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Search Results for " cardioprotection "

11

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12870	SCH79797 dihydrochloride	Apoptosis; Others; Protease-activated Receptor	Apoptosis; GPCR/G Protein; Others
	SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂，IC50 为 70 nM，Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。
T37890L	GLP-1(28-36)amide acetate GLP-1(28-36)amide acetate(1225021-13-5 Free base)	Antioxidant; Glucagon Receptor	GPCR/G Protein; oxidation-reduction
	GLP-1(28-36)amide acetate 抑制线粒体通透性转变，具有抗氧化、抗糖尿病和心脏保护活性。
T22305	Dexrazoxane 右雷佐生,ICRF-187	Others	Others
	Dexrazoxane (ICRF-187) 是一种心脏保护剂。
T21871	MMPSI Caspase-3/7 Inhibitor I	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂，可减少离体兔心脏或心肌细胞缺血性损伤的作用，以浓度依赖性方式抑制 H16c2 细胞凋亡。MMPSI 可用于研究心脏保护和心肌损伤。
T16420	P-1075	Potassium Channel	Membrane transporter/Ion channel
	P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂，EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧，产生保护心脏的功效。
T25102	Aprikalim RP52891,RP-52891,RP 52891
	Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.
T61540	F15845
	F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1].
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T37890	GLP-1(28-36)amide
	GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1].
T78007	Vasonatrin Peptide (VNP) TFA
	Vasonatrin Peptide (VNP) TFA 是一种由心钠素 (ANP) 和C型利钠肽 (CNP) 嵌合而成的肽类化合物。它整合了CNP的静脉扩张功能、ANP的利尿效果，并展现出与ANP或CNP无关的特有动脉扩张特性。Vasonatrin Peptide TFA 透过cGMP-PKG信号途径发挥其对内质网应激介导的糖尿病心脏缺血再灌注损害的保护作用。
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...

化合物

SCH79797 dihydrochloride

Cat.No: T12870

Target: Apoptosis, Others, Protease-activated Receptor

GLP-1(28-36)amide acetate

Cat.No: T37890L

Synonym: GLP-1(28-36)amide acetate(1225021-13-5 Free base)

Target: Antioxidant, Glucagon Receptor

Cat.No: T22305

Synonym: 右雷佐生,ICRF-187

Target: Others

Cat.No: T21871

Synonym: Caspase-3/7 Inhibitor I

Target: Apoptosis, Caspase

Cat.No: T16420

Target: Potassium Channel

Cat.No: T25102

Synonym: RP52891,RP-52891,RP 52891

Cat.No: T61540

Cat.No: T70421

GLP-1(28-36)amide

Cat.No: T37890

Vasonatrin Peptide (VNP) TFA

Cat.No: T78007

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Cat. No.	Product Name	Target	Signaling Pathways
T4721	β-Nicotinamide mononucleotide β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-Nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
T2961	Notoginsenoside R1 Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1	Apoptosis; ERK; Beta Amyloid	Apoptosis; MAPK; Neuroscience
	Notoginsenoside R1 (Sanchinoside R1) 是一种从三七中分离出来的皂苷，具有抗氧化、抗炎、抗血管生成和抗凋亡的活性。它有神经保护和抗缺血/再灌注损伤的心脏保护作用。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T2S1008	Oxysophoridine Sophoridine N-oxide,氧化槐定碱	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱，具有抗发炎，抗氧化应激和抗凋亡的作用。
T7028	Licochalcone C LICOCHALCONEC,甘草查尔酮C	Phosphatase; Antioxidant; Glucosidase	Metabolism; oxidation-reduction
	Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶，其对 α-葡萄糖苷酶的 IC50 <100 nM，对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。

天然产物

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

Notoginsenoside R1

Cat.No: T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1

Target: Apoptosis, ERK, Beta Amyloid

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T2S1008

Synonym: Sophoridine N-oxide,氧化槐定碱

Target: Apoptosis, Antioxidant

Cat.No: T7028

Synonym: LICOCHALCONEC,甘草查尔酮C

Target: Phosphatase, Antioxidant, Glucosidase

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