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Search Results for " neuromuscular "

62

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13491	Neuromuscular-targeting compound 1	Others	Others
	Neuromuscular-targeting compound 1 可用于研究肌肉萎缩和神经肌肉相关疾病。
T10059	Neuromuscular Disorder-Targeting Compound 1	Others	Others
	Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and fibromyalgia syndrome.
T0166	Pancuronium dibromide Pancuronium bromide,Pavulon,泮库溴铵	AChR	Neuroscience
	Pancuronium dibromide (Pavulon) 是一种双季基类固醇，是一种神经肌肉松弛剂。它通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。它还可抑制心脏毒蕈碱受体并具有拟交感神经作用。
T1234	5,5-Dimethyloxazolidine-2,4-dione Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) 是抗惊厥药，是 TRIMETHADIONE 的活性代谢物。
T5326	Sugammadex sodium Org25969,Sugammadex (sodium),舒更葡糖钠	Others	Others
	Sugammadex sodium (Org25969) 是合成的 γ 环糊精衍生物，是一种新型的神经肌肉阻断逆转剂。
T21793	CGP 35348	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T2227	Hemicholinium 3 半胆碱基-3,Hemicholinium-3,Hemicholine	Others; AChE	Neuroscience; Others
	Hemicholinium 3 是一种竞争性的、高亲和力的胆碱转运蛋白 (HACU) 抑制剂，Ki=25 nM。它是一种神经肌肉阻滞剂，能够抑制乙酰胆碱 (ACh)的合成和释放。它抑制Epibatidine 诱发的收缩和 [3H] 乙酰胆碱释放，IC50分别为 897 nM 和 693 nM。
T6397	Atracurium besylate Tracrium,51W89,BW-33A,苯磺酸阿曲库铵	AChR	Neuroscience
	Atracurium besylate (51W89) 是一种神经肌肉阻断剂，ED95为0.2 mg/kg。
T22371	Mivacurium dichloride 米库氯铵,Mivacurium chloride,二氯美维库铵	AChR	Neuroscience
	Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物，可与 nAChR 偶联，以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T6684	Succinylcholine Chloride Dihydrate choline chloride succinate,Succinyldicholine dichloride,Suxamethonium Chloride Dihydrate,司可林	AChR	Neuroscience
	Succinylcholine Chloride Dihydrate (Succinyldicholine dichloride) 是一种烟碱型 AChR 激动剂，也可作为去极化神经肌肉阻滞剂。
T3966	Tirasemtiv CK-2017357,泰拉生替	Others	Others
	Tirasemtiv (CK-2017357) 是一种快速骨骼肌型肌钙蛋白复合物激活剂。
T0818	Decamethonium bromide 十烃溴铵,Decacuran,溴化十烃季胺,Syncurine	AChR; AChE	Neuroscience
	Decamethonium bromide (Syncurine) 是神经肌肉阻滞剂和烟碱型 AChR 部分激动剂。
T77445	Apitegromab SRK-015	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Apitegromab (SRK-015) 是一种新型肌肉生长抑制素抑制剂，是一种靶向肌肉生长抑制素前体的抗体,可用于研究脊髓性肌萎缩症在内的神经肌肉疾病。
TP1868	Proctolin 直肠肽	Others	Others
	Proctolin 是内源性五肽，也是兴奋性神经调节剂。
T1259	Pyrantel pamoate 双羟萘酸噻嘧啶,Pyrantel embonate	Others; Antibiotic; Parasite	Microbiology/Virology; Others
	Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。
T12481	Pipecuronium bromide RGH-1106	AChR	Neuroscience
	Pipecuronium bromide (RGH-1106)是一种具有选择性和有效性的 nAChR 拮抗剂，也可当作一种非去极化甾体神经肌肉阻滞剂，可使肌肉松弛，常与抗生素一起使用。
TP1253	Argireline 六胜肽,Acetyl hexapeptide-3,阿基瑞林	Others	Others
	Argireline (Acetyl hexapeptide-3) 是可渗透皮肤的、无毒的抗皱肽。它对神经肌肉接头处依赖 Ca2+的神经递质释放具有显著的抑制作用。它具有抗皱和抗衰老的活性。
T20344	Acetylcholine bromide	Others	Others
	Acetylcholine bromide 是乙酰胆碱的溴化物盐。它是一种神经递质，存在于神经肌肉接头、自主神经节、副交感神经效应器接头、交感神经效应器接头的一个子集以及中枢神经系统的许多部位。
T1594	Vecuronium bromide ORG NC 45,维库溴铵	AChR	Neuroscience
	Vecuronium bromide (ORG NC 45) 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂，具有肌肉松弛活性。
T14094	Acetamiprid	AChR	Neuroscience
	Acetamiprid 是广泛使用的新烟碱类杀虫剂，是一种烟碱型乙酰胆碱受体激动剂，与神经肌肉和生殖系统疾病有关。
T0156	Rocuronium bromide ORG 9426,罗库溴铵,ORG 9426 (Bromide)	AChR	Neuroscience
	Rocuronium bromide (ORG 9426) 是一种氨基甾体类的、非去极化的神经肌肉受体抑制剂，也是一种肌肉松弛剂。
T0077	Dantrolene sodium Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Dantrolene sodium (Lapatinib ditosylate monohydrate) salt 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。
T23960	Dacuronium UNII-VD6L56ZVX1,17-Hydroxypancuronium,Androstane, piperidinium deriv
	Dacuronium is a new steroidal drug of neuromuscular blocking properties. Dacuronium produced a competitive type of neuromuscular block with a potency of approximately one-tenth that of tubocurarine and one-fiftieth that of pancuronium.
T26672	Astromicin Sulfate A-44747,A 44747,A44747
	Astromicin Sulfate is an antibiotic with aminoglycoside structure. Astromicin Sulfate may produce depression of neuromuscular function.
T0818L	Decamethonium
	Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis.
T31296	Decamethonium chloride Decamethylenebis(trimethylammonium chloride),Decamethonium dichloride
