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14

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19836	2-Aminopurine	DNA/RNA Synthesis; PKA	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	2-Aminopurine 是一种鸟苷和腺苷的荧光类似物，是基于荧光衰变的 DNA 结构探针。当它插入寡核苷酸后，其荧光会通过与天然碱基堆积而被高度淬灭。它可用于核酸的结构和动力学的探测。
T12235	NMDI14	Others	Others
	NMDI14 是无义介导的 RNA 衰变抑制剂。
T16348	NS5806 NS-5806	Potassium Channel	Membrane transporter/Ion channel
	NS5806 是钾电流的激活剂，可增加 KV4.3/KChIP2峰值电流幅度，EC50值为 5.3 μM。它会在包含 KChIP2 的通道复合体中降低 KV4.2 和 KV4.3 电流衰减。
T30549	BMY-21502 Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168	Antioxidant	oxidation-reduction
	BMY-21502 是一种潜在认知增强剂，在KCN-缺氧模型中显示出抗缺氧作用，可在体外延缓海马突触增强的衰变，可用于研究阿尔茨海默症。
T0109	Molsidomine Morsydomine,SIN-10,吗多明,Corvaton	NOD	Immunology/Inflammation; NF-κB
	Molsidomine (Corvaton) 是一种长效的、口服活性的血管扩张药，在肝脏中代谢可被为活性代谢物Linsidomine。其中Linsidomine 是一种不稳定的化合物，能够产生NO，可用作血管舒张剂。
T77678	TZ3O	AChR	Neuroscience
	TZ3O是一种具有神经保护活性的抗胆碱能化合物。TZ3O 在Scopolamine诱导的阿尔茨海默型模型中改善大鼠记忆障碍与认知衰减，可用于研究阿兹海默症。
T3644	U93631	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	U93631 是一种具有新型化学结构的 GABAA 受体配体，IC50 为 100 nM，它在重组 GABAA 受体中诱导 GABA 诱导的全细胞 Cl 电流快速，这种效果随时间依赖性衰减。
T11170	eIF4A3-IN-1	Others	Others
	eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.
T71398	RO5126946
	RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.
T79062	IRE1α kinase-IN-8	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-8，作为苯并杂环甲醛衍生物，是一种高效的IRE-1α抑制剂，主要用于研究未折叠蛋白反应或受调节的IRE1依赖性衰减(RIDD)相关疾病。
T79063	IRE1α kinase-IN-9	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-9（compound 2）为一种有效IRE-1α抑制剂，其平均IC50值小于0.1 μM。该化合物适用于探究未折叠蛋白反应（UPR）及调控IRE1依赖性衰减（RIDD）相关疾病的研究。
T64049	KIRA9
	KIRA9 是 IRE1 的有效抑制剂，对 INS-1 细胞的 IC50 值为 4.8 μM。KIRA9 可以完全结合 IRE1 的 ATP 结合位点，并阻断内质网 (ER) 定位的 mRNA 衰减和细胞凋亡 (apoptosis)。
T36501	CYPMPO RR 071
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),...
T35419	τ-Fluvalinate
	τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ...

化合物

Cat.No: T19836

Target: DNA/RNA Synthesis, PKA

Cat.No: T12235

Target: Others

Cat.No: T16348

Synonym: NS-5806

Target: Potassium Channel

Cat.No: T30549

Synonym: Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168

Target: Antioxidant

Cat.No: T0109

Synonym: Morsydomine,SIN-10,吗多明,Corvaton

Target: NOD

Cat.No: T77678

Target: AChR

Cat.No: T3644

Target: GABA Receptor

Cat.No: T11170

Target: Others

Cat.No: T71398

IRE1α kinase-IN-8

Cat.No: T79062

Target: IRE1

IRE1α kinase-IN-9

Cat.No: T79063

Target: IRE1

Cat.No: T64049

Cat.No: T36501

Synonym: RR 071

Cat.No: T35419

Cat. No.	Product Name	Target	Signaling Pathways
TN7087	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone	Others	Others
	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio (Thermophillin) 是一种天然产物。它的氧化还原循环是木材褐腐真菌腐烂中Fe2+和H2O2再生的还原当量来源。
TN2798	20-Deoxocarnosol	ROS; Antifection	Immunology/Inflammation; Microbiology/Virology
	20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.
TN2625	14-Deoxycoleon U	Antifection	Microbiology/Virology
	14-Deoxycoleon U has anti-termitic activity, it is highly active against both wood-decay fungi. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and

天然产物

2,5-dimethoxycyclohexa-2,5-diene-1,4-dio

Cat.No: TN7087

Synonym: 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone

Target: Others

20-Deoxocarnosol

Cat.No: TN2798

Target: ROS, Antifection

14-Deoxycoleon U

Cat.No: TN2625

Target: Antifection

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