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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8383	Cyclopentolate Hydrochloride	AChR	Neuroscience
	Cyclopentolate Hydrochloride 是一种阿托品样毒蕈碱受体拮抗剂，是眼科常用的抗毒蕈碱剂，对睫状肌毒蕈碱受体的 pKB 值为 7.8。
T9353	OXOMEMAZINE	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂，具有明显的抗毒蕈碱活性。它是基于吩噻嗪的组胺 H1 受体阻滞剂，是抗组胺和抗胆碱能试剂，可用于咳嗽相关研究。
T5023	Propiverine hydrochloride	Others; Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Propiverine hydrochloride 是一种痉挛剂，具有钙拮抗和抗胆碱能特性，用于研究膀胱过度活动和尿失禁。
T9419	Fesoterodine (R) Fesoterodine,弗斯特罗定	AChR	Neuroscience
	Fesoterodine ((R) Fesoterodine) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T0786	Clidinium bromide 克利溴铵,Ro 2-3773	AChR	Neuroscience
	Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂，可通过减少胃酸和减慢肠道速度，缓解痉挛和腹部疼痛的症状。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T0862	Diphenidol hydrochloride Diphenidol HCl,盐酸地芬尼多,Difenidol hydrochloride	Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Diphenidol hydrochloride (Difenidol hydrochloride) 是一种非选择性的毒蕈碱 M1-M4 受体拮抗剂，具有抗心律失常活性，用作抗眩晕药和止吐药。它也是神经细胞电压门控离子通道的有效非特异性阻滞剂。
T0427	Homatropine Methylbromide Homatropine methobromide,溴甲基后马托品	AChR	Neuroscience
	Homatropine Methylbromide 是一种毒蕈碱受体 AChR 拮抗剂，抑制 WKY-E 和 SHR-E ，IC50分别为 162.5 和 170.3 nM。
T9877	Tiquizium	AChR	Neuroscience
	Tiquizium 具有有效的抗毒蕈碱作用，并在慢性阻塞性肺病患者中引起显着的支气管扩张。
T1474	Otilonium bromide Octylonium bromide,奥替溴铵,SP63	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Otilonium bromide (SP63) 是一种抗毒蕈碱药，用作解痉剂。
T7002	Trihexyphenidyl hydrochloride Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride,盐酸苯海索	AChR	Neuroscience
	Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物，结合至M1毒蕈碱受体。
T2138	Oxyphencyclimine Hydrochloride 盐酸奥克西利平,Spazamin,Daricon,Ulcociclinina	AChR	Neuroscience
	Oxyphencyclimine Hydrochloride (Ulcociclinina) 是一种合成的叔胺和抗毒蕈碱剂，具有抗痉挛和抗分泌活性。
T9420	prifinium bromide	Others	Others
	Prifinium bromide 是抗胆碱能试剂，能够改善痉挛，具有止吐效果。
T2222	Carbinoxamine Maleate Salt Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Carbinoxamine Maleate Salt (Lergefin) 是一种乙醇胺类 H1 抗组胺药，具有温和的抗毒蕈碱和镇静作用。
T7555	Piperidolate hydrochloride	AChR	Neuroscience
	Piperidolate hydrochloride 是一种抗毒蕈碱药，可抑制乙酰胆碱引起的异常活性，能抑制大鼠和狗的肠痉挛。
T1197	Trimebutine maleate Debridat,Polibutin,马来酸曲美布汀	Calcium Channel; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Trimebutine maleate (Polibutin) 是一种外周 μ、δ 和 kappa 阿片受体激动剂，用作治疗慢性和急性腹痛的解痉药物。
T67956L	Litoxetine HCl litoxetine HCL(86811-09-8 Free base)	5-HT Receptor	GPCR/G Protein; Neuroscience
	Litoxetine HCl 是一种选择性5-羟色胺（5-HT）再摄取抑制剂（SSRI）和混合5-羟色胺拮抗剂，可用于治疗尿失禁。Litoxetine HCl 在没有抗毒蕈碱特性的浓度下（10 nM-1 microM）引起大鼠离体食道肌肉粘膜的浓度依赖性松弛，使卡巴胆碱张力降低达37%,更高浓度的Litoxetine HCl（3微摩-300微摩）与明显的松弛有关，直至取消卡巴胆碱张力。以前在离体豚鼠肠道中证明的利托西汀的抗心律失常活性，在浓度大于1 microM 时在大鼠离体食道肌肉粘膜中发挥了作用。 Litoxetine HCl 的5-HT 释放作用可以解释利托西汀对未处理的大鼠组织中的5-HT 诱导的松弛的效力，这种效力被pCPA 处理所逆转。
T0918	Trimebutine 曲美布汀,Mebutin	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Trimebutine (Mebutin) 是阿片受体激动剂，有抗毒蕈碱活性。它是解痉剂，可调节肠道和结肠运动，并通过抗毒蕈碱和弱μ-阿片受体激动剂作用缓解腹痛。
T28941	Telenzepine
	Telenzepine is a potent and selective M1 antimuscarinic.
T23998	Dihexyverine HCl Olimplex,Neospasmina,Diverine,Dihexyverine hydrochloride,Seclin
	Dihexyverine HCl is an antimuscarinic with effects similar to those of atropine.
T28523	Revatropate UK-112 166,UK 112166,UK-112,166
	Revatropate, a selective muscarinic antagonist, is an antimuscarinic drug.
T31678	Espatropate UK-88060
	Espatropate is a bronchodilator with antimuscarinic activity.
T11275	Fesoterodine L-mandelate	Others	Others
	Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB).
T0703L	Flavoxate Uronid,Spasuret,Bladuril,Urispas
	Flavoxate is an anticholinergic with antimuscarinic effects.
T23852	Caramiphen
	Caramiphen is an antimuscarinic and anticholinergic agent that acts as an antagonist of the NMDA receptor.
T69234	Piperilate HCl
	Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist.
T0346	Camylofine Avacan,卡米罗芬,Acamylophenine,Camylofin,Adopon	Others; AChR	Neuroscience; Others
	Camylofine (Avacan) 是抗胆碱剂，也是一种平滑肌松弛剂。
T34936	Tridihexethyl chloride Propethonum,Pathilon,Tridihexethyl
	Tridihexethyl is an anticholinergic, antimuscarinic, and antispasmolytic drug, which can be used to treat acquired nystagmus or peptic ulcer disease.
T71107	Caramiphen hydrochloride
	Caramiphen hydrochloride is the salt form of Caramiphne (free base), which is an antimuscarinic and anticholinergic agent. It acts as an antagonist of NMDA receptor.
T61309	(R)-Oxybutynin
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T71268	Esoxybutynin Free Base
	Esoxybutynin Free Base is (S)-enantiomer of oxybutynin. Esoxybutynin Free Base exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T61438	Propiverine
	Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2].
T71889	Esoxybutynin Chloride
	Esoxybutynin Chloride is (S)-enantiomer of oxybutynin. Esoxybutynin Chloride exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.
T35616	Migrastatin
	Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mam...
T36204	Methylatropine (nitrate)
	Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotin...

