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Search Results for " helicase "

47

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72107	Werner syndrome RecQ helicase-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Werner syndrome RecQ helicase-IN-1 是一种有效的 Werne r 综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用研究像结肠癌和胃癌等癌症。
T22980	MIRA-1 p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis; p53	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	MIRA-1 (WRN Helicase Inhibitor) 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。
T72108	Werner syndrome RecQ helicase-IN-2
	Werner syndrome RecQ helicase-IN-2 (example 57) 是一种有效的 Werner 综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用于癌症研究。
T72109	Werner syndrome RecQ helicase-IN-3
	Werner syndrome RecQ helicase-IN-3 是一种口服活性的 Werner 综合征 RecQ DNA 解旋酶 WRN 的有效抑制剂，其 IC50 值为 0.06 µM，展现出抗增殖和抗癌活性。
T72110	Werner syndrome RecQ helicase-IN-4
	Werner syndrome RecQ helicase-IN-4 是一种针对 Werner 综合征 RecQ DNA 解旋酶WRN 的有效口服WRN 抑制剂，其IC50值仅为 0.06 µM。该化合物表现出显著的抗增殖和抗癌活性。
T9168	NSC 617145 NSC617145,NSC-617145	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
T2504	Pritelivir 普瑞利韦,BAY 57-1293,AIC316	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Pritelivir (BAY 57-1293) 是一种病毒解旋酶-引物酶复合物抑制剂，有抗病毒活性。它对 HSV-1 和 HSV-2 具有活性，IC50值为 20 nM。
T5413	ML216 CID-49852229	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ML216 (CID-49852229) 是一种选择性、细胞渗透性的BLM 解旋酶抑制剂，具有抗肿瘤活性。它对BLMfull-length 和BLM636-1298的IC50分别为 2.98 μM 和 0.97 μM。
T22282	Brr2-IN-3 Brr2 Inhibitor 9,Brr2 Inhibitor C9	Others	Others
	Brr2-IN-3 (Brr2 Inhibitor C9) 是选择性 Brr2解旋酶变构抑制剂。它呈剂量依赖性地抑制解旋酶(IC50:1.3 μM)。
T16961	Supinoxin RX-5902	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂，是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长，IC50的范围为 10 nM 至 20 nM。
T4226	Amenamevir ASP2151,阿莫奈韦	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Amenamevir (ASP2151) 是一种新型解旋酶引发酶抑制剂，对水痘带状疱疹病毒和 1 型和 2 型单纯疱疹病毒具有活性，EC50值为 14 ng/mL。
T40823	NCGC00029283	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
T19073	Tris(4-aminophenyl)methane 4,4’,4"-三氨基三苯甲烷,Leucopararosaniline	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Tris(4-aminophenyl)methane (Leucopararosaniline) 是一种三苯甲烷类染料，是一种 HCV 解旋酶抑制剂。
T2275	YK-4-279 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂，能抑制ESFT 细胞增长，诱导凋亡。
T9678	ML328	Others	Others
	ML328 是一种有效的选择性细菌 AddAB(IC50 = 1.0 μM) 和 RecBCD(IC50 = 4.8 μM) 解旋酶核酸酶抑制剂。
T82568	DHX9-IN-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DHX9-IN-2 是一种针对ATP依赖型RNA解螺旋酶A(DHX9)的抑制剂，具有抗癌和抗肿瘤活性，可用于研究癌症。
T6970	RK33 RK-33,RK 33	COX	Immunology/Inflammation; Neuroscience
	RK33 (RK 33) 是 DDX3（一种 RNA 解旋酶）的一流小分子抑制剂，可导致 G1 细胞周期停滞，诱导细胞凋亡，并促进 DDX3 过表达细胞的辐射增敏。
T9679	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide	Antibacterial	Microbiology/Virology
	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide 对细菌 DNA 解旋酶、核酸酶或解旋酶-核酸酶复合物具有抑制作用，例如例如，一种或多种选自 RecBCD 和AddAB 酶家族的酶。
T15146	DNA2 inhibitor C5	Others	Others
	DNA2 inhibitor C5 是竞争性特异性的DNA2 核酸酶活性抑制剂(IC50:20 μM)。它能够抑制DNA 依赖性 ATPase、 DNA2 的核酸酶、解旋酶和 DNA 结合活性。它可用于研究奥正癌症。
T68815	NCGC00063279
	NCGC00063279 is a novel inhibitor of the werner syndrome helicase-nuclease (wrn) helicase
T30934	CID-50930756 CID 50930756,CID50930756
	CID-50930756 is a novel HCV NS3 helicase catalyzed ATP hydrolysis stimulator.
