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Search Results for " hydroxysteroid "

40

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T76147	3α-Hydroxysteroid dehydrogenase
	3α-Hydroxysteroid dehydrogenase(3α-HSD) 是一种由 AKR1C4 基因编码的酶，可以催化 3-酮类甾体转化为 3α-羟基化合物。3α-Hydroxysteroid dehydrogenase 在雄激素 DHT 的失活中起重要作用，可以将 DHT 转化成雄激素活性很弱的 3α-雄烷二醇，可用于多毛症研究。
T0238	2-(Acetyloxy)-3-Methylbenzoic Acid	Others	Others
	2-(Acetyloxy)-3-Methylbenzoic Acid 用于 qHTS 测定羟基类固醇 (17-β) 脱氢酶 4、HSD17B4 的抑制剂，活性值为 19.95 μM。
T68664	Epostane Win-32729	Dehydrogenase	Metabolism
	Epostane (Win-32729) 是一种 3β- 羟基类固醇脱氢酶抑制剂，通过抑制 3β-羟类固醇脱氢酶发挥作用，阻断黄体酮的产生。
T67903	11β-HSD1 inibitor 17	Dehydrogenase	Metabolism
	11β-HSD1 inibitor 17 是11β-羟基类固醇脱氢酶（11β-HSD1）抑制剂。
T9594	BI-187004	Dehydrogenase	Metabolism
	BI-187004 是一种 11β-羟基类固醇脱氢酶 1 抑制剂。
T14151	AKR1C1-IN-1	NADPH	Metabolism
	AKR1C1-IN-1 是高选择性 AKR1C1抑制剂(Ki:4 nM)。
T14388	AZD 4017	Dehydrogenase	Metabolism
	AZD 4017 是高效的、选择性的11β-HSD1抑制剂，IC50为 7 nM。
T71394	BMS-823778
	BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is a potential therapeutic agent for type 2 diabetes mellitus (T2DM).
T3542	BVT-14225 BVT 14225	Dehydrogenase	Metabolism
	BVT-14225 是一种选择性的11β羟基类固醇脱氢酶1型(11β-HSD1)抑制剂(IC50:52 nM)。
T13100	TC HSD 21	Dehydrogenase	Metabolism
	TC HSD 21 是一种有效且高度选择性的 17β-羟基类固醇脱氢酶 3 型抑制剂 (IC50 = 14 nM)。
T77576	17β-HSD10-IN-1	Dehydrogenase; Endogenous Metabolite	Metabolism
	17β-HSD10-IN-1 是一种可口服且具有血脑通透性和有效性的 17β-羟基类固醇脱氢酶 10 型 (17β-HSD10) 抑制剂，可用于研究阿尔茨海默症。
T1473	Trilostane 曲洛斯坦,Win 24540,曲洛司坦	Dehydrogenase	Metabolism
	Trilostane (Win 24540) 是一种3 β-羟化类固醇脱氢酶抑制剂，能够作用于库兴氏综合征。
T73446	BI‑3231	Dehydrogenase	Metabolism
	BI‑3231 是一种具有选择性和高效性的羟基类固醇 17ß-脱氢酶 13 HSD17B13 抑制剂，抑制 hHSD17B13 和 mHSD17B13。BI‑3231 可用于研究酒精相关肝损伤、纤维化和肝硬化。
T77606	WAY-311610	Dehydrogenase	Metabolism
	WAY-311610是一种11β-羟基类固醇脱氢酶HSD11B1抑制剂，抑制11β-HSD1酶，IC = 0.34μM。可用于研究神经性疼痛、炎症性疼痛和枕神经痛。
T22458	WEHL-04 7-Bromo-1,2,3,4-tetrahydroquinoline,7-溴-1,2,3,4-四氢喹啉	Others	Others
	WEHL-04 是一种中间体，用于制备（异喹啉基磺酰基）苯甲酸，作为 5 型 71-β-羟基类固醇脱氢酶 AKR1C3 的抑制剂。它还用于合成 2-氨基八氢环戊二烯-3a-羧酰胺作为有效的 CCR2 拮抗剂。
T16510	PF-915275	Dehydrogenase	Metabolism
