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Search Results for " mu-opioid "

38

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7748	Dermorphin TFA 皮啡肽三氟乙酸盐	Others; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others
	Dermorphin TFA 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。
T62767	Mu opioid receptor antagonist 3
	Mu opioid receptor antagonist 3 (compound 26) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.24 nM, EC50: 0.54 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性，诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。
T7404	Dermorphin 皮啡肽	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Dermorphin 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。
T62673	Mu opioid receptor antagonist 5
	Mu opioid receptor antagonist 5 (compound NAP) 是一种选择性的、能够透过血脑屏障的 μ 阿片受体 (MOR) 拮抗剂 (EC50: 1.14 nM, Ki: 0.37 nM)。Mu opioid receptor antagonist 5 能够用于研究阿片类药物使用障碍 (OUD)。
T62766	Mu opioid receptor antagonist 2
	Mu opioid receptor antagonist 2 (compound 25) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.37 nM, EC50: 0.44 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性，诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。
T62768	Mu opioid receptor antagonist 4
	Mu opioid receptor antagonist 4 (compound 31) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.38 nM, EC50: 0.38 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性，诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。
T79431	Mu opioid receptor antagonist 7	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Muopioid receptorantagonist 7 (compound 24) 是一种有效的CNS渗透性μOR (μ-阿片受体)拮抗剂，具有29 ± 3.0 nM的IC50。该化合物可用于研究疼痛和阿片类药物使用障碍。
T1242	Alvimopan 爱维莫潘	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂，IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中，可用于术后肠梗阻的研究。
T27667	JNJ-20788560 JNJ 20788560	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	JNJ-20788560 是一种δ阿片受体（DOR）激动剂，具有镇痛活性。它对 DOR 的选择性高于μ阿片受体（MOR）。
T1197	Trimebutine maleate Debridat,Polibutin,马来酸曲美布汀	Calcium Channel; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Trimebutine maleate (Polibutin) 是一种外周 μ、δ 和 kappa 阿片受体激动剂，用作治疗慢性和急性腹痛的解痉药物。
T31081	CP-866087 CP 866087,UNII-MDH21334PI,CP-866,087,CP866087	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	CP-866087 是一种新型、有效和选择性的μ阿片受体拮抗剂，用于研究女性性功能障碍。
T4407	SR17018	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	SR17018 是一种 μ-阿片受体 (MOR) 激动剂，与 GTPγS 结合，EC50 为 97 nM。
T50091	1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride 1-(8-carbamimidamidooctyl)guanidine dihydrochloride	Others	Others
	1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride 是一种合成的阿片肽，来源于天然阿片肽脑啡肽。它是μ-阿片受体（MOR）的高效激动剂，Ki 为0.14 nM，是一种有效的MOR 激动剂。
T39529	AT-121 hydrochloride	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	AT-121 hydrochloride 是一种 nociception 和 mu 阿片受体 (mu opioid receptor)的双重激动剂，Ki 值分别为 3.67 和 16.49 nM。AT-121 hydrochloride 是一种安全、无成瘾性且科缓解疼痛的化合物，具有抗伤害和止痛活性。
T10593	BPR1M97	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BPR1M97 是一种具有血脑屏障渗透性和有效性的 mu 阿片受体（MOP）和神经肽-啡肽 FQ（NOP）受体激动剂，对 MOP 的 Kis 值为1.8 nM，对 NOP 的Kis 值为 4.2 nM。BPR1M97 具有抗伤害作用和抗痛觉作用。
T7211	Tyr-Gly-Gly-Phe-Met-OH Methionine enkephalin,蛋氨酸脑啡肽,Met-Enkephalin,[MET5]脑啡肽	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) 是天然存在的内源性阿片肽、metenkephalin 和 zeta-和 delta-阿片受体激动剂的合成形式，是 mu-阿片受体激动剂，具有潜在的镇痛、神经调节、免疫调节、抗炎、抗肿瘤作用以及镇痛、抗抑郁和胃肠运动调节活性。
T0918	Trimebutine 曲美布汀,Mebutin	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Trimebutine (Mebutin) 是阿片受体激动剂，有抗毒蕈碱活性。它是解痉剂，可调节肠道和结肠运动，并通过抗毒蕈碱和弱μ-阿片受体激动剂作用缓解腹痛。
