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22

抑制剂 & 化合物

3

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Cat. No.	Product Name	Target	Signaling Pathways
T22026	AGK7	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态
T19062	Sulforhodamine 101 磺基罗丹明101,磺基罗丹明 101,SR101	Others	Others
	Sulforhodamine 101 (SR101) 是一种两性罗丹明红色荧光染料 (excitation/emission: 586/605 nm)，常用于神经元形态的研究，并作为星形胶质细胞的细胞类型选择性荧光标记物，在体内和切片制备中都有应用。
T15220	Enbucrilate 恩布酯,Butyl cyanoacrylate	Others	Others
	Enbucrilate (Butyl cyanoacrylate) 是一种氰基丙烯酸酯，已被用作手术组织粘合剂。
T5580	1-Naphthaleneacetic acid potassium salt α-萘醋酸钾,α-Naphthaleneacetic acid,Potassium alpha-naphthylacetate,Potassium 1-Naphthaleneacetate,1-NAA Potassium Salt	Phospholipase	Metabolism
	1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) 是一种合成的植物生长素，能够促进植物生长，也是一种PLA2抑制剂，IC50=13.16 μM。
T10460	Batabulin 巴他布林,T138067	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞，最终诱导细胞凋亡。
T11888	LtaS-IN-1	Others; Antibacterial	Microbiology/Virology; Others
	LtaS-IN-1 是多药耐药粪肠球菌中脂磷壁酸合成的有效抑制剂，可改变细胞壁形态。 LtaS-IN-1 对抗肠球菌属 28 菌株，MIC 值从 0.5 μg/mL 到 64 μg/mL 不等。 LtaS-IN-1 抑制菌株 E1630 和 E1590，MIC 值为 0.5 μg/mL。
T61616	Antitumor agent-38
	Antitumor agent-38 is a highly effective antitumor compound that exhibits antiproliferative activity towards cancer cells. It induces cell cycle arrest specifically at the late S and G2/M phase, while not impeding microtubule formation or altering cell morphology [1].
T39172	SMAP-29
	SMAP-29 is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide with strong potential as an antiinfective agent. It effectively permeabilizes bacterial membranes and induces significant alterations in the surface morphology of susceptible microorganisms.
T11042	Dihydrocytochalasin B	Others	Others
	Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
T81685	NEP(1-40) TFA
	NEP(1-40) TFA 是一种Nogo-66 受体 (NgR) 的肽类拮抗剂，其作用机制为通过抑制髓蛋白所引发的损伤逆转，限制小胶质细胞形态分布的变化。
T61265	Exo2
	Exo2 is a secretion inhibitor that hinders the trafficking of Shiga toxin from endosomes to the trans-Golgi network. It inhibits the exit of secretory cargo from the endoplasmic reticulum (ER) and disrupts the Golgi apparatus. Notably, Exo2 does not impact the morphology of the trans-Golgi network (TGN). Additionally, Exo2 has the ability to induce calcium-dependent exocytosis in permeabilized adrenal chromaffin cells [1] [2].
T71420	RO314724
	RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.
T41342	Batabulin sodium
	Batabulin sodium (T138067 sodium) 是一种抗肿瘤剂，可共价且选择性地修饰 β-微管蛋白同种型子集，从而破坏微管 (microtubule) 聚合。Batabulin sodium 影响细胞形态并导致细胞周期停滞，诱导凋亡性细胞死亡。
T81434	PNE-Lyso
	PNE-Lyso是一种可通过双重荧光信号监测细胞内pH值及N-acetylhexosaminidase活性的活性荧光探针。该探针能够通过溶酶体形态变化实现凋亡与坏死的鉴别，适用于研究活性分子引起的细胞死亡机制。
T79408	KGP591
	KGP591为微管蛋白聚合抑制剂（IC50 0.57µM），能显著诱导MDA-MB-231细胞G2/M停滞，同时抑制细胞迁移，破坏微管结构及细胞形态。在RENCA原位肾癌模型中，KGP591展现了抗肿瘤活性。
T62743	AChE-IN-10
	AChE-IN-10 (Compound 24r) 是一种 AChE 的有效抑制剂，其 IC50 值为 2.4 nM。AChE-IN-10 在 AChE 存在下能够降低淀粉样蛋白的聚集。AChE-IN-10 对 AChE 表现出有效抑制作用，可以降低 S396 残基的 tau 磷酸化，挽救神经元形态和增加细胞活力，进而提供神经保护作用。
T78899	Laccase-IN-1
	Laccase-IN-1 (compound 4b) 是一种口服laccase抑制剂，其IC50为11.3 μM。该化合物能够对苹果中的B. dothidea起到保护及治疗效果。它通过增强B. dothidea细胞膜的通透性、破坏其菌丝的表面形态以及细胞的超微结构，并且减少麦角甾醇和胞外多糖的含量，来发挥作用。
T80173	BDS-I	Potassium Channel	Membrane transporter/Ion channel
	BDS-I，又名降血物质，源自苏卡达银莲花的海洋毒素。它作为钾通道特异性抑制剂，针对Kv3.4。BDS-I能够抑制由Aβ1-42诱导的Kv3.4活性增强，减少caspase-3的激活，阻止NGF诱导的PC-12细胞分化以及异常核形态的出现，并可逆转Aβ肽引发的细胞死亡。
T4620	Siramesine 西拉美新,Lu 28-179	Sigma receptor	GPCR/G Protein
	Siramesine (Lu 28-179) 是sigma-2受体激动剂，通过线粒体的不稳定溶酶体触发细胞死亡，有强大的抗癌活性。它对 sigma-2 受体具有亚纳摩尔亲和力，IC50为 0.12 nM。它对 sigma-2 受体的选择性是 sigma-1 受体的 140倍，IC50为 17 nM。
T72227	PI3K/Akt/CREB activator 1
	PI3K/Akt/CREB activator 1 是一种口服有效的PI3K/Akt/CREB 的激活剂。PI3K/Akt/CREB activator 1 通过 PI3K/Akt/CREB 通路上调脑源性神经营养因子，促进神经元增殖，诱导 Neuro-2a 细胞分化成神经元样形态，加速海马原代神经元轴突-树突极化的建立。PI3K/Akt/CREB activator 1 可用于血管性痴呆 (VaD) 的研究。
T36107	YW3-56 YW3-56
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...

