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Search Results for " deaminase "

27

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19179	Adenosine deaminase	Others	Others
	Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.
T60800	Deaminase inhibitor-1
	Deaminase inhibitor-1 是一种 APOBEC3G DNA 脱氨酶的抑制剂，IC50值为 18.9 μM。
T9111	8-Azaadenosine	Adenosine deaminase	Metabolism
	8-Azaadenosine 是 ADAR1抑制剂和是 A-to-I 编辑抑制剂。它可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。
T4006	Pentostatin Nipent,CI-825,Covidarabine,喷司他丁,Deoxycoformycin	Adenosine deaminase; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Pentostatin (CI-825) 是一种高亲和力的，不可逆的腺苷脱氨酶抑制剂，Ki 为 2.5 pM。
T2558	Cladribine 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis; Adenosine deaminase	Apoptosis; Metabolism
	Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。
T2169	Zebularine NSC309132,4-Deoxyuridine	DNA Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	Zebularine (4-Deoxyuridine) 是一种 DNA 甲基化抑制剂，还抑制胞苷脱氨酶。它通过以共价水合物的形式与活性大小结合，充当胞苷脱氨酶的过渡态类似物抑制剂。
T26972	Cedazuridine 西达尿苷,(4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine	DNA Methyltransferase	Chromatin/Epigenetic
	Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) 是一种口服的胞苷脱氨酶抑制剂，具有抗肿瘤特性。
T6987	β-Chloro-L-alanine 3-Chloro-L-alanine,3-氯-L-丙氨酸,L-β-Chloroalanine	Antibacterial	Microbiology/Virology
	β-Chloro-L-alanine (L-β-Chloroalanine) 是一种抑菌氨基酸类似物，可抑制多种酶，包括苏氨酸脱氨酶和丙氨酸消旋酶。
TNU0060	3’-O-Methyladenosine	Antiviral; Adenosine deaminase	Immunology/Inflammation; Metabolism
	3’-O-Methyladenosine 是一种抗病毒化合物，对西尼罗河病毒具有抑制作用，可用于治疗病毒感染。3’-O-Methyladenosine 对腺苷脱氨酶VII型具有抑制作用，Ki 值为 493 µM。
T50029	2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine 2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine	Others	Others
	2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine (2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine) 是一种杂环化合物。它可以抑制单胺氧化酶，导致体内单胺水平升高；也可以抑制腺苷脱氨酶，导致体内腺苷水平升高；还可以可以增加某些神经递质的活性，包括血清素和多巴胺。
T23634	Adecypenol OM-3223,OM3223,OM 3223,Antibiotic OM 3223
	Adecypenol is a unique adenosine deaminase inhibitor. It shows effective inhibitory activity against calf intestinal adenosine deaminase.
T70255	Elapegademase
	Elapegademase is an Adenosine Deaminase Inhibitor
T27383	FR-221647
	FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.
T27384	FR-234938 FR 234938
	FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.
T10015	1-Deazaadenosine	Others	Others
	1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders.
T10308	AMPD2 inhibitor 1	Others	Others
	AMPD2 inhibitor 1 is an inhibitor of adenosine monophosphate deaminase 2 (AMPD2), used in the research of salt craving, sugar craving, umami craving, and addictions including tobacco, drug, nicotine and alcohol addictions.
T15343	Fosteabine YNK 01,Cytarabine ocfosfate,阿糖胞苷烷磷酯	Others	Others
	Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.
T37106	2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)
	2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations ...
T60701	Fludarabine-Cl
	Fludarabine-Cl 抑制 RNA 腺苷脱氨酶1 (ADAR1) ，它可用于预防和/或治疗与肿瘤或癌症相关的疾病。
T38346	ABT 702 hydrochloride
	Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.
T77703	2,4-Dimethylpyrrole	Others	Others
	2,4-Dimethylpyrrole 是一种有效的卟啉原脱氨酶抑制剂，用于治疗和/或预防先天性红细胞生成性卟啉症（CEP）。
T60553	Tetrahydrouridine dihydrate
	Tetrahydrouridine dihydrate (THU dihydrate) 是有效的胞苷脱氨酶抑制剂。Tetrahydrouridine dihydrate 比内在胞苷更有效地竞争性阻断酶的活性位点。
T40566	2′-O-(2-Methoxyethyl)guanosine 2′-O-(2-Methoxyethyl)guanosine,2'-O-MOE-rG
	2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a modified nucleoside, can be enzymatically converted from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside by adenosine deaminase. However, this compound is not readily phosphorylated by cytosolic nucleoside kinases, and it cannot be incorporated into cellular DNA or RNA.
T60708	Cedazuridine hydrochloride
	Cedazuridine (E7727) (Compound 7a) hydrochloride 是一种可用于研究癌症的，口服有效的胞苷脱氨酶 (CDA) 抑制剂 (IC 50 = 0.4 μM)。
T72635	AMPD2 inhibitor 2
	AMPD2 inhibitor 2是一种针对AMP脱氨酶2 (AMPD2) 的高效抑制剂，具有针对hAMPD2和mAMPD2较低的IC50值，分别为0.1 μM 和 0.28 μM。该化合物可能对于探究AMPD2在高脂肪饮食小鼠模型中的生理功能具有重要意义。
T11168	EHNA hydrochloride	Others	Others
	EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity.
T17059	Tetrahydrouridine NSC 112907,NSC112907,四氢尿苷,NSC-112907	DNA Methyltransferase	Chromatin/Epigenetic
	Tetrahydrouridine (NSC-112907; THU) 是一种多药耐药调节剂。它可用于癌症治疗，使肿瘤细胞对放射治疗更加敏感。它是一种竞争性胞苷脱氨酶 (CDA) 抑制剂，可抑制 ara-C 和吉西他滨等细胞毒性脱氧胞苷类似物分解代谢中的脱氨作用。

