Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T25376 |
Ensifentrine
Ensifentrina,Ensifentrinum |
PDE | Metabolism |
Ensifentrine (Ensifentrinum) 是首创的吸入式磷酸二酯酶 3 (PDE3) 和PDE4双重抑制剂,IC50分别为 0.4 nM 和 1479 nM。它具有支气管保护和抗炎作用,可用于研究慢性阻塞性肺疾病 (COPD) 。 | |||
T0094 |
Budesonide
Entocort,Pulmicort,布地奈德,Rhinocort |
Glucocorticoid Receptor | Endocrinology/Hormones |
Budesonide (Pulmicort) 是吸入型糖皮质类固醇,是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积,逆转 DNA 低度甲基化,调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。 | |||
T9124 |
Laninamivir octanoate
辛酸拉尼米韦,CS-8958 |
Influenza Virus | Microbiology/Virology |
Laninamivir octanoate (CS-8958) 是一种长效流感神经氨酸酶抑制剂,是Laninamivir 的前药, 具有优异的抗流感病毒活性。 | |||
T5159 |
Olodaterol hydrochloride
BI-1744 HCl,盐酸奥达特罗,BI 1744 hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Olodaterol hydrochloride (BI-1744 HCl) 是一种长效的、选择性 β2-adrenoceptor(β2-AR) 激动剂 (EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor),可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化的研究。 | |||
T5121 |
TD139
|
Galectin | Immunology/Inflammation |
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。 | |||
T8900 |
Seralutinib
GB002 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂,可用于研究肺动脉高压。 | |||
T9826 |
GDC-0214
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
GDC-0214 是一种吸入式小分子 JAK1 抑制剂,可降低呼出一氧化氮 (Feno) 的分数。 | |||
T14377 |
AZD5423
|
Glucocorticoid Receptor | Endocrinology/Hormones |
AZD5423 是可吸入的非甾体糖皮质激素受体选择性调节剂,能够有效降改善轻度过敏性哮喘患者的过敏原诱导反应。 | |||
T72918 |
JNJ-49095397
RV568 |
||
JNJ-49095397 (RV568) 是一种吸入性窄谱激酶抑制剂 (NSKI),可抑制p38 MAPK 的 α 和 γ 亚型。JNJ-49095397 还抑制SRCkinase 家族,特别是造血激酶(HCK),显示出强大的抗炎作用,可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。 | |||
T68272 |
Batefenterol Succinate
|
||
Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. | |||
T35319 |
Zy 15109
N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate |
||
Zy 15109 can be used as inhaled mast cell stabilizer. | |||
T25136 |
Aztreonam lysine
Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate |
||
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). | |||
T30264 |
Navafenterol
AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351 |
||
AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). | |||
T39684 |
AZD8154
AZD8154 |
||
AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. | |||
T70402 | LAS195319 | ||
LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases. | |||
T29518 |
Abediterol
LAS100977,LAS 100977,LAS-100977 |
||
Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease. | |||
T16439 |
PC786
|
Others | Others |
PC786 shows effective antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM). PC786 is an inhaled respiratory syncytial virus L protein polymerase inhibitor. | |||
T16477 | PF-03715455 | p38 MAPK | MAPK |
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-0371545 | |||
T63709 | Nezulcitinib | ||
Nezulcitinib (TD-0903) 是一种吸入的、肺选择性的 pan-Janus kinase (JAK) 抑制剂,能够用于研究 COVID-19 相关急性肺损伤及氧合受损。 | |||
T67962 | sulukast | ||
Sulukast 是一种有效的吸入白三烯拮抗剂,在豚鼠中被发现可有效预防白三烯和抗原诱导的支气管痉挛。 | |||
T69059 |
Cromoglicate sodium hydrate
|
||
Cromoglicic acid , cromolyn (USAN), cromoglycate (former BAN), or cromoglicate, is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cro... |