化合物

Cat.No: T22026

Target: Others, Sirtuin

Sulforhodamine 101

Cat.No: T19062

Synonym: 磺基罗丹明101,磺基罗丹明 101,SR101

Target: Others

Cat.No: T15220

Synonym: 恩布酯,Butyl cyanoacrylate

Target: Others

1-Naphthaleneacetic acid potassium salt

Cat.No: T5580

Synonym: α-萘醋酸钾,α-Naphthaleneacetic acid,Potassium alpha-naphthylacetate,Potassium 1-Naphthaleneacetate,1-NAA Potassium Salt

Target: Phospholipase

Cat.No: T10460

Synonym: 巴他布林,T138067

Target: Apoptosis, Microtubule Associated

Cat.No: T11888

Target: Others, Antibacterial

Antitumor agent-38

Cat.No: T61616

Cat.No: T39172

Dihydrocytochalasin B

Cat.No: T11042

Target: Others

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

Cat.No: T81685

Cat.No: T61265

Cat.No: T71420

Batabulin sodium

Cat.No: T41342

Cat.No: T81434

Cat.No: T79408

Cat.No: T62743

Cat.No: T78899

Cat.No: T80173

Target: Potassium Channel

Cat.No: T4620

Synonym: 西拉美新,Lu 28-179

Target: Sigma receptor

PI3K/Akt/CREB activator 1

Cat.No: T72227

Cat.No: T36107

Synonym: YW3-56

Cat. No.	Product Name	Target	Signaling Pathways
T35895	Ingenol 3,20-dibenzoate
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].
T75576	Solidagonic acid
	Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡，并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Ingenol 3,20-dibenzoate

Cat.No: T35895

Solidagonic acid

Cat.No: T75576

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

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