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Search Results for " lipoproteins "

12

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14667	BLT-1	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	BLT-1 是一种氨基硫脲铜螯合剂，是一种选择性清除受体 B1 型 (SR-BI) 抑制剂，抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。
T0841	Bezafibrate BM15075,苯扎贝特	PPAR	DNA Damage/DNA Repair; Metabolism
	Bezafibrate (BM15075) 是一种降血脂剂，是PPAR 的激动剂，对人以及鼠PPARα、PPARγ和PPARδ的EC50分别为 50、60和20 μM，以及 90、55 和110 μM。
T15947	MAC13243 HCl	Antibacterial	Microbiology/Virology
	MAC13243 HCl 是一种将脂蛋白从内膜运输到外膜的周质伴侣LolA的抑制剂，是一种具有特异性的抗菌剂，对革兰氏阴性菌抑制作用显著。
T40418	DiO DiOC18(3),3,3'-Dioctadecyloxacarbocyanine perchlorate	Others	Others
	DiO (DiOC18(3)) 是一种荧光亲脂性示踪剂，可广泛用于标记细胞、细胞器、脂质体、病毒和脂蛋白。
T22405	Pravastatin	Others	Others
	Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
T35603	Oleic Acid-2,6-diisopropylanilide
	AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
T83423	1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine
	1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine 是一种荧光探针，其极性磷脂酰乙醇胺头基适用于测定脂蛋白与血浆表面脂质的氧化。
T36549	CAY10486
	Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM.
TP2282L	Pam2CSK4 TFA PUL-042 TFA,ODN-M362 TFA,Pam2CSK4 trifluoroacetate-salt,Pam2CSK4 TFA(868247-72-7 Free base）	TLR; Antifungal	Immunology/Inflammation; Microbiology/Virology
	Pam2CSK4 TFA (PUL-042 TFA) 是一种有效的 TLR2 和 TLR6 双重激动剂，是一种模拟细菌脂蛋白的多肽。Pam2CSK4 TFA 可促进血小板聚集，可用来研究脂蛋白对牙周的影响。
T35984	CAY10485
	Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.
T38000	Lysosphingomyelin (d18:1)
	Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between ...
T37187	D-erythro/L-threo Lysosphingomyelin (d18:1) D-erythro/L-threo Lysosphingomyelin (d18:1)
	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O...

化合物

Cat.No: T14667

Target: Others, HCV Protease

Cat.No: T0841

Synonym: BM15075,苯扎贝特

Target: PPAR

Cat.No: T15947

Target: Antibacterial

Cat.No: T40418

Synonym: DiOC18(3),3,3'-Dioctadecyloxacarbocyanine perchlorate

Target: Others

Cat.No: T22405

Target: Others

Oleic Acid-2,6-diisopropylanilide

Cat.No: T35603

1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine

Cat.No: T83423

Cat.No: T36549

Cat.No: TP2282L

Synonym: PUL-042 TFA,ODN-M362 TFA,Pam2CSK4 trifluoroacetate-salt,Pam2CSK4 TFA(868247-72-7 Free base）

Target: TLR, Antifungal

Cat.No: T35984

Lysosphingomyelin (d18:1)

Cat.No: T38000

D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat.No: T37187

Synonym: D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat. No.	Product Name	Target	Signaling Pathways
TN2364	Sudan IV 苏丹红Ⅳ,Solvent Red 24,C.I. 26105	Others	Others
	Sudan IV (Solvent Red 24) 是脂溶性重氮染料，可用于冰冻或石蜡切片上，能够将脂类、甘油三酯和脂蛋白染色。
T4775	Arachidic acid eicosanoic acid,Icosanoic Acid,花生酸	Others; Endogenous Metabolite	Metabolism; Others
	Arachidic acid (Icosanoic Acid) 是一种存在于所有哺乳动物细胞中的长链脂肪酸，通常酯化为膜磷脂，是人体组织中丰富的多不饱和脂肪酸之一。
T5227	Tricaprin Tridecanoin,Glyceryl tridecanoate,Glycerol Tridecanoate,TG(10:0/10:0/10:0),Glycerol tricaprate,甘油三癸酸酯,三癸酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Tricaprin (Glycerol Tridecanoate) 是癸酸的一种口服具有活性前体 (DA precursor)，能够被水解为癸酸。它是中链甘油三酸酯 (MCT) 的主要成分，具有抗雄激素和抗高血糖特性。它能够用做食品，药品，化妆品中的添加剂。
T1664	Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托	Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂，可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
TN4600	Myrianthic acid	PAFR; AChR	GPCR/G Protein; Neuroscience
	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 uM concentration. Myrianthic acid is equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation.

天然产物

Cat.No: TN2364

Synonym: 苏丹红Ⅳ,Solvent Red 24,C.I. 26105

Target: Others

Cat.No: T4775

Synonym: eicosanoic acid,Icosanoic Acid,花生酸

Target: Others, Endogenous Metabolite

Cat.No: T5227

Synonym: Tridecanoin,Glyceryl tridecanoate,Glycerol Tridecanoate,TG(10:0/10:0/10:0),Glycerol tricaprate,甘油三癸酸酯,三癸酸甘油酯

Target: Others, Endogenous Metabolite

Cat.No: T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Myrianthic acid

Cat.No: TN4600

Target: PAFR, AChR

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