	PF-915275 是口服有效的人 11β-羟基类固醇脱氢酶1型选择性抑制剂，Ki 为 2.3 nM，在 HEK293 细胞中的EC50为 15 nM 。它对人和猴原代肝细胞中可的松向皮质醇的转化具有剂量依赖性，EC50分别为 20 nM 和 100 nM。
T63569	HSD-016
	HSD-016 是选择性的、有效的、口服具有活力的 1 型 11β-羟类固醇脱氢酶（11β-HSD1）抑制剂，能够作用于人 11β-HSD1 (IC50: 11 nM)、小鼠 11β-HSD1 (IC50: 1 nM)、大鼠 11β-HSD1 (IC50: 8 nM)。HSD-016 能够用于研究 2 型糖尿病。
T60149	11β-HSD1-IN-11	Dehydrogenase	Metabolism
	11β-HSD1-IN-11 是一种有效的、具有竞争性的 11- β-羟基类固醇脱氢酶1 (11β-HSD1)抑制剂，对大鼠和人的 11β-HSD1具有抑制作用，IC50 分别为 0.34 μM 和 0.13 μM。11β-HSD1- in -11是一种作为的化合物。11β-HSD1-IN-11是一种参与调节各种生理过程的激素，例如代谢、炎症和应激反应。11β-HSD1-IN-11是治疗代谢紊乱、肥胖和某些炎症状况的潜在化合物。
T26528	ABT-384
	ABT-384 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.
T28727	SCH-451659
	SCH-451659 is an 17β-hydroxysteroid dehydrogenases (17β-HSDs) inhibitor.
T33423	MK-0916 MK 0916
	MK-0916 is a 11β-hydroxysteroid dehydrogenase type 1 inhibitor indicated for the treatment of type 2 diabetes and metabolic syndrome as well as obesity-related diseases.
T81010	Tetrahydro-11-dehydrocorticosterone
	Tetrahydro-11-dehydrocorticosterone 是一种抑制11β-HSD（11β-羟类固醇脱氢酶）的化合物。
T28796	SKI2852 SK I2852,SKI-2852
	SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM.
T10946	D4-abiraterone Abiraterone D4A metabolite,CB-7627,Δ4-Abiraterone	Androgen Receptor	Endocrinology/Hormones
	D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.
T61716	Steroid sulfatase/17β-HSD1-IN-1
	Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of both steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, displaying an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1].
T79886	HSD17B13-IN-3
	HSD17B13-IN-3（化合物2）是一种有效的HSD17B13抑制剂，但不具备细胞实验活性。
T79885	HSD17B13-IN-2
	HSD17B13-IN-2（化合物1）是一种高效的HSD17B13抑制剂，显示出显著的细胞实验活性。
T72249	BMS-823778 hydrochloride
	BMS-823778 hydrochloride为一种高效、选择性的口服11β-HSD1抑制剂，其对人11β-HSD1的IC50值为2.3 nM。
T61593	11β-HSD1-IN-6
	11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs). These enzymes are responsible for catalyzing the conversion of the active glucocorticoids, corticosterone or cortisol, to their respective inactive forms, 11-dehydrocorticosterone (11-DHC) and cortisone. The compound 11β-HSD1-IN-6 specifically targets and inhibits 11β-HSD-1, effectively modulating the interconversion of these glucocorticoids. [1]
T80817	WAY-328127
