12
3
Cat. No. | Product Name | Target | Signaling Pathways |
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T21715 |
BRD6688
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中,它可透过血脑屏障,并改善由p25 引起的神经退行性病变相关的记忆缺陷。 | |||
T16816 |
S 18986
|
GluR | Neuroscience |
S 18986是一种选择性、可口服活性、能渗透大脑的AMPA型受体阳性异构体调节剂,在啮齿动物中展示出增强认知的特性。它在大鼠海马体内诱导去甲肾上腺素和乙酰胆碱的释放,从而提高了对象识别记忆能力。 | |||
T67955 |
Ensaculin
Anseculin |
||
Ensaculin (Anseculin) 是一种用哌嗪部分取代的新型苯并吡喃酮,在正常和人工遗忘啮齿动物的被动和条件回避范式中显示出记忆增强作用。它在NMDA 毒性模型中表现出神经保护活性,在原代培养的大鼠脑细胞中表现出神经营养作用。Ensaculin 可用于治疗痴呆。 | |||
T8720 |
PRX-07034 hydrochloride
PRX-07034 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂,Ki 为 4-8 nM,IC50为 19 nM,可用于增强工作记忆和认知灵活性的研究。 | |||
T14977 | CL-275838 | Others | Others |
CL-275838 is a compound of memory-enhancing with potent antidepressant activities. | |||
T23821 |
BRD4884
BRD-4884,BRD 4884 |
||
BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes. | |||
T27195 |
DNS-8254
|
||
DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) inhibitor for the treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object reco | |||
T70075 |
KDS2010 mesylate
|
||
KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice. | |||
T27269 |
Ensaculin HCl
KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl |
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Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e | |||
T61603 | H3R antagonist 2 | ||
H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist. It exhibits inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. With a Ki of 170 nM for hH3R, H3R antagonist 2 demonstrates favorable anti-neuropathic pain and memory-enhancing effects. Additionally, it can cross the blood-brain barrier (BBB) [1]. | |||
T26366L |
Prasterone sulfate sodium hydrate
Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate |
||
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me | |||
T78596 | CAD031 | ||
CAD031,一种针对阿尔茨海默病 (AD) 的J147衍生物,展现了神经保护和记忆增强的特性。它能增强小鼠的记忆力,优化树突结构,并促进老年小鼠大脑生发区细胞的分裂。相较于J147,CAD031在人类神经干细胞测定中显示出更高的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2718 |
Palmatine chloride
|
Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others |
Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,并改善 DSS 诱发的结肠炎。 | |||
T5S0802 |
Palmatine
巴马汀,Berbericinine,Burasaine |
Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience |
Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。 | |||
T2883 |
Syringic acid
3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,丁香酸,NSC 2129 |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) 能抑制低密度脂蛋白的氧化。 |