclacinomycin
Aclacinomycins,Siwenmycin |
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Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S2382 |
3'-Hydroxypterostilbene
3’-羟基紫檀茋,3'-羟基紫檀茋,3'-HPT |
Apoptosis; Autophagy | Apoptosis; Autophagy |
3'-Hydroxypterostilbene (3'-HPT) 是天然紫檀芪类似物,通过诱导细胞凋亡和自噬,有效抑制人结肠癌细胞的生长。它抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK 途径。 | |||
T4S2063 |
Tetrahydrocoptisine
人血草碱,STYLOPINE |
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,这可能涉及抑制肺部炎症过程。它具有胃保护活性,归因于减少 NO 产生和调节促炎细胞因子,抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分,通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。 | |||
T2836 |
Isorhamnetin
3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin |
MEK; PI3K; Endogenous Metabolite | MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。 | |||
T23774 |
Bauerenol
NSC 147745,Baurenol |
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Bauerenol is a triterpenoid from Indian Suregada angustifolia. It also induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma cells. | |||
TN1211 |
2-Hydroxy-3-methylanthraquinone
|
ERK; p38 MAPK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction. |