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Search Results for " fibrinogen "

49

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
TP1736L	Fibrinogen-Binding Peptide fb-acetate Fibrinogen-Binding Peptide （137235-80-4 fb-acetate)	Others	Others
	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集，还抑制血小板与玻连蛋白的粘附
TP1736	Fibrinogen-Binding Peptide
	Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, is a cofactor in platelet activation. It is converted
TP1778	Fibrinogen Binding Inhibitor Peptide
	Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411).
T78367	Fibrinogen (Bovine)
	Fibrinogen (Bovine)为特异性蛋白质水解酶，通过凝血酶激活过程组装成纤维蛋白凝块。
T80683	γ-Fibrinogen 377-395
	γ-Fibrinogen377-395是一种衍自纤维蛋白原的抑制性肽段，也被认为是纤维蛋白原的表位之一。它能在体外抑制小胶质细胞的激活并阻断纤维蛋白与Mac-1的交互作用；此外，在小鼠体内能够抑制实验性自身免疫性脑脊髓炎(EAE)的发展。因此，γ-Fibrinogen377-395对于多发性硬化症(MS)以及其他与血脑屏障损伤和小胶质细胞活化相关的神经炎症性疾病的研究具有潜在的应用价值。
T80682	γ-Fibrinogen 377-395 TFA
	γ-Fibrinogen377-395 TFA 是纤维蛋白原衍生抑制肽，具有纤维蛋白原表位特性。该化合物能在体外抑制小胶质细胞激活、阻断纤维蛋白与Mac-1相互作用，并在小鼠体内抑制实验性自身免疫性脑脊髓炎(EAE)。该肽适用于多发性硬化症(MS)及其他血脑屏障损伤和小胶质细胞激活相关的神经炎症疾病研究。
TP1060	GPRP acetate (67869-62-9 free base) Pefabloc FG,Pefa 6003,GPRP acetate	Others	Others
	GPRP acetate (Pefabloc FG) 是纤维蛋白聚合抑制剂，可抑制纤维蛋白原与血小板膜糖蛋白 Ⅱb/IIIa 复合物(糖蛋白 IIb/IIIa 受体)之间的相互作用。
T40711	H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride	Others	Others
	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation.
T12857	SC-52012	Others	Others
	SC-52012 是一种新型有效的纤维蛋白原受体 (fibrinogen receptor) 拮抗剂，是一种 RGD 模拟物，对血小板聚集有抑制作用。
T3638	Leukadherin-1	Integrin; Complement System	Cytoskeletal Signaling; Immunology/Inflammation
	Leukadherin-1 是 CD11b/CD18 的变构激活剂，可增加 CD11b/CD18 依赖性细胞对纤维蛋白原的粘附，减少白细胞运动和跨内皮迁移，具有抗炎作用。
TP1143L	Fibrinopeptide A, human acetate Fibrinopeptide A, human acetate(25422-31-5 free base),Human fibrinopeptide A acetate	Others	Others
	Fibrinopeptide A, human acetate (Human fibrinopeptide A acetate)(25422-31-5 free base) 是一种 16 个残基的短多肽，由凝血酶从纤维蛋白原上切割下来。纤维蛋白肽 A (FPA) 由纤维蛋白原蛋白的 N 末端 Aα 区域在被凝血酶切割后产生。
T5519	Bivalirudin BG-8967,比伐卢定,Hirulog-1	Thrombin	Proteases/Proteasome
	Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂，是一种肽类抗凝剂，可在侵入性心脏病，特别是在经皮冠状动脉介入中用于抗凝。
TP1458L	Arg-Gly-Glu-Ser acetate(93674-97-6 free base)	Others	Others
	Arg-Gly-Glu-Ser acetate(93674-97-6 free base) 是一种 RGD 相关肽，可控制纤维蛋白原与活化血小板结合的 RGDS 活性。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
TP1447L1	Arg-Gly-Asp-Cys acetate Arg-Gly-Asp-Cys acetate(109292-46-8 free base),RGDC acetate	Others	Others
	Arg-Gly-Asp-Cys acetate 抑制血小板聚集和纤维蛋白原结合。 Arg-Gly-Asp-Cys acetate 是纤连蛋白与细胞粘附分子的结合基序。
T26629	Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1	Metabolism
	Angstrom6 (A-6 peptide) 是一种从单链尿激酶纤溶酶原激活剂(scuPA)中提取的 8 肽，它能干扰 uPA/uPAR 级联反应并抑制下游效应。Angstrom6 具有抗肿瘤活性，能通过与 CD44 结合并调节 CD44 介导的细胞信号传导，抑制肿瘤细胞的迁移、侵袭和转移。
