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Cat. No.	Product Name	Target	Signaling Pathways
T14779	BRD7389	SGK; FLT; Pim; CDK; S6 Kinase; DAPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	BRD7389 是一种 RSK 家族激酶抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。
T6793	BRD7552	Others	Others
	BRD7552 是PDX1转录因子诱导剂，它能够上调人类原代胰岛和导管细胞中 PDX1 的表达，诱导 PDX1 启动子的表观遗传变化与转录激活一致，提高胰岛素表达。其中 PDX1 是参与胰腺发育和β细胞功能的关键转录因子。
T7658	Dimethyl DL-Glutamate (hydrochloride)	Others	Others
	Dimethyl DL-Glutamate (hydrochloride) 是一种细胞渗透性谷氨酸衍生物，可在孤立的胰岛和糖尿病动物模型中增强胰岛素释放以响应葡萄糖。
T83972	NOX-6-18 GPR132 antagonist 1,GPR132-B-160	GPR	Endocrinology/Hormones; GPCR/G Protein
	NOX-6-18 (GPR132-B-160) 是一种具有高效性和选择性的 GPR132 拮抗剂，具有促进胰岛素分泌活性，可以调节胰岛内的巨噬细胞重编程，减少体重增加。
T78097L	Mazdutide acetate（2259884-03-0 free base） Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate	Glucagon Receptor	GPCR/G Protein
	Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂，是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌，可用于研究肥胖和 2 型糖尿病 (T2D) 。
T15368L	Galantide acetate Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂，是一种由甘丙肽和 P 物质片段组成的肽段，在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。
T26172	S3QEL-2 S3QEL2,S3QEL 2
	S3QEL-2 is a retrograde signaling modulator. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets.
T71346	MS4
	MS4 is a novel glucocorticoid receptor (GR) agonist with anti-inflammatory activity and displaying reduced impact on islets.
T70113	ATM-1001
	ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets.
TP1519	Amylin (IAPP), feline
	Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.
T11401	GKA50	Others	Others
	GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).
T71020	PF-04671536
	PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.
TP1863	Glucagon (19-29), human
	Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing endocrine pancreas.
T24169	Insulin B (22-30) Insulin (B22-B30)
	Insulin B (22-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into la
T63019	GKA50 quarterhydrate
	GKA50 quarterhydrate 是一种有效的葡萄糖激酶激活剂，其 EC50 值为 33 nM。GKA50 quarterhydrate 是一种啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，也是一种 Ca2+依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 能够刺激小鼠胰岛分泌胰岛素，可以显著降低高脂喂养的雌性大鼠血糖。
T24168	Insulin B (20-30) Insulin (B20-B30)
	Insulin B (20-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into la
TP1954	PHM-27 (human)
	Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insu
T26868	BMS-986118 BMS 986118
	BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a
TP1662	Galanin Receptor Ligand M35
	The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and perf
T80149	GRPP (human)
	GRPP (human)为含有30个氨基酸的Gcg衍生肽。该化合物能引起血浆胰岛素的轻微上升及血浆胰高血糖素的轻微降低，但不会影响大鼠胰岛内的胰岛素分泌。
T29154	WB403 WB-403,WB 403
	WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-
T76028	Amylin (IAPP), feline TFA
	Amylin (IAPP), feline TFA，一种来自猫科动物、含37个氨基酸的多肽，为胰岛β细胞的主要分泌物之一。作为调节肽，它能够抑制胰岛素和胰高血糖素的分泌。
T21681	AACOCF3 Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane	Phospholipase	Metabolism
	AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 ...
TP1302	Somatostatin
	Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and
T73610	Lipoprotein lipase
	Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。
TP1301	Orexin A (human, rat, mouse)
	Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse has been used to study its effect on the functioning of porcine pancreatic islets. It has also been used as an orexin receptor 1 (OX1R) agonist to study the effect of orexin systems in the effect of etonogestrel on respiratory response to prolonged metabolic acidosis.
T74568	Phospholipid-PEG-Biotin (MW 20000)
	Phospholipid-PEG-Biotin (MW 20000) 与 Phospholipid-PEG-Biotin (MW 3400) 均为磷脂和生物素通过线性 PEG 连接剂桥接形成的磷脂聚乙二醇衍生物。其中，Phospholipid-PEG-Biotin (MW 3400) 能与亲和抗体进行相互作用，并可用于修饰脂质体、细胞表面及胰岛细胞移植。
TP1044	Pancreatic Polypeptide, rat Rat pancreatic polypeptide
	Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cel
T74567	Phospholipid-PEG-Biotin (MW 10000)
	Phospholipid-PEG-Biotin (MW 10000)与Phospholipid-PEG-Biotin (MW 3400)均为磷脂与生物素通过线性PEG连接剂桥接形成的聚乙二醇衍生物。Phospholipid-PEG-Biotin (MW 3400) 能与亲和抗体相互作用，用于脂质体和细胞表面的修饰以及胰岛细胞的移植。
T74564	Phospholipid-PEG-Biotin (MW 2000)
	Phospholipid-PEG-Biotin (MW 2000) 是一种PROTAClinker，属于 PEG 类。可用于合成PROTAC 分子。Phospholipid 是一类含有亲水“头”和疏水“尾”的脂类；PEG 是一种低毒性的亲水水溶性聚合物；生物素是一种酶辅因子，可用于标记蛋白质。
T74565	Phospholipid-PEG-Biotin (MW 3400)
	Phospholipid-PEG-Biotin (MW 3400) 为一种通过线性PEG链接剂桥接磷脂和生物素的磷脂聚乙二醇衍生物。该化合物能够与亲和抗体进行相互作用，并可用于脂质体及细胞表面的修饰，也适用于胰岛细胞移植。
T74566	Phospholipid-PEG-Biotin (MW 5000)
	Phospholipid-PEG-Biotin (MW 5000)为含有磷脂的PEG衍生物，适用于脂质体和细胞表面的修饰，及胰岛细胞移植。Phospholipid具亲水性“头部”与疏水性“尾部”结构，PEG为亲水性低毒聚合物，生物素则作为酶辅因子，用于蛋白质标记。
T35627	Amylin (human) (trifluoroacetate salt)
	Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cro...
TP2071	Bay 55-9837
	Selective VPAC2 receptor agonist (EC50 values are 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50 values are 60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively in a competition binding assay). S
T74563	Phospholipid-PEG-Biotin (MW 1000)
	Phospholipid-PEG-Biotin (MW 1000) 和 Phospholipid-PEG-Biotin (MW 3400) 均为磷脂与生物素通过线性聚乙二醇(PEG)连接桥接得到的衍生物。其中，Phospholipid-PEG-Biotin (MW 3400) 能够与亲和抗体发生相互作用，适用于脂质体和细胞表面的修饰，以及胰岛细胞移植领域。
T36070	(±)5(6)-EET
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...
T35598	Neuromedin U-25 (human) (trifluoroacetate salt)
	Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ...
T35622	FKGK 18
	FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits gl...
T83928	DA ZP1
	DA ZP1（diacetylated Zinpyr1）是一种荧光性的Zn(II)传感器（KdZn2+= 0.6 nM），可用于体外成像和分离胰腺β细胞及类似β细胞，并用于纯化源自干细胞的活体类似β细胞。该传感器亦可用于体内成像移植的岛细胞移植物和内源性小鼠岛细胞。在没有Zn(II)离子存在时，DA ZP1不发光，但其与Zn(II)的结合促进乙酰基的水解裂解，产生强烈的荧光信号。其激发和发射最大波长（λ）分别为490 nm和522 nm。
T35794	Kisspeptin-54 (human) (trifluoroacetate salt)
	Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...

