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18

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0787	Butylhydroxyanisole BHA,丁基羟基茴香醚,丁基大茴香醚,E320,Butylated hydroxyanisole	Antioxidant; Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Butylhydroxyanisole (BHA) 是一种抗氧化剂，能介导肝毒性、生殖器官发育和学习迟缓以及睡眠不足，用作食品防腐剂。它也是一种铁死亡诱导剂，能导致大脑和神经发育中断，具有神经毒性。
T13807	OSIP-486823 CP248	Microtubule Associated; PKA	Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	OSIP-486823（CP248）是一种新型有效的微管干扰剂，对蛋白激酶 G (PKG) 和微管均具有亲和力。
TQ0055	AMG-3969	Glucokinase	Metabolism
	AMG-3969 是一种葡萄糖激酶-葡糖激酶调节蛋白相互作用的干扰物，IC50=为4 nM。
T5626	Atrazine Aktikon,Chromozin,Gesaprim,莠去津,Oleogesaprim,阿特拉津	Others	Others
	Atrazine (Oleogesaprim) 能够抑制光磷酸化，但通不会在短期内导致致命性或永久性细胞损伤，常用于控制一年生阔叶杂草。
T72049	4-N-Nonyloxyphenol 4-nonoxyphenol,p-Nonyloxyphenol
	4-N-Nonyloxyphenol (4-nonoxyphenol) 是一种基于高岭土纳米管的杂化光敏剂，是一种广泛使用的农药和内分泌干扰剂，可用于苯酚基农药的光降解。
T9093	NY2267 Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester	c-Myc	Cell Cycle/Checkpoint
	NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester) 是一种 Myc-Max 相互作用干扰物，抑制 Myc 和 Jun 诱导的转录激活，其 IC50值为 36.5 μM。
T2060	ELR510444 LR-510444,LR510444,LR 510444	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	ELR510444 (LR510444) 是一种新型微管破坏剂，抑制 MDA-MB-231 细胞增殖，IC50 为 30.9 nM。
T9118	KEA1-97	Apoptosis; Others; Caspase	Apoptosis; Others; Proteases/Proteasome
	KEA1-97 是一种选择性硫氧还蛋白-半胱天冬酶 3相互作用干扰剂，IC50为10 μM。它在不影响硫氧还蛋白活性的情况下, 破坏硫氧还蛋白与 caspase 3 的相互作用，激活半胱天冬酶，诱导细胞凋亡。
T14212	AMG-1694	Glucokinase	Metabolism
	AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白（GK-GKRP）干扰物，能促进 GK-GKRP 复合物的解离，其 IC50 值为 7 nM，从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常，并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GKRP 对 GK 活性的抑制作用，并促进 GK 转位。
T34858	THIQ-20c THIQ 20c
	THIQ-20c is a steroidomimetic and chimeric microtubule disruptor.
T34711	STAD 2 STAD-2,STAD2
	STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap
T13725	Hsp90-Cdc37-IN-1	Others	Others
	Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.
T68528	M-COPA
	M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear factor-kappaB (NF-kappaB) signaling pathways.
T38379	4-tert-Octylphenol diethoxylate
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.
TP2129	RI-STAD 2
	AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.
T60539	KG-548
	KG-548 是一种ARNT/TACC3干扰剂以及HIF-1α抑制剂。KG-548 通过 ARNT 的 PAS-B 结构域与 TACC3 竞争性结合，直接干扰ARNT/TACC3复合物的形成。ARNT 是芳基烃受体核转运蛋白，也称为 HIF-β。
T62383	Anti-MRSA agent 2
	Anti-MRSA agent 2 (compound 14) 能够较好的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC: 0.098 μg/ml)，对正常细胞的毒性相对较低。Anti-MRSA agent 2 能够较强的破坏细菌膜，并具有较好的与细菌基因组DNA 结合的能力。
T36703	CAY10760
	CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib . 1.Bag...

化合物

Butylhydroxyanisole

Cat.No: T0787

Synonym: BHA,丁基羟基茴香醚,丁基大茴香醚,E320,Butylated hydroxyanisole

Target: Antioxidant, Ferroptosis, Reactive Oxygen Species

Cat.No: T13807

Synonym: CP248

Target: Microtubule Associated, PKA

Cat.No: TQ0055

Target: Glucokinase

Cat.No: T5626

Synonym: Aktikon,Chromozin,Gesaprim,莠去津,Oleogesaprim,阿特拉津

Target: Others

4-N-Nonyloxyphenol

Cat.No: T72049

Synonym: 4-nonoxyphenol,p-Nonyloxyphenol

Cat.No: T9093

Synonym: Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester

Target: c-Myc

Cat.No: T2060

Synonym: LR-510444,LR510444,LR 510444

Target: Apoptosis, Microtubule Associated

Cat.No: T9118

Target: Apoptosis, Others, Caspase

Cat.No: T14212

Target: Glucokinase

Cat.No: T34858

Synonym: THIQ 20c

Cat.No: T34711

Synonym: STAD-2,STAD2

Hsp90-Cdc37-IN-1

Cat.No: T13725

Target: Others

Cat.No: T68528

4-tert-Octylphenol diethoxylate

Cat.No: T38379

Cat.No: TP2129

Cat.No: T60539

Anti-MRSA agent 2

Cat.No: T62383

Cat.No: T36703

Cat. No.	Product Name	Target	Signaling Pathways
T5623	Bisphenol A	Others; Endogenous Metabolite	Metabolism; Others
	Bisphenol A 是酚类内源性代谢合成物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
T20273	Diamyl phthalate NSC 4720,NSC-4720,NSC4720
	Diamyl phthalate is an agent of endocrine disruptor.

天然产物

Cat.No: T5623

Target: Others, Endogenous Metabolite

Diamyl phthalate

Cat.No: T20273

Synonym: NSC 4720,NSC-4720,NSC4720

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