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17

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1855	ZCL278 ZCL 278	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	ZCL278 是一种选择性 Cdc42 GTPase 抑制剂，与Cdc42结合，Kd 为 11.4 μM。
T1482	Ciclopirox 环吡酮,HOE296b,环吡酮胺	ATPase; Ferroptosis; Antibacterial; Autophagy; Antifungal	Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Ciclopirox (HOE296b) 是一种合成的抗真菌剂，可研究浅表真菌病。
T25529	IMM-01	GTPase	GPCR/G Protein
	IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。
T32587	Latrunculin M
	Latrunculin M, a novel marine toxin, disrupts microfilament organization in cultured cells.
T69436	Endosidin7
	Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis without affectting endomembrane trafficking during interphase or cytoskeletal organization.
T30460	BIR2 Balloon inducing reagent 2,BIR-2,BIR 2,Balloon inducing reagent-2
	BIR2 is a balloon inducing reagent, which triggers a spontaneous self-organization process, leading to the formation of 3-D balloon like structure during hESC differentiation.
T32588	Latrunculins A
	Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.
T30459	BIR1 Balloon inducing reagent-1,Balloon inducing reagent 1
	BIR1 is a balloon inducing reagent, which triggers a spontaneous self-organization process, leading to the formation of 3-D balloon like structure during hESC differentiation.
T35820	CAY10685
	CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.
T69623	Tridemorph
	Tridemorph is a sterol biosynthetic inhibitor. It is a fungicide used to control Erysiphe graminis. It was developed by BASF in the 1960s who use the trade name Calixin. The World Health Organization has categorized it as a Class II moderately hazardous" pesticide because it is believed harmful if swallowed and can cause irritation to skin and eyes."
T69429	Y27632 HCl hydrate
	Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord...
T80287	KLTWQELYQLKYKGI	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	KLTWQELYQLKYKGI (QK) 是一种与VEGF受体结合并同VEGF竞争的VEGF模拟肽。在口服或全身给药时，该化合物对啮齿类动物胃溃疡的愈合展现了活性。此外，KLTWQELYQLKYKGI 在体外具有诱导毛细血管形成和组织的能力。
T38336	W140 (trifluoroacetate salt) W140 (trifluoroacetate salt)
	Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W...
T62040	Tubulin polymerization-IN-30
	Tubulin polymerization-IN-30 (compound 6e) 是有效的微管蛋白聚合 (Tubulin polymerization) 抑制剂，可破坏细胞内微管组织，将细胞周期阻滞在 G2/M 期。Tubulin polymerization-IN-30 对 HeLa、SGC-7901和A549 等肿瘤细胞系具有良好的抗肿瘤活性，其IC50分别为 0.403、 2.16和2.21 μM。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin
T38218	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂，在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症（ALS）模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T37063	Laulimalide
	Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety fo...

化合物

Cat.No: T1855

Synonym: ZCL 278

Target: CDK, Ras

Cat.No: T1482

Synonym: 环吡酮,HOE296b,环吡酮胺

Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal

Cat.No: T25529

Target: GTPase

Cat.No: T32587

Cat.No: T69436

Cat.No: T30460

Synonym: Balloon inducing reagent 2,BIR-2,BIR 2,Balloon inducing reagent-2

Cat.No: T32588

Cat.No: T30459

Synonym: Balloon inducing reagent-1,Balloon inducing reagent 1

Cat.No: T35820

Cat.No: T69623

Y27632 HCl hydrate

Cat.No: T69429

KLTWQELYQLKYKGI

Cat.No: T80287

Target: VEGFR

W140 (trifluoroacetate salt)

Cat.No: T38336

Synonym: W140 (trifluoroacetate salt)

Tubulin polymerization-IN-30

Cat.No: T62040

Cat.No: TP2182

Target: Others

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

Cat.No: T38218

Cat.No: T37063

Cat. No.	Product Name	Target	Signaling Pathways
T16075	(Rac)-Idroxioleic acid 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval	Apoptosis	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种具有抗肿瘤作用的脂肪酸酰胺水解酶抑制剂。它与质膜结合并改变脂质组织。

天然产物

(Rac)-Idroxioleic acid

Cat.No: T16075

Synonym: 2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval

Target: Apoptosis

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