T24347	L 703014 L 703,014,L-703014,L703,014,L-703,014,L703014
	L 703014 is an antagonist of the fibrinogen receptor.
T24290	L 366763 L366,763,L-366,763,L-366763,L366763,L 366,763
	L 366763 is an antagonist of the peptidyl fibrinogen receptor.
T25460	GR 83895 GR-83895,GR83895
	GR 83895 is an antagonist of prototype fibrinogen receptor.
T24363	L 767679 L-767679,L767679
	L 767679 is an antagonist of the fibrinogen receptors.
T24352	L 734217 L-734,217,L-734217,L734217,L734,217,L 734,217
	L 734217 is an antagonist of the fibrinogen receptor.
T25608	Lamifiban trifluoroacetate Lamifiban trifluoroacetate salt
	Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).
T27419	GPRP Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt
	Gly-Pro-Arg-Pro Acetate, an inhibitor of fibrinogen aggregation, acts by binding to fibrinopeptide A.
TP1162	Fibrinopeptide B, human TFA (36204-23-6 free base) FPB,human TFA,Fibrinopeptide B, human TFA
	FibrinopeptideB,human is a 14-amino acid polypeptide released from the amino terminus of the fibrinogen segment.
T24743	RU-505 RU 505,RU505
	RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.
TP1142	Fibrinopeptide A, human TFA Human fibrinopeptide A TFA
	Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which b
T22807	GR 144053 trihydrochloride	Others	Others
	platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist
T24353	L 738167 L-738167,L738167
	L 738167 is a potent antagonist of the long-acting fibrinogen receptor.
TP1163	Fibrinopeptide B, human FPB,human
	Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.
TP1143	Fibrinopeptide A, human Human fibrinopeptide A
	Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A (FPA) is produced from the N-terminal Aα region of fibrinogen protein, on cleavage by thrombin.
TP1447	Arg-Gly-Asp-Cys RGDC
	Arg-Gly-Asp-Cys is the binding motif of fibronectin and cell adhesion molecules, which can inhibit platelet aggregation and fibrinogen binding.
TP1801	pGlu-Pro-Arg-MNA monoacetate
	pGlu-Pro-Arg-MNA monoacetate is a thrombin substrate which has been modeled after a thrombin cleavage site in human fibrinogen, can be used for a sensitive assay of antithrombin III activity.
T82063	Integrin signaling inhibitor, mP13
	Integrinsignaling inhibitor, mP13 是抑制整合素信号传导，阻止内向外和外向内信号传递，涉及纤维蛋白原结合、血小板粘附及凝块收缩的化合物。
T39655	Arg-Gly-Asp-Cys TFA
	Arg-Gly-Asp-Cys TFA serves as the binding motif through which fibronectin interacts with cell adhesion molecules. This compound has the ability to hinder platelet aggregation and fibrinogen binding.
TP1864	[Glu1]-Fibrinopeptide B [Glu1]-纤维蛋白肽B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts.
TP1458	Arg-Gly-Glu-Ser