T7306	Valorphin Valorphin TFAsalt	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Valorphin (Valorphin TFAsalt) 是内源性血红蛋白 β 链第 33-39 位氨基酸残基，具有阿片类镇痛活性，与大鼠 mu-阿片受体结合，IC50 为 14 nM。它有抗肿瘤活性，也可用于缓解疼痛的研究。
T25194	BW 443C BW443C,BW-443C,Tyr-arg-gly-(4-nitro-phe)-pro-NH2
	BW 443C is a selective agonist of mu-opioid receptor.
T71189	RX 809055AX
	RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.
T26918	BU08028 BU 08028,BU-08028
	BU08028 is a mu opioid peptide (MOP) receptor and nociceptin-orphanin FQ peptide (NOP) receptor agonist.
T70730	Oxycodegol phosphate
	Oxycodegol phosphate is a mu-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain
T1242L	Alvimopan monohydrate
	Alvimopan monohydrate is a mu-opioid receptor antagonist that intended for the treatment of constipation in patients who take opiates for pain.
T69121	Oxpheneridine
	Oxpheneridine is a mu opioid receptor agonist that possesses the spasmolytic activity and acts as a narcotic analgesic.
T10926L	CYT-1010 hydrochloride	Others	Others
	CYT-1010 hydrochloride is an mu-opioid receptor agonist. The EC50 for β-arrestin recruitment and cAMP production inhibition were 13.1 nM and 0.0053 nM, respectively.
T60415	DS34942424
	DS34942424 是一种没有μ 阿片受体激动剂活性的口服强效镇痛剂。
T71225	Oxicodegol HCl
	Oxicodegol HCl is a mu-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain
T71224	Oxicodegol trifluoroacetate
	Oxicodegol trifluoroacetate is a mu-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain
T10926	CYT-1010	Others	Others
	CYT-1010 is an mu-opioid receptor agonist. The EC50 for the inhibition of β-arrestin recruitment and cAMP production is 13.1 nM and 0.0053 nM, respectively.
T62722	SC13
	SC13 是一种新型的 mitragynine 类似物，具有低效Muopioid receptor 激动作用，具有麻醉作用和较轻的不良反应。
T27027	CJ-15208 CJ15,208,CJ-15,208,CJ 15,208.c[Phe-D-Pro-Phe-Trp]
	CJ-15208 is a potent and selective κ-opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502 (IC50 are 47 nM for kappa, 260 nM for mu, and 2,600 nM for delta respectly). In the electrically-stimulated twitch response assay of rabbit vas de
T40845	Methylnaltrexone iodide Naltrexonium methiodide,碘化甲基纳曲酮；碘甲纳曲酮
	Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor. Furthermore, Methylnaltrexone iodide exhibits limited permeability across the blood-brain barrier.
T4411	DAMGO TFA (78123-71-4(Free base))	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DAMGO TFA (78123-71-4(Free base)) 是Mu-opioid 受体的强效选择性激动剂。它也是镇痛药。它刺激钙激活的腺苷酸环化酶相关 cAMP 的产生。通过 TGF-beta1 表达趋化因子和趋化因子受体。增加老鼠的食物摄入量。
T75916	Dynorphin A TFA
	Dynorphin A TFA, 作为一种内源性阿片肽，主要在中枢神经系统（CNS）中发挥抑制性神经传导的作用。该化合物不仅是kappa阿片受体（KOR）的高效激动剂，还能激活其他阿片受体，包括mu（MOR）和delta（DOR）。Dynorphin A TFA具有诱导神经元死亡的能力，因此在神经系统疾病的研究中具有应用价值。
T27934	LY255582 LY-255582,LY 255582	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	LY255582 是一种具有选择性的中枢活性阿片受体拮抗剂，对 mu、delta 和 kappa 受体具有高亲和力，Ki 分别为 0.4 nM、5.2、2.0 nM。LY255582 可以抑制饮食相关的中脑边缘多巴胺水平的增加，并减少食物摄入的消耗。LY255582 常用于对肥胖的研究。LY255582是用于阿片受体介导的细胞信号传导研究的潜在化合物。
T78778	D3R/MOR antagonist 1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	D3R/MOR antagonist 1 (Compound 114) 为D3R/MOR拮抗剂，其对D3R和MOR的Ki值分别为46.5 nM和691 nM。该化合物通过MOR的部分激动作用可能具有镇痛效果，同时通过D3R的拮抗作用有助于降低阿片类药物的滥用风险。
T36722	Deltorphin II (trifluoroacetate salt)
	Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid...
T62805	SB-612111 hydrochloride
	SB-612111 hydrochloride 是一种高效的、新型的阿片受体孤儿受体 (ORL-1) 拮抗剂，对 hORL-1 具有较高的亲和力，Ki 值为 0.33 nM。SB-612111 hydrochloride 能够作用于 μ-receptor (Ki: 57.6 nM)，κ-receptor (Ki: 160.5 nM) 和 δ-receptor (Ki: 2109 nM)。SB-612111 hydrochloride 能有效拮抗 Nociceptin 在急性疼痛模型中的造成的痛觉作用。