	WAY-328127是一种活性分子，适用于生化反应研究。
T60203	INCB13739
	INCB13739是一种具有口服活性、高效、选择性及组织特异性的11β-HSD1抑制剂，对11β-HSD1酶的IC50为3.2 nM，对11β-HSD1 PBMC的IC50为1.1 nM。适用于2型糖尿病(T2DM)和肥胖的研究。
T35572	Adenosine 3',5'-diphosphate sodium salt 3'-Phosphoadenosine 5'-phosphate	Endogenous Metabolite	Metabolism
	Adenosine 3',5'-diphosphate sodium salt 是一种羟类固醇磺基转移酶 (hydroxysteroid sulfotransferases) 抑制剂，是一种腺嘌呤核苷酸，在戊糖核糖的 3'和 5'位置含有一个磷酸基团。Adenosine 3',5'-diphosphate (sodium salt)是 3'-phosphoadenosine 5'-phosphosulfonate (PAPS) 的产物，是磺基转移酶（SULTs）的辅助因子，已被用于研究 SULTs 的动力学特性和结构。
T12663	(Rac)-BMS-816336	Dehydrogenase	Metabolism
	(Rac)-BMS-816336 (Compound 6n) 是 BMS-816336 的外消旋体。(Rac)-BMS-816336 是人和小鼠 11β-羟类固醇脱氢酶 1 型 (11β-HSD1) 的有效抑制剂，其 IC50分别为 10 nM 和 68 nM，并具有良好的代谢稳定性。
T68808	11-Dehydrocorticosterone
	11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydro...
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 rever...
T79459	17β-HSD10-IN-2	Endogenous Metabolite	Metabolism
	17β-HSD10-IN-2（compound 11）是一款基于苯并噻唑脲结构的17β-羟基类固醇脱氢酶10型（17β-HSD10）抑制剂，后者为一种具有多功能性的线粒体酶。该抑制剂未触发线粒体脱靶现象，且不具备细胞毒性或神经毒性。17β-HSD10-IN-2可用于研究阿尔茨海默病（AD）和激素依赖型癌症。
T62236	Steroid sulfatase/17β-HSD1-IN-3
	Steroid sulfatase/17β-HSD1-IN-3 (compound 19) 是一种双重的类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 抑制剂。Steroid sulfatase/17β-HSD1-IN-3 对 hSTS 的活性具有不可逆的抑制作用 (IC50: 27 nM)。Steroid sulfatase/17β-HSD1-IN-3 能够用于研究子宫内膜异位症及其他雌激素依赖性疾病。
T61979	Steroid sulfatase/17β-HSD1-IN-4
	Steroid sulfatase/17β-HSD1-IN-4 (compound 37) 是一种类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 双重抑制剂。Steroid sulfatase/17β-HSD1-IN-4 对 hSTS 的活性抑制作用不可逆，IC50为 63 nM。Steroid sulfatase/17β-HSD1-IN-4 在子宫内膜异位症及其他雌激素依赖性疾病方面有研究价值。
T81092	Steroid sulfatase/17β-HSD1-IN-5
	Steroid sulfatase/17β-HSD1-IN-5 是一种不可逆抑制剂，针对类固醇硫酸酯酶(STS)，同时也是17β-羟甾类固醇脱氢酶1型(17β-HSD1)的可逆且选择性抑制剂，表现出对17β-HSD1的IC50为43 nM，对17β-HDS1为6.2 μM。该化合物主要用于研究代谢性疾病，特别是子宫内膜异位症。
T74729	18β-Glycyrrhetyl-3-O-sulfate
	18β-Glycyrrhetyl-3-O-sulfate（Glycyrrhetic acid 3-O-(hydrogen sulfate)）是一种对2型11β-羟基类固醇脱氢酶（11β-HSD2）具有高效抑制作用的化合物，其在大鼠肾微粒体中的IC50值为0.10 µM。作为Glycyrrhetinic acid (GA)的重要代谢产物，18β-Glycyrrhetyl-3-O-sulfate同时也是有机阴离子转运蛋白（OAT）1和OAT3的底物。此外，该化合物展示出抗炎活性，并可能用于假性醛固酮增多症的研究领域。

