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Search Results for " anxiolytic effect "

11

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4508	Glycyl-L-Histidyl-L-Lysine	Others	Others
	Glycyl-L-Histidyl-L-Lysine 是一种肝细胞生长因子和一种合成的肝营养剂，可刺激肝红细胞生成因子的产生。
T12841	SB-224289 hydrochloride SB-224289A	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB-224289 hydrochloride (SB-224289A) 是一种选择性的 5-HT1B receptor 拮抗剂，具有抗焦虑作用。
T13690	Etifoxine hydrochloride 盐酸艾替伏辛,HOE 36-801 hydrochloride	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Etifoxine hydrochloride (HOE 36-801 hydrochloride) 是GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂，是具有 GABA 能的非苯二氮卓类抗焦虑和抗惊厥药物。
T15022	CVT-10216 3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸	Dehydrogenase	Metabolism
	CVT-10216 是可逆的、选择性的醛脱氢酶 2（ALDH-2）抑制剂，IC50为 29 nM。对 ALDH-1的抑制作用较弱，IC50为 1.3 μM。它可以减少偏爱酒精的大鼠过量饮酒，并表现出抗焦虑作用。
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
T80422	Phoenixin-14 PNX-14	GNRH Receptor	GPCR/G Protein
	Phoenixin-14 (PNX-14) 是一种具有内源性活性的异构体，能通过激活AHA GnRH系统发挥抗焦虑效果，并抑制缺血/再灌注所诱导的小胶质细胞毒性。
T80423	Phoenixin-20 PNX-20	Epigenetic Reader Domain	Chromatin/Epigenetic
	Phoenixin-20（PNX-20）为脊椎动物内具激素样生物活性肽，能激活下丘脑-垂体-性腺轴，调控哺乳类生殖过程。该肽通过CREB-PGC-1α途径增进神经元线粒体生物发生。
T37114	SB 242084 dihydrochloride
	SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9....
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...
T37094	(S)-UFR2709 hydrochloride (S)-UFR2709 hydrochloride
	(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2]. Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, whi...
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Glycyl-L-Histidyl-L-Lysine

Cat.No: T4508

Target: Others

SB-224289 hydrochloride

Cat.No: T12841

Synonym: SB-224289A

Target: 5-HT Receptor

Etifoxine hydrochloride

Cat.No: T13690

Synonym: 盐酸艾替伏辛,HOE 36-801 hydrochloride

Target: GABA Receptor

Cat.No: T15022

Synonym: 3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸

Target: Dehydrogenase

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: T80422

Synonym: PNX-14

Target: GNRH Receptor

Cat.No: T80423

Synonym: PNX-20

Target: Epigenetic Reader Domain

SB 242084 dihydrochloride

Cat.No: T37114

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

(S)-UFR2709 hydrochloride

Cat.No: T37094

Synonym: (S)-UFR2709 hydrochloride

Cat.No: T38145

Cat. No.	Product Name	Target	Signaling Pathways
T3748	orcinol 5-Methylresorcinol,苔黑素、苔黑酚、地衣酚,3,5-Dihydroxytoluene,3,5-二羟基甲苯,地衣酚,5-Methylresorcin,3,5-ToluenediolOrcin,5-Methyl-1,3-benzenediol,Orcin	Others	Others
	orcinol (5-Methylresorcin) 可用于生物染料和蛋白质组学研究。
T4S1999	Valepotriate 戊曲酯/缬草素,Valtrate	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物，是一类新的细胞毒剂和抗肿瘤剂，对 HTC 肝癌细胞是非常有效的细胞毒剂。它可能对焦虑的精神症状具有潜在的抗焦虑作用。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。

天然产物

Cat.No: T3748

Synonym: 5-Methylresorcinol,苔黑素、苔黑酚、地衣酚,3,5-Dihydroxytoluene,3,5-二羟基甲苯,地衣酚,5-Methylresorcin,3,5-ToluenediolOrcin,5-Methyl-1,3-benzenediol,Orcin

Target: Others

Cat.No: T4S1999

Synonym: 戊曲酯/缬草素,Valtrate

Target: Apoptosis, HIV Protease

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

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