	Decamethonium is a depolarizing muscle relaxant or neuromuscular blocking agent,[1] and is used in anesthesia to induce paralysis.
T30079	ANQ-9040
	ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.
T25636	Laudexium Laudexium ion,Laudexium cation
	Laudexium is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle re
T24057	Fazadinium bromide
	Fazadinium bromide is a muscle relaxant. It acts as a nicotinic acetylcholine receptor antagonist through the neuromuscular blockade.
T69425	Metocurine chloride
	Metocurine is a muscle relaxant through neuromuscular blockade. It is excreted entirely through the kidneys and therefore should not be used in patients with kidney failure.
T33721	Norcoralydine S-(-)-Xylopinine,l-Xylopinine,NSC 23898,NSC-23898,NSC23898
	Norcoralydine is a neuromuscular blocking agent.
T12748	Rocuronium 罗库铵,Org-9426	Others	Others
	Rocuronium is an blocker of aminosteroid non-depolarizing neuromuscular.
T13908	SZ1676	Others	Others
	SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.
T0395L	Pyrantel Strongid,Pyrantelum,Pyrequan,Pin-X,Pirantele
	Pyrantel is a nicotinic receptor agonist and a depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes.
TP2218	α-Conotoxin EI	Others	Others
	Selective antagonist of neuromuscular nicotinic receptors α1β1γδ
T32066	Hexafluronium Bromide Mylaxen,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro
	Hexafluronium bromide is a neuromuscular blocker and nicotinic acetylcholine receptor antagonist used in anesthesiology to prolong and enhance the skeletal muscle relaxation of succinylcholine during surgery.
T21099	Decamethonium iodide Decamethonium iodatum,Decamethonium diiodide,Dekamethoniumjodid
	Decamethonium is a neuromuscular blocking agent or depolarizing muscle relaxant, and is used in anesthesia to induce paralysis.
T25683	Leucomyosuppressin p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2
	Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction.
T23961	Dacuronium bromide NB 68,ORG 6368,NB68,Dacuronii bromidum
	Dacuronium bromide is an aminosteroid neuromuscular blocking agent Pancuronium. It acts as a competitive antagonist of the nicotinic acetylcholine receptor.
T32870	Lophotoxin
	Lophotoxin belongs to the cembrene class of diterpenoids; neuromuscular toxin isolated from several pacific gorgonians of the genus Lophogorgia.
T16814	RX 67668	Others	Others
	RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue. RX 67668 is an effective cholinesterase inhibitor (IC50: 5 μM for both acetylcholinesterase and butyrylcholinesterase). RX 67668 can reverse the neuromuscular blockade induced by D-tub
T26230	Stilbamidine dihydrochloride NSC 35605,NCI 174
	Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.
TP2077	α-Bungarotoxin
	Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM
TP2407	Small cardioactive peptide A SCPA
	Small cardioactive peptide A, as a neuropeptide that modulates neuromuscular synapsis in Aplysia, can also function as a neural cotransmitter in molluscs and exert a role in both the central and peripheral modulation of the control of feeding behavior.
T25637	Laudexium methylsulfate Laudexium,Laudolissin methosulphate
	Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
T68783	Stercuronium
	Stercuronium is an aminosteroid neuromuscular blocking agent which was never marketed. It acts as a competitive antagonist of the nicotinic acetylcholine receptor, and is also reported to be an acetylcholinesterase inhibitor.
T37702	Pancuronium (bromide hydrate)
	Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC50value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.1It acts as a non-depolarizing neuromuscular blocking agent.2Pancuronium enhances anesthesia induced by isoflurane , reducing immobilization with an ED50value of 1.62 μg/kg.3 1.Liu, M., and Dilger, J.P.Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholin...
T75283	Atracurium
	Atracurium (BW-33A free acid)为高效的竞争性非去极化神经肌肉阻滞剂，兼具AChR受体拮抗作用。该化合物能够诱导支气管收缩及实现神经肌肉阻滞，并促进星形胶质细胞分化[5]。
T74690	Monarsen
	Monarsen (EN101) 是一种针对人 AChE 基因的反义寡核苷酸。Monarsen 被用于自身免疫性重症肌无力 (MG)的研究，这是一种由针对乙酰胆碱受体 (AChR) 的自身抗体引起的神经肌肉疾病。

