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Search Results for " channel block "

13

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6134	IEM 1754 2HBr IEM 1754 dihydrobromide	GluR	Neuroscience
	IEM 1754 2HBr (IEM 1754 dihydrobromide) 是一种选择性 AMPA/红藻氨酸受体阻滞剂，作用于 GluR1 和 GluR3，IC50 为 6 μM。
T10101	Calcium channel-modulator-1	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM)，具有阻塞主动脉收缩的专业化。
T3543	NS-638 NS 638	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	NS-638 是一种 Ca2+ 通道阻滞剂，可阻断 K+ 刺激的细胞内 Ca2+ 升高，IC50值为3.4 μM。
T13320	VU591 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。
T6186	TRAM-34 Triarylmethane-34,TRAM 34	Potassium Channel; IκB/IKK	Membrane transporter/Ion channel; NF-κB
	TRAM-34 (Triarylmethane-34) 是一种高选择性的钙激活 K+通道 (IKCa1)阻断剂，Kd 值为 20 nM。
T22178L	Spadin Acetate Spadin Acetate(1270083-24-3 Free base)	Others	Others
	Spadin Acetate 是一种天然肽，来源于血液中释放的前肽。 Spadin Acetate 能够阻断 TREK-1 通道活动。 Spadin Acetate 与 TREK-1 特异性结合，亲和力为 10 nM。
T12153	N-type calcium channel blocker-1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
T25312	Detajmium Tachmalcor
	Detajmium 是一种抗心律失常的化合物。它是一种钠（+）通道阻断药物，从使用依赖性钠通道阻断中恢复时间极长。
T19591	Triamterene D5 氨苯蝶啶 D5	Others	Others
	Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.
T16135	MRS 1523	Others	Others
	MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 receptor antagonist Ki: 18.9 nM and 113 n
T61475	Ropivacaine mesylate
	Ropivacaine mesylate 是一种高效的钠通道 (sodium channel) 阻断剂，通过可逆性抑制钠离子内流 (sodium ion influx)，引致神经纤维脉冲传导阻滞。此外，Ropivacaine 还能抑制 K2P(双孔钾通道)TREK-1，其在 COS-7 细胞膜上的 IC50 值为 402.7 μM。
T69652	Relutrigine PRAX-562
	Relutrigine (PRAX-562) 是一种口服活性的持久性钠通道 (sodium channel) 抑制剂，能够有效优先抑制由 ATX-II (Nav 1.5 激活剂) 或 SCN8A 突变 N1768D 引起的持续性 INa，其 IC50 值分别为 141 nM 和 75 nM。该化合物通过使用依赖性阻断方式，降低神经元的内在兴奋性，显示出明显的抗惊厥活性。
T35922	NAADP (sodium salt)
	Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to...

化合物

Cat.No: T6134

Synonym: IEM 1754 dihydrobromide

Target: GluR

Calcium channel-modulator-1

Cat.No: T10101

Target: Others, Calcium Channel

Cat.No: T3543

Synonym: NS 638

Target: Calcium Channel

VU591 hydrochloride

Cat.No: T13320

Target: Potassium Channel

Cat.No: T6186

Synonym: Triarylmethane-34,TRAM 34

Target: Potassium Channel, IκB/IKK

Cat.No: T22178L

Synonym: Spadin Acetate(1270083-24-3 Free base)

Target: Others

N-type calcium channel blocker-1

Cat.No: T12153

Target: Calcium Channel

Cat.No: T25312

Synonym: Tachmalcor

Cat.No: T19591

Synonym: 氨苯蝶啶 D5

Target: Others

Cat.No: T16135

Target: Others

Ropivacaine mesylate

Cat.No: T61475

Cat.No: T69652

Synonym: PRAX-562

NAADP (sodium salt)

Cat.No: T35922

Cat. No.	Product Name	Target	Signaling Pathways
T2732	(-)-Epicatechin gallate 表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG	Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) 抑制环加氧酶-1 的IC50值为 7.5 μM。
T12373	Paxilline	Others	Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.

天然产物

(-)-Epicatechin gallate

Cat.No: T2732

Synonym: 表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG

Target: Virus Protease, COX, Autophagy

Cat.No: T12373

Target: Others

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