化合物

Adenosine deaminase

Cat.No: T19179

Target: Others

Deaminase inhibitor-1

Cat.No: T60800

Cat.No: T9111

Target: Adenosine deaminase

Cat.No: T4006

Synonym: Nipent,CI-825,Covidarabine,喷司他丁,Deoxycoformycin

Target: Adenosine deaminase, Adenosine Receptor

Cat.No: T2558

Synonym: 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

Cat.No: T2169

Synonym: NSC309132,4-Deoxyuridine

Target: DNA Methyltransferase, Autophagy

Cat.No: T26972

Synonym: 西达尿苷,(4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine

Target: DNA Methyltransferase

β-Chloro-L-alanine

Cat.No: T6987

Synonym: 3-Chloro-L-alanine,3-氯-L-丙氨酸,L-β-Chloroalanine

Target: Antibacterial

3’-O-Methyladenosine

Cat.No: TNU0060

Target: Antiviral, Adenosine deaminase

2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine

Cat.No: T50029

Synonym: 2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine

Target: Others

Cat.No: T23634

Synonym: OM-3223,OM3223,OM 3223,Antibiotic OM 3223

Cat.No: T70255

Cat.No: T27383

Cat.No: T27384

Synonym: FR 234938

1-Deazaadenosine

Cat.No: T10015

Target: Others

AMPD2 inhibitor 1

Cat.No: T10308

Target: Others

Cat.No: T15343

Synonym: YNK 01,Cytarabine ocfosfate,阿糖胞苷烷磷酯

Target: Others

2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Cat.No: T37106

Cat.No: T60701

ABT 702 hydrochloride

Cat.No: T38346

2,4-Dimethylpyrrole

Cat.No: T77703

Target: Others

Tetrahydrouridine dihydrate

Cat.No: T60553

2′-O-(2-Methoxyethyl)guanosine

Cat.No: T40566

Synonym: 2′-O-(2-Methoxyethyl)guanosine,2'-O-MOE-rG

Cedazuridine hydrochloride

Cat.No: T60708

AMPD2 inhibitor 2

Cat.No: T72635

EHNA hydrochloride

Cat.No: T11168

Target: Others

Tetrahydrouridine

Cat.No: T17059

Synonym: NSC 112907,NSC112907,四氢尿苷,NSC-112907

Target: DNA Methyltransferase

Cat. No.	Product Name	Target	Signaling Pathways
TN1736	Hibifolin 棉皮素-8-O-Β-D-葡萄糖醛酸苷,棉花皮素-8-O-葡萄糖醛酸苷	Adenosine deaminase	Metabolism
	Hibifolin 是一种黄酮醇糖苷，是潜在的腺苷脱氨酶抑制剂。它可以保护神经元免受 beta-淀粉样蛋白诱导的毒性。
T13482	2'-O-Methyladenosine	Endogenous Metabolite	Metabolism
	2'-O-Methyladenosine 是甲基化腺嘌呤的残基，在正常人群和腺苷脱氨基酶缺乏病人的尿液中均可被检测到。它显示出独特的降血压活性。
T4901	5'-Guanylic acid disodium salt Guanosine 5'-monophosphate disodium salt,5'-鸟苷酸二钠,鸟苷钠5'-单磷酸,GMP-5	Others; Endogenous Metabolite	Metabolism; Others
	5'-Guanylic acid disodium salt (GMP-5) 由鸟嘌呤，核糖和磷酸组成，是信使 RNA 中的一种核苷酸单体。鸟苷衍生物参与细胞内信号转导，并已鉴定存在于端粒，核糖体 DNA，免疫球蛋白重链转换区和原癌基因的控制区中的重复基因组序列中。
T19146	5,6-Dihydrouridine	Endogenous Metabolite	Metabolism
	5,6-Dihydrouridine 是一种修饰碱基，存在于真核生物、细菌和某些古细菌tRNA D 环的保守位置。
T23905	Coformycin NSC 277817
	Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.
T19346	5'-Guanylic acid 鸟苷酸,5'-guanosine monophosphate,5'-GMP	Endogenous Metabolite	Metabolism
	5'-Guanylic acid (5'-guanosine monophosphate) 与几种代谢紊乱有关，包括腺苷脱氨酶缺乏症、 aica-核糖体途径、腺嘌呤磷酸转移酶缺乏症 (aprt) 以及 2-羟基葡糖酸盐途径。
T0665	Xanthine 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine	Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Xanthine (Isoxanthine) 是一种植物生物碱，存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂，也是嘌呤降解途径的中间产物。

天然产物

Cat.No: TN1736

Synonym: 棉皮素-8-O-Β-D-葡萄糖醛酸苷,棉花皮素-8-O-葡萄糖醛酸苷

Target: Adenosine deaminase

2'-O-Methyladenosine

Cat.No: T13482

Target: Endogenous Metabolite

5'-Guanylic acid disodium salt

Cat.No: T4901

Synonym: Guanosine 5'-monophosphate disodium salt,5'-鸟苷酸二钠,鸟苷钠5'-单磷酸,GMP-5

Target: Others, Endogenous Metabolite

5,6-Dihydrouridine

Cat.No: T19146

Target: Endogenous Metabolite

Cat.No: T23905

Synonym: NSC 277817

5'-Guanylic acid

Cat.No: T19346

Synonym: 鸟苷酸,5'-guanosine monophosphate,5'-GMP

Target: Endogenous Metabolite

Cat.No: T0665

Synonym: 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

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