化合物

Neuromuscular-targeting compound 1

Cat.No: T13491

Target: Others

Neuromuscular Disorder-Targeting Compound 1

Cat.No: T10059

Target: Others

Pancuronium dibromide

Cat.No: T0166

Synonym: Pancuronium bromide,Pavulon,泮库溴铵

Target: AChR

5,5-Dimethyloxazolidine-2,4-dione

Cat.No: T1234

Synonym: Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione

Target: Calcium Channel

Sugammadex sodium

Cat.No: T5326

Synonym: Org25969,Sugammadex (sodium),舒更葡糖钠

Target: Others

Cat.No: T21793

Target: GABA Receptor

Hemicholinium 3

Cat.No: T2227

Synonym: 半胆碱基-3,Hemicholinium-3,Hemicholine

Target: Others, AChE

Atracurium besylate

Cat.No: T6397

Synonym: Tracrium,51W89,BW-33A,苯磺酸阿曲库铵

Target: AChR

Mivacurium dichloride

Cat.No: T22371

Synonym: 米库氯铵,Mivacurium chloride,二氯美维库铵

Target: AChR

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Succinylcholine Chloride Dihydrate

Cat.No: T6684

Synonym: choline chloride succinate,Succinyldicholine dichloride,Suxamethonium Chloride Dihydrate,司可林

