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Cat. No.	Product Name	Target	Signaling Pathways
T9683	VX-150	Sodium Channel	Membrane transporter/Ion channel
	VX-150 是一种口服有效的，高选择性的 NaV1.8抑制剂。VX-150 在各种疼痛适应症中有研究的价值。
T5444	CLP290 CLP-290	Potassium Channel	Membrane transporter/Ion channel
	CLP-290 是一种神经特异性 K+-Cl−共转运体 KCC2的口服激活剂，在多种神经和精神疾病方面具有研究潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。
T2270	Trans-Tranilast Tranilast trans-,反式-曲尼司特,反-曲尼司特	RAAS	Endocrinology/Hormones
	Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T60351	Acetazolamide sodium OT-302 sodium	Carbonic Anhydrase	Metabolism
	Acetazolamide sodium (OT-302 sodium) 是一种高效的碳酸酐酶 (CA)IX抑制剂，具有利尿、抗淋球菌和降压活性，可用于癫痫、青光眼、水肿和高原反应等适应症。
T23936	D-4418
	D-4418 is a PDE4 inhibitor. It has been in development as a novel anti-inflammatory therapy with asthma and chronic obstructive pulmonary disease being primary indications.
T70393	PF-303
	PF-303 is a covalent-reversible BTK inhibitor. Inhibitors of Bruton's tyrosine kinase (BTK) possess much promise for the treatment of oncologic and autoimmune indications.
T68557	PF-376304
	PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.
T27568	IACS-010759 hydrochloride IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I
T21324	R306465 R-306465,JNJ 16241199,R 306465,JNJ-16241199,JNJ16241199
	R306465 is a potent inhibitor of HDAC1 and -8 (class I) in vitro. It potently inhibited cell proliferation of all main solid tumour indications, including colon, ovarian, breast, lung and prostate cancer cell lines with IC50 values ranging from 30 to 300
T61820	Ar-V7-IN-1
	Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indications, notably cancers such as prostate cancer[1].
T71624	GB1874
	GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth of CRC tumor xenografts in vivo, thus demonstrating its potential for further development into therapeutics against Wnt-associated cancer indications.
T37905	Hexanoyl Glycine
	Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during...
T14614	Biperiden Hydrochloride KL 373 (Hydrochloride),盐酸比哌立登	Others	Others
	Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arte
T14359	AVX 13616	Others	Others
	AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i

化合物

Cat.No: T9683

Target: Sodium Channel

Cat.No: T5444

Synonym: CLP-290

Target: Potassium Channel

Trans-Tranilast

Cat.No: T2270

Synonym: Tranilast trans-,反式-曲尼司特,反-曲尼司特

Target: RAAS

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Acetazolamide sodium

Cat.No: T60351

Synonym: OT-302 sodium

Target: Carbonic Anhydrase

Cat.No: T23936

Cat.No: T70393

Cat.No: T68557

IACS-010759 hydrochloride

Cat.No: T27568

Synonym: IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759

Cat.No: T21324

Synonym: R-306465,JNJ 16241199,R 306465,JNJ-16241199,JNJ16241199

Cat.No: T61820

Cat.No: T71624

Hexanoyl Glycine

Cat.No: T37905

Biperiden Hydrochloride

Cat.No: T14614

Synonym: KL 373 (Hydrochloride),盐酸比哌立登

Target: Others

Cat.No: T14359

Target: Others

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