	Arg-Gly-Glu-Ser is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets.
T39066	H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride,H-D-Phe-Pip-Arg-pNA hydrochloride
	H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, mimics the N-terminal segment of the A alpha chain of fibrinogen, the native substrate of thrombin. It displays specificity towards thrombin and is employed for quantifying antithrombin-heparin cofactor (AT-III). The utilization of H-D-Phe-Pip-Arg-pNA hydrochloride in the AT-III assay enables a sensitive, accurate, and straightforward measurement process.
TP1355	Arg-Gly-Glu-Ser(TFA)(93674-97-6,free) Arg-Gly-Glu-Ser(TFA)
	Arg-gly-glu -Ser(TFA) is a RGD related polypeptide that controls the inhibition of fibrinogen binding to activated platelets by RGDS.
T35582	H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)
	H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection ...
T81985	K-Casein (106-116),bovine
	K-Casein (106-116), bovine，为一抗血小板聚集与纤维蛋白原结合的多肽，动脉粥样硬化关键作用因子。
T76376	Lys-Gln-Ala-Gly-Asp-Val
	Lys-Gln-Ala-Gly-Asp-Val (KQAGDV), 纤维蛋白原γ链(fibrinogen γ-chain)末端六个氨基酸组成，是细胞粘附肽。通过α2bβ3整合素，介导细胞粘附，对平滑肌细胞(SMCs)具有有效粘附配体功能。
T78001	Arg-Gly-Glu-Ser TFA
	Arg-Gly-Glu-Ser TFA，作为RGD相关多肽，调节RGDS对纤维蛋白原及活化血小板结合的抑制作用。
T38542	H-D-Phe-Pip-Arg-pNA acetate H-D-Phe-Pip-Arg-pNA acetate,S-2238 acetate
	H-D-Phe-Pip-Arg-pNA (S-2238) acetate is a chromogenic substrate designed based on the N-terminal fragment of the A alpha chain of fibrinogen, which is the physiological target of thrombin. As a specific indicator of thrombin activity, H-D-Phe-Pip-Arg-pNA acetate is utilized to quantify. This assay, utilizing H-D-Phe-Pip-Arg-pNA acetate, ensures high sensitivity, accuracy, and ease of execution.
T64287	Reteplase
	Reteplase (BM 06.022) 是一种重组纤溶酶原 (plasminogen) 激活剂，由人组织型纤溶酶原激活剂的 kringle 2 和蛋白酶结构域构成。Reteplase 能够将纤溶酶原转化为纤溶酶，促使血栓溶解。Reteplase 通过 DNA 技术在大肠杆菌中产生的 t-PA 突变体，未糖基化。
T62731	ZK824190 hydrochloride
	ZK824190 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，能够作用于 uPA (IC50: 237 nM)、tPA (IC50: 1600 nM) 和 Plasmin (IC50: 1850 nM)。ZK824190 hydrochloride 能够用于研究多发性硬化症的研究
T62961	ZK824859 hydrochloride
	ZK824859 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。ZK824859 hydrochloride 对人 uPA，tPA 和纤溶酶的 IC50 值分别为 79 nM，1580 nM 和 1330 nM。
T74840	ERRγ agonist-2
	ERRγagonist-2 是一种有效的选择性 ERRγ反向激动剂，Kd 值为 6.5 μM。ERRγagonist-2 抑制铁调素、纤维蛋白原和糖异生基因的表达。ERRγagonist-2 具有抗菌、抗凝血和抗糖尿病活性。
TP2234	coagulation factor II (thrombin) B chain fragment [Homo sapiens]	Others	Others
	Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble
T83736	RTDLDSLRTYTL TFA
	RTDLDSLRTYTL是一种αVβ6整合素配体。它选择性地抑制纤维连接蛋白与αVβ6整合素的结合，相比之下，对于纤维连接蛋白与αVβ3或αVβ5以及纤维蛋白原与αIIβ3的结合则几乎不产生影响（IC50分别为0.02, >50, >50, 和 >50 µM）。此外，RTDLDSLRTYTL还能以浓度依赖的方式抑制HT-29结肠癌细胞与纤维连接蛋白的结合。