Target: AChR

Cat.No: T3966

Synonym: CK-2017357,泰拉生替

Target: Others

Decamethonium bromide

Cat.No: T0818

Synonym: 十烃溴铵,Decacuran,溴化十烃季胺,Syncurine

Target: AChR, AChE

Cat.No: T77445

Synonym: SRK-015

Target: Opioid Receptor

Cat.No: TP1868

Synonym: 直肠肽

Target: Others

Pyrantel pamoate

Cat.No: T1259

Synonym: 双羟萘酸噻嘧啶,Pyrantel embonate

Target: Others, Antibiotic, Parasite

Pipecuronium bromide

Cat.No: T12481

Synonym: RGH-1106

Target: AChR

Cat.No: TP1253

Synonym: 六胜肽,Acetyl hexapeptide-3,阿基瑞林

Target: Others

Acetylcholine bromide

Cat.No: T20344

Target: Others

Vecuronium bromide

Cat.No: T1594

Synonym: ORG NC 45,维库溴铵

Target: AChR

Cat.No: T14094

Target: AChR

Rocuronium bromide

Cat.No: T0156

Synonym: ORG 9426,罗库溴铵,ORG 9426 (Bromide)

Target: AChR

Dantrolene sodium

Cat.No: T0077

Synonym: Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt

Target: Others, Calcium Channel

Cat.No: T23960

Synonym: UNII-VD6L56ZVX1,17-Hydroxypancuronium,Androstane, piperidinium deriv

Astromicin Sulfate

Cat.No: T26672

Synonym: A-44747,A 44747,A44747

Cat.No: T0818L

Decamethonium chloride

Cat.No: T31296

Synonym: Decamethylenebis(trimethylammonium chloride),Decamethonium dichloride

Cat.No: T30079

Cat.No: T25636

Synonym: Laudexium ion,Laudexium cation

Fazadinium bromide

Cat.No: T24057

Metocurine chloride

Cat.No: T69425

Cat.No: T33721

Synonym: S-(-)-Xylopinine,l-Xylopinine,NSC 23898,NSC-23898,NSC23898

Cat.No: T12748

Synonym: 罗库铵,Org-9426

Target: Others

Cat.No: T13908

Target: Others

Cat.No: T0395L

Synonym: Strongid,Pyrantelum,Pyrequan,Pin-X,Pirantele

α-Conotoxin EI

Cat.No: TP2218

Target: Others

Hexafluronium Bromide

Cat.No: T32066

Synonym: Mylaxen,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro

Decamethonium iodide

Cat.No: T21099

Synonym: Decamethonium iodatum,Decamethonium diiodide,Dekamethoniumjodid

Leucomyosuppressin

Cat.No: T25683

Synonym: p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2

Dacuronium bromide

Cat.No: T23961

Synonym: NB 68,ORG 6368,NB68,Dacuronii bromidum

Cat.No: T32870

Cat.No: T16814

Target: Others

Stilbamidine dihydrochloride

Cat.No: T26230

Synonym: NSC 35605,NCI 174

α-Bungarotoxin

Cat.No: TP2077

Small cardioactive peptide A

Cat.No: TP2407

Synonym: SCPA

Laudexium methylsulfate

Cat.No: T25637

Synonym: Laudexium,Laudolissin methosulphate

Cat.No: T68783

Pancuronium (bromide hydrate)

Cat.No: T37702

Cat.No: T75283

Cat.No: T74690

Cat. No.	Product Name	Target	Signaling Pathways
T6S0084	Tuberostemonine 对叶百部碱,Tuberstemonine	Parasite	Microbiology/Virology
	Tuberostemonine (Tuberstemonine) 是一种生物碱，可作为抗疟疾剂，有较高的肠道通透性。
T6751	Acetylcholine iodide Acetylcolina	Others	Others
	Acetylcholine iodide (Acetylcolina) 是一种在中枢和外周神经系统中常见的神经递质。
T4S1876	3-Deoxyaconitine	Sodium Channel	Membrane transporter/Ion channel
	3-Deoxyaconitine 是一种二萜类生物碱，对钠离子通道有激活作用。
TN2034	Paeoniflorigenone	Others; Caspase	Apoptosis; Others; Proteases/Proteasome
	Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine.
T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

Tuberostemonine

Cat.No: T6S0084

Synonym: 对叶百部碱,Tuberstemonine

Target: Parasite

Acetylcholine iodide

Cat.No: T6751

Synonym: Acetylcolina

Target: Others

3-Deoxyaconitine

Cat.No: T4S1876

Target: Sodium Channel

Paeoniflorigenone

Cat.No: TN2034

Target: Others, Caspase

Cat.No: T36068

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