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Cat. No.	Product Name	Target	Signaling Pathways
TQ0046	Bavisant JNJ-31001074	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。
T10871	CP-809101 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	CP-809101 hydrochloride 是选择性 5-HT2C 受体激动剂，对于人类 5-HT2C/5-HT2B/5-HT2A 受体。
T2150	Guanfacine hydrochloride 盐酸胍法辛,Tenex,Intuniv,Guanfacine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂，Kd=31 nM，具有抗高血压作用。
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T60201	CX717	GluR	Neuroscience
	CX 717 是 AMPA 受体的正变构调节剂，具有抗抑郁样作用。CX 717 可用于成人注意力缺陷多动障碍（ADHD）的研究。
T33816	Ordopidine ACR-325,ACR 325,ACR325	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ordopidine (ACR325) 是一种多巴胺能稳定剂，可抑制精神刺激剂引起的多动症，并在不活动时刺激行为。Ordopidine 在体外作为多巴胺 D2 受体拮抗剂起作用，尽管亲和力低，但其依赖于特定状态的行为效应特征是 D2 受体拮抗剂所不具备的。
T13133	Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力，其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。
T12054L	MK-0249 FA MK-0249 FA(862309-06-6 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 FA 是一种具有口服活性、选择性和高效性的组胺 H3 反向激动剂，可用于研究成人注意力缺陷、多动症神经分裂和认知障碍。
T31604	Edivoxetine LY-2216684,LY 2216684,LY2216684
	Edivoxetine( LY2216684) is a selective norepinephrine reuptake inhibitor being developed as a treatment for attention deficit hyperactivity disorder (ADHD) and antidepressants.
T14970	Cipralisant GT-2331	Others	Others
	Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde
T32224	Isopropamide Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid
	Isopropamide (R5) is a long-acting anticholinergic drug. It is used to treat peptic ulcers and other gastrointestinal disorders involving excess gastric acid (gastrointestinal acidosis) and hyperactivity.
T10226	Sofiniclin ABT 894	Others	Others
	Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD).
T34752	Samelisant dihydrochloride SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl
	Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.
T61544	Edivoxetine hydrochloride
	Edivoxetine hydrochloride is a highly effective and specialized compound used primarily as a norepinephrine reuptake inhibitor (NERI), indicated for the treatment of depressive disorder and attention-deficit/hyperactivity disorder.
T79802	5-HT2C agonist-3	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2C agonist-3 ((+)-19)为高选择性5-HT2C激动剂，其EC50为24 nM，Ki值为78 nM。该化合物表现出抗精神病药物样的活性，并能有效抑制安非他明诱导的多动症。
T69595	Ispronicline hemigalactarate
	Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults.
T79784	VU6004909
	VU6004909为mGlu5受体正构效应调节剂，pEC50值为7.59。其具有抗精神病样效应，并能逆转MK801引起的皮质活动增强和认知功能障碍。
T79803	5-HT2C agonist-3 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2C agonist-3 ((+)-19) free base 是选择性的5-HT2C激动剂，具EC50: 24 nM及Ki: 78 nM值。该化合物展现出抗精神病药物样活性，并能阻断安非他明引起的多动症。
T34192	Pumiliotoxin C Decahydro-5-methyl-2-propylquinoline,5-Methyl-2-propyldecahydroquinoline
	Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs. There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting
T60369	Droxidopa hydrochloride
	Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压，改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压（nOH）和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...
T35560	SAR502250
	SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic...

化合物

Cat.No: TQ0046

Synonym: JNJ-31001074

Target: Histamine Receptor

CP-809101 hydrochloride

Cat.No: T10871

Target: 5-HT Receptor

Guanfacine hydrochloride

Cat.No: T2150

Synonym: 盐酸胍法辛,Tenex,Intuniv,Guanfacine

Target: Adrenergic Receptor

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

Cat.No: T60201

Target: GluR

Cat.No: T33816

Synonym: ACR-325,ACR 325,ACR325

Target: Dopamine Receptor

Tetrabenazine Metabolite

Cat.No: T13133

Synonym: (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ

Target: Monoamine Transporter

Cat.No: T12054L

Synonym: MK-0249 FA(862309-06-6 Free base)

Target: Histamine Receptor

Cat.No: T31604

Synonym: LY-2216684,LY 2216684,LY2216684

Cat.No: T14970

Synonym: GT-2331

Target: Others

Cat.No: T32224

Synonym: Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid

Cat.No: T10226

Synonym: ABT 894

Target: Others

Samelisant dihydrochloride

Cat.No: T34752

Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Edivoxetine hydrochloride

Cat.No: T61544

5-HT2C agonist-3

Cat.No: T79802

Target: 5-HT Receptor

Ispronicline hemigalactarate

Cat.No: T69595

Cat.No: T79784

5-HT2C agonist-3 free base

Cat.No: T79803

Target: 5-HT Receptor

Cat.No: T34192

Synonym: Decahydro-5-methyl-2-propylquinoline,5-Methyl-2-propyldecahydroquinoline

Droxidopa hydrochloride

Cat.No: T60369

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Cat.No: T35560

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