化合物

Cat.No: T7748

Synonym: 皮啡肽三氟乙酸盐

Target: Others, Opioid Receptor

Mu opioid receptor antagonist 3

Cat.No: T62767

Cat.No: T7404

Synonym: 皮啡肽

Target: Opioid Receptor

Mu opioid receptor antagonist 5

Cat.No: T62673

Mu opioid receptor antagonist 2

Cat.No: T62766

Mu opioid receptor antagonist 4

Cat.No: T62768

Mu opioid receptor antagonist 7

Cat.No: T79431

Target: Opioid Receptor

Cat.No: T1242

Synonym: 爱维莫潘

Target: Opioid Receptor

Cat.No: T27667

Synonym: JNJ 20788560

Target: Opioid Receptor

Trimebutine maleate

Cat.No: T1197

Synonym: Debridat,Polibutin,马来酸曲美布汀

Target: Calcium Channel, Opioid Receptor

Cat.No: T31081

Synonym: CP 866087,UNII-MDH21334PI,CP-866,087,CP866087

Target: Opioid Receptor

Cat.No: T4407

Target: Opioid Receptor

1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride

Cat.No: T50091

Synonym: 1-(8-carbamimidamidooctyl)guanidine dihydrochloride

Target: Others

AT-121 hydrochloride

Cat.No: T39529

Target: Opioid Receptor

Cat.No: T10593

Target: Opioid Receptor

Tyr-Gly-Gly-Phe-Met-OH

Cat.No: T7211

Synonym: Methionine enkephalin,蛋氨酸脑啡肽,Met-Enkephalin,[MET5]脑啡肽

Target: Opioid Receptor

Cat.No: T0918

Synonym: 曲美布汀,Mebutin

Target: Opioid Receptor

Cat.No: T7306

Synonym: Valorphin TFAsalt

Target: Opioid Receptor

Cat.No: T25194

Synonym: BW443C,BW-443C,Tyr-arg-gly-(4-nitro-phe)-pro-NH2

Cat.No: T71189

Cat.No: T26918

Synonym: BU 08028,BU-08028

Oxycodegol phosphate

Cat.No: T70730

Alvimopan monohydrate

Cat.No: T1242L

Cat.No: T69121

CYT-1010 hydrochloride

Cat.No: T10926L

Target: Others

Cat.No: T60415

Cat.No: T71225

Oxicodegol trifluoroacetate

Cat.No: T71224

Cat.No: T10926

Target: Others

Cat.No: T62722

Cat.No: T27027

Synonym: CJ15,208,CJ-15,208,CJ 15,208.c[Phe-D-Pro-Phe-Trp]

Methylnaltrexone iodide

Cat.No: T40845

Synonym: Naltrexonium methiodide,碘化甲基纳曲酮；碘甲纳曲酮

DAMGO TFA (78123-71-4(Free base))

Cat.No: T4411

Target: Opioid Receptor

Dynorphin A TFA

Cat.No: T75916

Cat.No: T27934

Synonym: LY-255582,LY 255582

Target: Opioid Receptor

D3R/MOR antagonist 1

Cat.No: T78778

Target: Dopamine Receptor

Deltorphin II (trifluoroacetate salt)

Cat.No: T36722

SB-612111 hydrochloride

Cat.No: T62805

Cat. No.	Product Name	Target	Signaling Pathways
TN3367	Akuammidine	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively.
TN3368	Akuammigine	Opioid Receptor; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. Akuammidine also shows a preference for mu-opioid binding sites with Ki val

天然产物

Cat.No: TN3367

Target: Opioid Receptor

Cat.No: TN3368

Target: Opioid Receptor, Adrenergic Receptor

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