Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 995 | 现货 | ||
2 mg | ¥ 1,578 | 现货 | ||
5 mg | ¥ 2,686 | 现货 | ||
10 mg | ¥ 3,880 | 现货 | ||
25 mg | ¥ 6,230 | 现货 | ||
50 mg | ¥ 8,560 | 现货 | ||
100 mg | ¥ 11,500 | 现货 |
产品描述 | TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM). |
靶点活性 | GAL3:14 nM (Kd) |
体外活性 | TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1]. |
体内活性 | In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by the decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139 [1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and prevents the apoptosis of liver-infiltrating MNCs [2]. |
化合物与蛋白结合的复合物 |
Crystal Structure of Human Galectin-7 in Complex with TD139 |
分子量 | 648.64 |
分子式 | C28H30F2N6O8S |
CAS No. | 1450824-22-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
Ethanol: 3 mg/mL
DMSO: 55 mg/mL (84.79 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5417 mL | 7.7084 mL | 15.4169 mL | 38.5422 mL |
5 mM | 0.3083 mL | 1.5417 mL | 3.0834 mL | 7.7084 mL | |
10 mM | 0.1542 mL | 0.7708 mL | 1.5417 mL | 3.8542 mL | |
20 mM | 0.0771 mL | 0.3854 mL | 0.7708 mL | 1.9271 mL | |
50 mM | 0.0308 mL | 0.1542 mL | 0.3083 mL | 0.7708 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TD139 1450824-22-2 Immunology/Inflammation Galectin TD-139 TD 139 Inhibitor inhibitor inhibit