化合物

Fibrinogen-Binding Peptide fb-acetate

Cat.No: TP1736L

Synonym: Fibrinogen-Binding Peptide （137235-80-4 fb-acetate)

Target: Others

Fibrinogen-Binding Peptide

Cat.No: TP1736

Fibrinogen Binding Inhibitor Peptide

Cat.No: TP1778

Fibrinogen (Bovine)

Cat.No: T78367

γ-Fibrinogen 377-395

Cat.No: T80683

γ-Fibrinogen 377-395 TFA

Cat.No: T80682

GPRP acetate (67869-62-9 free base)

Cat.No: TP1060

Synonym: Pefabloc FG,Pefa 6003,GPRP acetate

Target: Others

H-D-Phe-Pip-Arg-pNA dihydrochloride

Cat.No: T40711

Synonym: S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride

Target: Others

Cat.No: T12857

Target: Others

Cat.No: T3638

Target: Integrin, Complement System

Fibrinopeptide A, human acetate

Cat.No: TP1143L

Synonym: Fibrinopeptide A, human acetate(25422-31-5 free base),Human fibrinopeptide A acetate

Target: Others

Cat.No: T5519

Synonym: BG-8967,比伐卢定,Hirulog-1

Target: Thrombin

Arg-Gly-Glu-Ser acetate(93674-97-6 free base)

Cat.No: TP1458L

Target: Others

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

Arg-Gly-Asp-Cys acetate

Cat.No: TP1447L1

Synonym: Arg-Gly-Asp-Cys acetate(109292-46-8 free base),RGDC acetate

Target: Others

Cat.No: T26629

Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide

Target: PAI-1

Cat.No: T24347

Synonym: L 703,014,L-703014,L703,014,L-703,014,L703014

Cat.No: T24290

Synonym: L366,763,L-366,763,L-366763,L366763,L 366,763

Cat.No: T25460

Synonym: GR-83895,GR83895

Cat.No: T24363

Synonym: L-767679,L767679

Cat.No: T24352

Synonym: L-734,217,L-734217,L734217,L734,217,L 734,217

Lamifiban trifluoroacetate

Cat.No: T25608

Synonym: Lamifiban trifluoroacetate salt

Cat.No: T27419

Synonym: Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt

Fibrinopeptide B, human TFA (36204-23-6 free base)

Cat.No: TP1162

Synonym: FPB,human TFA,Fibrinopeptide B, human TFA

Cat.No: T24743

Synonym: RU 505,RU505

Fibrinopeptide A, human TFA

Cat.No: TP1142

Synonym: Human fibrinopeptide A TFA

GR 144053 trihydrochloride

Cat.No: T22807

Target: Others

Cat.No: T24353

Synonym: L-738167,L738167

Fibrinopeptide B, human

Cat.No: TP1163

Synonym: FPB,human

Fibrinopeptide A, human

Cat.No: TP1143

Synonym: Human fibrinopeptide A

Arg-Gly-Asp-Cys

Cat.No: TP1447

Synonym: RGDC

pGlu-Pro-Arg-MNA monoacetate

Cat.No: TP1801

Integrin signaling inhibitor, mP13

Cat.No: T82063

Arg-Gly-Asp-Cys TFA

Cat.No: T39655

[Glu1]-Fibrinopeptide B

Cat.No: TP1864

Synonym: [Glu1]-纤维蛋白肽B

Arg-Gly-Glu-Ser

Cat.No: TP1458

H-D-Phe-Pip-Arg-pNA hydrochloride

Cat.No: T39066

Synonym: S-2238 hydrochloride,H-D-Phe-Pip-Arg-pNA hydrochloride

Arg-Gly-Glu-Ser(TFA)(93674-97-6,free)

Cat.No: TP1355

Synonym: Arg-Gly-Glu-Ser(TFA)

H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

Cat.No: T35582

K-Casein (106-116),bovine

Cat.No: T81985

Lys-Gln-Ala-Gly-Asp-Val

Cat.No: T76376

Arg-Gly-Glu-Ser TFA

Cat.No: T78001

H-D-Phe-Pip-Arg-pNA acetate

Cat.No: T38542

Synonym: H-D-Phe-Pip-Arg-pNA acetate,S-2238 acetate

Cat.No: T64287

ZK824190 hydrochloride

Cat.No: T62731

ZK824859 hydrochloride

Cat.No: T62961

ERRγ agonist-2

Cat.No: T74840

coagulation factor II (thrombin) B chain fragment [Homo sapiens]

Cat.No: TP2234

Target: Others

RTDLDSLRTYTL TFA

Cat.No: T83736

Cat. No.	Product Name	Target	Signaling Pathways
T3793	(20R)-Ginsenoside Rh1 20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1	Others	Others
	(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) 是 Ginsenoside Rh1 的 R 型异构体，分离自 Panax Ginseng 中，能够阻碍凝血酶诱导的纤维蛋白原向纤维蛋白的转化。
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...

天然产物

(20R)-Ginsenoside Rh1

Cat.No: T3793

Synonym: 20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1

Target: Others

Cat.No: TN5221

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