化合物

3α-Hydroxysteroid dehydrogenase

Cat.No: T76147

2-(Acetyloxy)-3-Methylbenzoic Acid

Cat.No: T0238

Target: Others

Cat.No: T68664

Synonym: Win-32729

Target: Dehydrogenase

11β-HSD1 inibitor 17

Cat.No: T67903

Target: Dehydrogenase

Cat.No: T9594

Target: Dehydrogenase

Cat.No: T14151

Target: NADPH

Cat.No: T14388

Target: Dehydrogenase

Cat.No: T71394

Cat.No: T3542

Synonym: BVT 14225

Target: Dehydrogenase

Cat.No: T13100

Target: Dehydrogenase

17β-HSD10-IN-1

Cat.No: T77576

Target: Dehydrogenase, Endogenous Metabolite

Cat.No: T1473

Synonym: 曲洛斯坦,Win 24540,曲洛司坦

Target: Dehydrogenase

Cat.No: T73446

Target: Dehydrogenase

Cat.No: T77606

Target: Dehydrogenase

Cat.No: T22458

Synonym: 7-Bromo-1,2,3,4-tetrahydroquinoline,7-溴-1,2,3,4-四氢喹啉

Target: Others

Cat.No: T16510

Target: Dehydrogenase

Cat.No: T63569

11β-HSD1-IN-11

Cat.No: T60149

Target: Dehydrogenase

Cat.No: T26528

Cat.No: T28727

Cat.No: T33423

Synonym: MK 0916

Tetrahydro-11-dehydrocorticosterone

Cat.No: T81010

Cat.No: T28796

Synonym: SK I2852,SKI-2852

Cat.No: T10946

Synonym: Abiraterone D4A metabolite,CB-7627,Δ4-Abiraterone

Target: Androgen Receptor

Steroid sulfatase/17β-HSD1-IN-1

Cat.No: T61716

Cat.No: T79886

Cat.No: T79885

BMS-823778 hydrochloride

Cat.No: T72249

Cat.No: T61593

Cat.No: T80817

Cat.No: T60203

Adenosine 3',5'-diphosphate sodium salt

Cat.No: T35572

Synonym: 3'-Phosphoadenosine 5'-phosphate

Target: Endogenous Metabolite

(Rac)-BMS-816336

Cat.No: T12663

Target: Dehydrogenase

11-Dehydrocorticosterone

Cat.No: T68808

Cat.No: T70763

17β-HSD10-IN-2

Cat.No: T79459

Target: Endogenous Metabolite

Steroid sulfatase/17β-HSD1-IN-3

Cat.No: T62236

Steroid sulfatase/17β-HSD1-IN-4

Cat.No: T61979

Steroid sulfatase/17β-HSD1-IN-5

Cat.No: T81092

18β-Glycyrrhetyl-3-O-sulfate

Cat.No: T74729

Cat. No.	Product Name	Target	Signaling Pathways
T2207	Adrenosterone 肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G	Androgen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Adrenosterone (11-ketoandrostenedione) 是一种人内源性代谢物，由肾上腺皮质产生。Adrenosterone 是一种竞争性羟基类固醇脱氢酶 1 抑制剂。它是一种的类固醇激素，具有较弱的雄激素特性。它是一种膳食补充剂，能够减少脂肪并提高肌肉质量。它能够抑制人类癌细胞的转移进展。
T14001	11-Beta-hydroxyandrostenedione 4-雄烯-11β-醇-3,17-二酮,NSC-17102,4-Androsten-11β-ol-3,17-dione	Endogenous Metabolite	Metabolism
	11-Beta-hydroxyandrostenedione (NSC-17102) 是主要存在于肾上腺的类固醇，也是 11β-羟基类固醇脱氢酶同工酶抑制剂。随着 4-androstenedione 的提高，通过测量血浆中的11-Beta-hydroxyandrostenedione，能够区分高雄激素血症的肾上腺或卵巢起源。
T0522	Diammonium Glycyrrhizinate 甘草酸二铵,Glycyrrhizin	Dehydrogenase	Metabolism
	Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物，有抗炎作用。
TJS0341	7-Amino-4-(trifluoromethyl)coumarin 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素	5-HT Receptor	GPCR/G Protein; Neuroscience
	7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) 是一种荧光标记物，其激发和发射波长分别为400和500 nm，可用来灵敏的检测蛋白酶。
T17057	Tetrahydrocortisol	Others	Others
	The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase activity. Tetrahydrocortisol is cortisol metabolite.
TN5230	Vibralactone D	Others	Others
	Vibralactones D shows weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
TCA2511	11Beta-hydroxyprogesterone	Sodium Channel	Membrane transporter/Ion channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
T83364	3-Acetyl-11-keto-ursolic acid
	3-Acetyl-11-keto-ursolic acid (Compound 18)为Eriobotrya japonica叶中提取的三萜类化合物，其抑制11b-羟基类固醇脱氢酶1 (11b-HSD1) 的特性使其在抗糖尿病研究中具有应用潜力。

天然产物

Cat.No: T2207

Synonym: 肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G

Target: Androgen Receptor, Endogenous Metabolite

11-Beta-hydroxyandrostenedione

Cat.No: T14001

Synonym: 4-雄烯-11β-醇-3,17-二酮,NSC-17102,4-Androsten-11β-ol-3,17-dione

Target: Endogenous Metabolite

Diammonium Glycyrrhizinate

Cat.No: T0522

Synonym: 甘草酸二铵,Glycyrrhizin

Target: Dehydrogenase

7-Amino-4-(trifluoromethyl)coumarin

Cat.No: TJS0341

Synonym: 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素

Target: 5-HT Receptor

Tetrahydrocortisol

Cat.No: T17057

Target: Others

Cat.No: TN5230

Target: Others

11Beta-hydroxyprogesterone

Cat.No: TCA2511

Target: Sodium Channel

3-Acetyl-11-keto-ursolic acid

Cat.No: T83364

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