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13

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25049	Allethrin	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Allethrin 是拟除虫菊酯杀虫剂，是主要的驱蚊剂。它在大鼠睾丸癌细胞 (LC540) 中诱导氧化应激、细胞凋亡和钙释放。它还诱导 BCL-2、caspase-3 激活和细胞内钙的释放。
T8886	NITD-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂，可抑制 DENV RdRp 介导的 RNA 延伸。
T13102	TCMDC-135051	Others	Others
	TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂，具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变，破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。
T20325	Butyl cinnamate NSC71966,NSC-71966,NSC 71966
	Butyl cinnamate is an agent of mosquito repellent.
T24186	J 2931 J2931,NSC 321569,J-2931
	J 2931 is an inhibitor of mosquito larvae growth.
T33643	Nepetalactone MD(sub 1) 84,MDI 84
	Nepetalactone is found in the plant Nepeta parnassica and has high mosquito repellency properties.
T20459	N,N-Diethyl-p-toluamide NSC 5686,NSC-5686,NSC5686
	N, N-Diethyl-p-toluamide is an agent of mosquito repellent.
T20658	Etofenprox
	Etofenprox, a synthetic pyrethroid, has insecticidal efficacy against mosquito larvae & on non-target organisms.
T38817	Golgicide A-1 GCA-1,Golgicide A-1
	Golgicide A-1 (GCA-1) is a moderately potent cis-diastereomer variant of Golgicide A (GCA) specifically designed to inhibit mosquito reproduction.
T40833	ω-Hydroxy-DEET
	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
T64139	TCMDC-135051 TFA
	TCMDC-135051 TFA 是一种有效的、高度选择性的、低靶外毒性的蛋白激酶 PfCLK3 抑制剂，表现出抗寄生虫作用，其 EC50 值为 320 nM。TCMDC-135051 TFA 能够阻断滋养体到裂殖体的转变，破坏转录及抑制向蚊子载体的传播。
T63488	TCMDC-135051 hydrochloride
	TCMDC-135051 hydrochloride 是有效的、高度选择性的、低的靶外毒性的蛋白激酶 PfCLK3 抑制剂。TCMDC-135051 hydrochloride 能够阻断滋养体到裂殖体的转变，破坏转录并抑制向蚊子载体的传播，表现出具有抗寄生虫效果，其EC50值为320 nM。
T36584	HNMPA-(AM)3	Tyrosine Kinases	Tyrosine Kinase/Adaptors
	HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。

化合物

Cat.No: T25049

Target: BCL, Caspase

Cat.No: T8886

Target: DNA/RNA Synthesis

Cat.No: T13102

Target: Others

Butyl cinnamate

Cat.No: T20325

Synonym: NSC71966,NSC-71966,NSC 71966

Cat.No: T24186

Synonym: J2931,NSC 321569,J-2931

Cat.No: T33643

Synonym: MD(sub 1) 84,MDI 84

N,N-Diethyl-p-toluamide

Cat.No: T20459

Synonym: NSC 5686,NSC-5686,NSC5686

Cat.No: T20658

Cat.No: T38817

Synonym: GCA-1,Golgicide A-1

ω-Hydroxy-DEET

Cat.No: T40833

TCMDC-135051 TFA

Cat.No: T64139

TCMDC-135051 hydrochloride

Cat.No: T63488

Cat.No: T36584

Target: Tyrosine Kinases

Cat. No.	Product Name	Target	Signaling Pathways
TN6742	β-Damascone Damascone,大马酮	Others	Others
	β-Damascone 是具有香气活性的大米挥发物，普遍用于香水成分中。它具有用作癌症化学预防剂及蚊香类杀虫剂的潜力。
TN2261	Tectoquinone	Others	Others
	Tectoquinone 具有很强的杀蚊幼虫活性。
T5795	Suberosin 软木花椒素	Others; NF-κB	NF-κB; Others
	Suberosin 可分离自Plumbago zeylanica 中，通过调节NF-AT 和NF-κB，抑制PHA-诱导的 PBMC 细胞增殖并捕获细胞周期G1过渡到 S 期，具有抗炎和抗血凝的活性。
T6S0214	dl-Maackiain (+)-Maackiain,高丽槐素,Demethylpterocarpin	Apoptosis; Parasite	Apoptosis; Microbiology/Virology
	dl-Maackiain (Demethylpterocarpin) 是分离自Maackia amurensis Rupr.et Maxim 的一种杀幼虫剂，针对埃及伊蚊，其LD50为 21.95 μg/ ml。
T20609	Niloticin
	Niloticin is a mosquito insecticide from Limonia acidissima L.
TN3151	6-Acetonyl-N-methyl-dihydrodecarine	Antifection	Microbiology/Virology
	6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.
TN6053	Glycosolone
	Glycosolone shows some toxicity on mosquito larvae (Culex quinquefasciatus).
TN4641	Neoprocurcumenol	Others	Others
	Neoprocurcumenol exerts significant toxicity on mosquito larvae.
TN6453	Nardoaristolone B
	Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes. The novel mosquito-repellentsynthetic hydrindanesbased on noreremophilanes and nardoaristolone B which s
TN4026	Eucamalol	Others	Others
	Eucamolol exhibits significant repellent activity against Aedes albopictus, and inhibits its feeding as well as DEET, is effective repellent (75%) up to 3 h after exposure to mosquito.
TN3549	Burchellin	Antifection	Microbiology/Virology
	Burchellin has larvicidal activity, it can interfer with the development cycle of the mosquito, where its strongest toxic effect is 100% mortality in larvae (L3) at concentrations ¥ 30 ppm. Burchellin and licarin A have activity against Trypanosoma cruzi
TN3436	ar-Curcumene	Others	Others
	ar-Curcumene has antiinflammatory activity, it could be used as antiinflammatory drugs in respiratory infections. ar-Curcumene is effective as oviposition deterrents against Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus, it can be conside
TN4040	Eupatoriochromene	Antifection	Microbiology/Virology
	Eupatoriochromene retard seed germination , reduced radicle and hypocotyl growth of weed and crop plant seedlings and increased adventitious root formation of mung bean cuttings. Eupatoriochromene has insecticidal activity, it exhibits toxicity againstCul

天然产物

Cat.No: TN6742

Synonym: Damascone,大马酮

Target: Others

Cat.No: TN2261

Target: Others

Cat.No: T5795

Synonym: 软木花椒素

Target: Others, NF-κB

Cat.No: T6S0214

Synonym: (+)-Maackiain,高丽槐素,Demethylpterocarpin

Target: Apoptosis, Parasite

Cat.No: T20609

6-Acetonyl-N-methyl-dihydrodecarine

Cat.No: TN3151

Target: Antifection

Cat.No: TN6053

Neoprocurcumenol

Cat.No: TN4641

Target: Others

Nardoaristolone B

Cat.No: TN6453

Cat.No: TN4026

Target: Others

Cat.No: TN3549

Target: Antifection

Cat.No: TN3436

Target: Others

Eupatoriochromene

Cat.No: TN4040

Target: Antifection

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