T40957	Adeninobananin
	Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase.
T40955	Vanillinbananin
	Vanillinbananin is a potent inhibitor of SARS Coronavirus helicase ATPase activity, displaying an IC50 value of 0.68 μM.
T39828	BPK-21
	BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.
T40767	Bananin
	Bananin, a potent inhibitor of the ATPase activity exhibited by the SARS Coronavirus helicase, demonstrates remarkable efficacy with an IC50 value of 2.3 μM.
T79107	WRN inhibitor 1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	WRN inhibitor 1 (example 7) 为一Werner 综合征 ATP 依赖性解旋酶WRN抑制剂，能有效抑制WRN解旋酶结构域的活性，呈现出潜在的抗癌研究价值。
T40956	Eubananin
	Eubananin effectively inhibits the ATPase activity of the SARS Coronavirus helicase, displaying an IC50 value of 2.8 μM.
T40954	Iodobananin
	Iodobananin effectively inhibits the ATPase activity of the SARS Coronavirus helicase, displaying an IC 50 value of 0.54 μM.
T61285	FWM-3
	FWM-3是一种有效的 SARS-CoV-2 NSP13解旋酶抑制剂。
T78938	H3B-968	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	H3B-968为一种高效Werner综合征蛋白(WRN)抑制剂，IC50约为10 nM，可抑制具有解旋酶、ATP酶和外切酶活性的WRN。WRN在癌症研究中具有显著的合成致死潜力。H3B-968通过与ATP竞争抑制WRN解旋酶活性。
T10848	CMLD012073	Others	Others
	CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
T16575	Pritelivir mesylate hydrate BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate	Others	Others
	Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vit
T81967	KY386
	KY386为选择性DHX33 helicase抑制剂，IC50仅19 nM。针对U251-MG细胞（DHX33过表达癌细胞株）的抑制作用表现出相似效力，IC50为20 nM。该化合物展现出显著的抗癌活性及中等的代谢稳定性。
T61523	FWM-5
	FWM-5 is a powerful inhibitor of NSP13 helicase, a key enzyme in the life cycle of the SARS-CoV-2 virus. With its potential in researching infectious diseases, FWM-5 emerges as a promising compound [1].
T82569	DHX9-IN-1
	DHX9-IN-1，作为ATP依赖性RNA解螺旋酶A (DHX9) 的抑制剂，表现出9.45 nM的IC50值，并具有抗肿瘤活性。
T16576	Pritelivir mesylate BAY 57-1293 mesylate,AIC316 mesylate	Others	Others
	Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models
T74377	Ansabananin
	Ansabananin 是一种 SARS 病毒解旋酶 ATP 酶活性的抑制剂，其IC50为 51 μM。
T80772	WRN inhibitor 5
	WRN inhibitor 5（例157）为环状乙烯基砜化合物，充当韦默综合征ATP依赖性解旋酶（WRN）的抑制剂，适用于癌症研究领域。
T79178	WRN inhibitor 2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	WRN inhibitor 2 (example 118)为一WRN（Werner综合征ATP依赖性解旋酶）的抑制剂，其pIC50值不小于7.0。
T36748	Heliquinomycin
	Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, resp...
T62031	SARS-CoV-2 nsp13-IN-4
	SARS-CoV-2 nsp13-IN -4 (C4 (d)) 是强效的、选择性的 nsp13 helicase 小分子抑制剂。SARS-CoV-2 nsp13-IN -4 抑制 nsp13 的 ssDNA+ ATPase 活性，IC50值为57 μM。SARS-CoV-2 nsp13-IN-4 显示广谱抗病毒作用。
T80773	WRN inhibitor 4
	WRN inhibitor 4 (example 107)，环状乙烯基砜类化合物，作为Werner综合症ATP依赖性解旋酶（WRN）的抑制剂，适用于癌症研究领域。
T68091	ledoxantrone
	Ledoxantrone 是一种新型化学类苯并吡喃吲哚类的合成插层剂，具有良好的临床前活性。其作用机制被认为是稳定DNA 与拓扑异构酶II 的可切割复合物，以及阻断DNA 解旋酶。
T80774	WRN inhibitor 3
	WRN inhibitor 3（示例110），一种选择性韦默综合征ATP依赖性解旋酶(WRN)抑制剂，具有环状乙烯基砜结构。本化合物在癌症研究中具有潜在应用价值。
T75028	TMV-IN-4
	TMV-IN-4（compound 3）是一种针对烟草花叶病毒（TMV）的抑制剂。该化合物通过与TMV解旋酶交互作用，能够诱导植物产生抗性并提高对TMV感染的耐受性。TMV-IN-4还可增强过氧化物酶和超氧化物歧化酶活性，从而提升烟草的TMV抗性。
T13817L	Phen-DC3 Trifluoromethanesulfonate Phen-DC3 Triflate	Others	Others
	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).
T13817	Phen-DC3	Others	Others
	Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases (IC50s of 65±6 and 50±10 nM, respectively).