化合物

Cat.No: T14779

Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK

Cat.No: T6793

Target: Others

Dimethyl DL-Glutamate (hydrochloride)

Cat.No: T7658

Target: Others

Cat.No: T83972

Synonym: GPR132 antagonist 1,GPR132-B-160

Target: GPR

Mazdutide acetate（2259884-03-0 free base）

Cat.No: T78097L

Synonym: Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate

Target: Glucagon Receptor

Galantide acetate

Cat.No: T15368L

Synonym: Galantide acetate(138579-66-5 Free base)

Target: Neuropeptide Y Receptor

Cat.No: T26172

Synonym: S3QEL2,S3QEL 2

Cat.No: T71346

Cat.No: T70113

Amylin (IAPP), feline

Cat.No: TP1519

Cat.No: T11401

Target: Others

Cat.No: T71020

Glucagon (19-29), human

Cat.No: TP1863

Insulin B (22-30)

Cat.No: T24169

Synonym: Insulin (B22-B30)

GKA50 quarterhydrate

Cat.No: T63019

Insulin B (20-30)

Cat.No: T24168

Synonym: Insulin (B20-B30)

Cat.No: TP1954

Cat.No: T26868

Synonym: BMS 986118

Galanin Receptor Ligand M35

Cat.No: TP1662

Cat.No: T80149

Cat.No: T29154

Synonym: WB-403,WB 403

Amylin (IAPP), feline TFA

Cat.No: T76028

Cat.No: T21681

Synonym: Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane

Target: Phospholipase

Cat.No: TP1302

Lipoprotein lipase

Cat.No: T73610

Orexin A (human, rat, mouse)

Cat.No: TP1301

Phospholipid-PEG-Biotin (MW 20000)

Cat.No: T74568

Pancreatic Polypeptide, rat

Cat.No: TP1044

Synonym: Rat pancreatic polypeptide

Phospholipid-PEG-Biotin (MW 10000)

Cat.No: T74567

Phospholipid-PEG-Biotin (MW 2000)

Cat.No: T74564

Phospholipid-PEG-Biotin (MW 3400)

Cat.No: T74565

Phospholipid-PEG-Biotin (MW 5000)

Cat.No: T74566

Amylin (human) (trifluoroacetate salt)

Cat.No: T35627

Cat.No: TP2071

Phospholipid-PEG-Biotin (MW 1000)

Cat.No: T74563

Cat.No: T36070

Neuromedin U-25 (human) (trifluoroacetate salt)

Cat.No: T35598

Cat.No: T35622

Cat.No: T83928

Kisspeptin-54 (human) (trifluoroacetate salt)

Cat.No: T35794

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