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Search Results for " hedgehog pathway inhibitor "

23

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T3156	Ciliobrevin A Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Ciliobrevin A (HPI-4) 是Hedgehog(Hh) 信号通路抑制剂，平均抑制浓度 (IC50) 值小于 10 μM。
T20723	LGE-899 Sonidegib metabolite M48,LGE 899	Drug Metabolite	Metabolism
	LGE-899 (Sonidegib metabolite M48) 是 Sonidegib 的主要代谢物，是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。
T3588	JK184	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	JK184 是 Hedgehog 抑制剂，在哺乳动物细胞中的IC50值为 30 nM。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
T22089	HPI 1	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活（Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM） .
T15019L	CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM)，可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。
T6891	MK-4101	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	MK-4101 是一种 SMO 拮抗剂，对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂，对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤，抑制肿瘤细胞增殖并诱导细胞凋亡。
T2590	Vismodegib Erivedge,GDC-0449,RG 3616,维莫德吉	Hedgehog/Smoothened; ABC; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Vismodegib (GDC-0449) 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制 P-gp 和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
T12797	RU-SKI 43 RUSKI 43	Hedgehog/Smoothened; Acyltransferase	GPCR/G Protein; Metabolism; Stem Cells
	RU-SKI 43 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂，IC50 为 850 nM。RU-SKI 43 具有抗癌活性，是治疗肺腺癌的潜在化合物。RU-SKI 43 通过独立于平滑化的非规范信号传导降低 Gli-1 激活，并抑制 Akt 和 mTOR 通路活性。
T5465	PF-5274857 PF-5274857 freebase	Smo	Stem Cells
	PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂，其 IC50=5.8 nM，Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。
T71299	M-25
	M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T75148	Hedgehog IN-3
	HedgehogIN-3 (化合物 3) 是一种hedgehog 通路抑制剂 (IC50= 0.01 µM)。HedgehogIN-3 可用于癌症的研究。
T16843	Saridegib IPI-926,Patidegib	Others	Others
	Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.
T71455	Glasdegib hydrochloride
	Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
T79055	Hedgehog IN-2
	HedgehogIN-2 (Compound 20)为一Hedgehog信号通路抑制剂，其在C3H10T1/2细胞中表现出低于0.003 μM的IC50值。
T15019	CUR61414	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM)，并选择性地结合 smoothened (Ki = 44 nM)。
T71338	Patidegib HCl
	Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligan...
T28388	PF-5274857 mseylate (1373615-35-0 free base) PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate
	PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mic
T79907	HPP-9
	HPP-9为一种蛋白降解靶向嵌合体(PROTACs)，基于Hedgehog通路抑制剂(HPI-1)开发，pIC50值为6.71，能够降解BET溴结构域，并表现出抗肿瘤活性[1]。
T70195	NL-103
	NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly dow...
T63387	SMO-IN-3
	SMO-IN-3 是 smoothened (SMO) 对有效抑制剂，能够作用于 hedgehog (Hh) 信号通路 (IC50: 34.09 nM)。SMO-IN-3 能够抑制人髓母细胞瘤细胞系 Daoy 的增殖，表现出抗癌作用。
T72726	3-epi-Vitamin D3 Epicholecalciferol
	3-epi-Vitamin D3 (Epicholecalciferol) 是维生素 D3 类似物，是一种Hedgehogpathway 抑制剂，在U87MG 细胞中测定的IC50为 39.2 μM。
T35538	HPI-1 (hydrate) HPI-1 hydrate
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...

化合物

Cat.No: T3156

Synonym: Hedgehog Pathway Inhibitor 4,HPI-4

Target: Hedgehog/Smoothened

Cat.No: T20723

Synonym: Sonidegib metabolite M48,LGE 899

Target: Drug Metabolite

Cat.No: T3588

Target: Hedgehog/Smoothened

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Cat.No: T22089

Target: Hedgehog/Smoothened

CUR61414 hydrochloride

Cat.No: T15019L

Synonym: CUR61414 hydrochloride (334998-36-6 Free base)

Target: Hedgehog/Smoothened

Cat.No: T6891

Target: Apoptosis, Hedgehog/Smoothened, Smo

Cat.No: T2590

Synonym: Erivedge,GDC-0449,RG 3616,维莫德吉

Target: Hedgehog/Smoothened, ABC, Autophagy

Cat.No: T12797

Synonym: RUSKI 43

Target: Hedgehog/Smoothened, Acyltransferase

Cat.No: T5465

Synonym: PF-5274857 freebase

Target: Smo

Cat.No: T71299

Hedgehog IN-3

Cat.No: T75148

Cat.No: T16843

Synonym: IPI-926,Patidegib

Target: Others

Glasdegib hydrochloride

Cat.No: T71455

Hedgehog IN-2

Cat.No: T79055

Cat.No: T15019

Target: Hedgehog/Smoothened

Cat.No: T71338

PF-5274857 mseylate (1373615-35-0 free base)

Cat.No: T28388

Synonym: PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate

Cat.No: T79907

Cat.No: T70195

Cat.No: T63387

3-epi-Vitamin D3

Cat.No: T72726

Synonym: Epicholecalciferol

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Cat. No.	Product Name	Target	Signaling Pathways
T3912	Saikosaponin B1 柴胡皂苷B1,柴胡皂苷 B1	Others	Others
	Saikosaponin B1 是柴胡的生物活性成分，具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路，显著抑制髓母细胞瘤模型中的肿瘤生长。

天然产物

Saikosaponin B1

Cat.No: T3912

Synonym: 柴胡皂苷B1,柴胡皂苷 B1

Target: Others

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