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Search Results for " antithrombotic activity "

21

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T67991	Iliparcil	Others	Others
	Iliparcil 是一种具有口服活性的抗血栓化合物。
T4076	Fondaparinux sodium Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra	Factor Xa	Metabolism
	Fondaparinux sodium (SR-90107A) 是抗凝血酶依赖性的 factor Xa 抑制剂。
T13210	Trombodipine PCA-4230	Antibiotic	Microbiology/Virology
	Trombodipine (PCA-4230) 是一种血小板聚集抑制剂，具有抗血栓活性，对单核细胞增生李斯特菌具有保护作用。
T80792	WAY-639228	Others	Others
	WAY-639228-A 具有潜在的抗血栓和抗凝活性，可用于研究脑血栓。
T25741	Linotroban HN 11500,CL-871502	PPAR	DNA Damage/DNA Repair; Metabolism
	Linotroban（CL-871502）是一种有效的选择性血栓素（TXA2）受体拮抗剂，具有抗血栓活性。
T27318	Fidexaban CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834	Factor Xa	Metabolism
	Fidexaban (CI1031) 是一种新型、强效、选择性和口服活性 Xa 因子抑制剂，在多种测定中均显示出抗血栓活性。
T27920	LY 517717 LY-517717,LY517717	Factor Xa	Metabolism
	LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。
T17025	Tecarfarin ATI-5000,ATI-5923	Others	Others
	Tecarfarin (ATI-5923) 是一种具有口服活性和有效性的维生素 K 环氧化物还原酶 (VKOR) 拮抗剂和大麻素-1受体反向激动剂，具有抗血栓形成活性，可减轻小鼠的腹痛并增加肠道转运。
T63966	BMS-986141 UDM-003183	Protease-activated Receptor	GPCR/G Protein
	BMS-986141(UDM-003183) 是一种具有口服活性的选择性和高效性的凝血酶受体蛋白酶激活受体-4 (protease-activated receptor-4 (PAR-4)) 拮抗剂，其 IC50 值为 0.4 nM。BMS-98614 表现出显著的抗血栓作用。
T17024	Tecarfarin sodium ATI-5923 sodium	Others	Others
	Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity.
T17091	Thrombin Inhibitor 2	Others	Others
	Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity.
T70458	FXIa-6f
	FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
T70909	AY 31390
	AY 31390 is a phosphodiesterase (PDE) inhibitor with antithrombotic activity.
T12694	Razaxaban hydrochloride BMS 561389 hydrochloride,DPC 906 hydrochloride	Others	Others
	Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.
T12782	RWJ-445167 3DP-10017	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T16377	Odiparcil SB-424323	Thrombin	Proteases/Proteasome
	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.
T33579	Nafazatrom Nafazatromum
	Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacyclin levels and reduces the inciden
T36759	SAR 216471 hydrochloride
	Potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available. Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID:25075638
T81791	MIPS-21335	PI4K	PI3K/Akt/mTOR signaling
	MIPS-21335为PI3KC2α抑制剂（IC50：0.007 μM），亦能抑制PI3KC2β、p110α、p110β及p110δ（IC50分别为0.043、0.140、0.386、0.742 μM）。本化合物展现出抗血栓作用。
T79847	Frunexian EP-7041	Factor Xa	Metabolism
	Frunexian (EP-7041) 为针对 Factor XIa 的选择性有效凝血因子 XI/活化因子 XI 抑制剂，展现抗血栓活性，且在大鼠肠系膜动脉穿刺模型中显示出无出血倾向。此化合物亦可应用于体外膜氧合(ECMO)的研究领域。
T61811	GPVI antagonist 3
	GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antago...

化合物

Cat.No: T67991

Target: Others

Fondaparinux sodium

Cat.No: T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra

Target: Factor Xa

Cat.No: T13210

Synonym: PCA-4230

Target: Antibiotic

Cat.No: T80792

Target: Others

Cat.No: T25741

Synonym: HN 11500,CL-871502

Target: PPAR

Cat.No: T27318

Synonym: CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834

Target: Factor Xa

Cat.No: T27920

Synonym: LY-517717,LY517717

Target: Factor Xa

Cat.No: T17025

Synonym: ATI-5000,ATI-5923

Target: Others

Cat.No: T63966

Synonym: UDM-003183

Target: Protease-activated Receptor

Tecarfarin sodium

Cat.No: T17024

Synonym: ATI-5923 sodium

Target: Others

Thrombin Inhibitor 2

Cat.No: T17091

Target: Others

Cat.No: T70458

Cat.No: T70909

Razaxaban hydrochloride

Cat.No: T12694

Synonym: BMS 561389 hydrochloride,DPC 906 hydrochloride

Target: Others

Cat.No: T12782

Synonym: 3DP-10017

Target: Factor Xa, Thrombin

Cat.No: T16377

Synonym: SB-424323

Target: Thrombin

Cat.No: T33579

Synonym: Nafazatromum

SAR 216471 hydrochloride

Cat.No: T36759

Cat.No: T81791

Target: PI4K

Cat.No: T79847

Synonym: EP-7041

Target: Factor Xa

GPVI antagonist 3

Cat.No: T61811

Cat. No.	Product Name	Target	Signaling Pathways
T4853	TRIA-662 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate	Others; Endogenous Metabolite	Metabolism; Others
	TRIA-662 (Nicotinamide Chloromethylate) 是内源性代谢产物的一种。
T2S0504	Ilexoside D	Others	Others
	Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity.
T13302	Viquidil hydrochloride Quinotoxine hydrochloride	Others	Others
	Viquidil hydrochloride (Quinotoxine hydrochloride) 是奎尼丁的同分异构体，是一种脑血管扩张剂，具有抗血栓作用。
TN1996	Nothofagin	ERK; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; MAPK
	Nothofagin 具有抗氧化和抗血栓活性，它通过抑制高渗透性、CAMs 的表达以及白细胞的粘附和迁移具有抗炎活性，从而支持其作为血管炎症性疾病的治疗作用。

天然产物

Cat.No: T4853

Synonym: 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate

Target: Others, Endogenous Metabolite

Cat.No: T2S0504

Target: Others

Viquidil hydrochloride

Cat.No: T13302

Synonym: Quinotoxine hydrochloride

Target: Others

Cat.No: TN1996

Target: ERK, IL Receptor, TNF

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