化合物

Werner syndrome RecQ helicase-IN-1

Cat.No: T72107

Target: DNA/RNA Synthesis

Cat.No: T22980

Synonym: p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor

Target: DNA/RNA Synthesis, p53

Werner syndrome RecQ helicase-IN-2

Cat.No: T72108

Werner syndrome RecQ helicase-IN-3

Cat.No: T72109

Werner syndrome RecQ helicase-IN-4

Cat.No: T72110

Cat.No: T9168

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

Cat.No: T2504

Synonym: 普瑞利韦,BAY 57-1293,AIC316

Target: DNA/RNA Synthesis, HSV

Cat.No: T5413

Synonym: CID-49852229

Target: DNA/RNA Synthesis

Cat.No: T22282

Synonym: Brr2 Inhibitor 9,Brr2 Inhibitor C9

Target: Others

Cat.No: T16961

Synonym: RX-5902

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T4226

Synonym: ASP2151,阿莫奈韦

Target: DNA/RNA Synthesis, HSV

Cat.No: T40823

Target: DNA/RNA Synthesis

Tris(4-aminophenyl)methane

Cat.No: T19073

Synonym: 4,4’,4"-三氨基三苯甲烷,Leucopararosaniline

Target: HCV Protease

Cat.No: T2275

Synonym: 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T9678

Target: Others

Cat.No: T82568

Target: DNA/RNA Synthesis

Cat.No: T6970

Synonym: RK-33,RK 33

Target: COX

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide

Cat.No: T9679

Target: Antibacterial

DNA2 inhibitor C5

Cat.No: T15146

Target: Others

Cat.No: T68815

Cat.No: T30934

Synonym: CID 50930756,CID50930756

Cat.No: T40957

Vanillinbananin

Cat.No: T40955

Cat.No: T39828

Cat.No: T40767

WRN inhibitor 1

Cat.No: T79107

Target: DNA/RNA Synthesis

Cat.No: T40956

Cat.No: T40954

Cat.No: T61285

Cat.No: T78938

Target: DNA/RNA Synthesis

Cat.No: T10848

Target: Others

Pritelivir mesylate hydrate

Cat.No: T16575

Synonym: BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate

Target: Others

Cat.No: T81967

Cat.No: T61523

Cat.No: T82569

Pritelivir mesylate

Cat.No: T16576

Synonym: BAY 57-1293 mesylate,AIC316 mesylate

Target: Others

Cat.No: T74377

WRN inhibitor 5

Cat.No: T80772

WRN inhibitor 2

Cat.No: T79178

Target: DNA/RNA Synthesis

Cat.No: T36748

SARS-CoV-2 nsp13-IN-4

Cat.No: T62031

WRN inhibitor 4

Cat.No: T80773

Cat.No: T68091

WRN inhibitor 3

Cat.No: T80774

Cat.No: T75028

Phen-DC3 Trifluoromethanesulfonate

Cat.No: T13817L

Synonym: Phen-DC3 Triflate

Target: Others

Cat.No: T13817

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TJS0368	4-Phenyl-7,8-dihydroxycoumarin 7,8-二羟基-4-苯基香豆素,7,8-Dihydroxy-4-Phenyl-2H-Chromen-2-One,7,8-Dihydroxy-4-phenylcoumarin	Others	Others
	4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) 是香豆素衍生物，可用于研究支气管扩张。
TN1033	Sennidin A	HCV Protease; transporter; Akt; PI3K	Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Sennidin A 是从狭叶番泻分离得到的一种天然产物，能够抑制 HCV NS3 解旋酶，其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化，刺激葡萄糖掺入。

天然产物

4-Phenyl-7,8-dihydroxycoumarin

Cat.No: TJS0368

Synonym: 7,8-二羟基-4-苯基香豆素,7,8-Dihydroxy-4-Phenyl-2H-Chromen-2-One,7,8-Dihydroxy-4-phenylcoumarin

Target: Others

Cat.No: TN1033

Target: HCV Protease, transporter, Akt, PI3K

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