化合物

Cyclopentolate Hydrochloride

Cat.No: T8383

Target: AChR

Cat.No: T9353

Target: AChR, Histamine Receptor

Propiverine hydrochloride

Cat.No: T5023

Target: Others, Calcium Channel, AChR

Cat.No: T9419

Synonym: (R) Fesoterodine,弗斯特罗定

Target: AChR

Clidinium bromide

Cat.No: T0786

Synonym: 克利溴铵,Ro 2-3773

Target: AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Diphenidol hydrochloride

Cat.No: T0862

Synonym: Diphenidol HCl,盐酸地芬尼多,Difenidol hydrochloride

Target: Sodium Channel, AChR

Homatropine Methylbromide

Cat.No: T0427

Synonym: Homatropine methobromide,溴甲基后马托品

Target: AChR

Cat.No: T9877

Target: AChR

Otilonium bromide

Cat.No: T1474

Synonym: Octylonium bromide,奥替溴铵,SP63

Target: Calcium Channel, AChR

Trihexyphenidyl hydrochloride

Cat.No: T7002

Synonym: Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride,盐酸苯海索

Target: AChR

Oxyphencyclimine Hydrochloride

Cat.No: T2138

Synonym: 盐酸奥克西利平,Spazamin,Daricon,Ulcociclinina

Target: AChR

prifinium bromide

Cat.No: T9420

Target: Others

Carbinoxamine Maleate Salt

Cat.No: T2222

Synonym: Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate

Target: Histamine Receptor

Piperidolate hydrochloride

Cat.No: T7555

Target: AChR

Trimebutine maleate

Cat.No: T1197

Synonym: Debridat,Polibutin,马来酸曲美布汀

Target: Calcium Channel, Opioid Receptor

Cat.No: T67956L

Synonym: litoxetine HCL(86811-09-8 Free base)

Target: 5-HT Receptor

Cat.No: T0918

Synonym: 曲美布汀,Mebutin

Target: Opioid Receptor

Cat.No: T28941

Dihexyverine HCl

Cat.No: T23998

Synonym: Olimplex,Neospasmina,Diverine,Dihexyverine hydrochloride,Seclin

Cat.No: T28523

Synonym: UK-112 166,UK 112166,UK-112,166

Cat.No: T31678

Synonym: UK-88060

Fesoterodine L-mandelate

Cat.No: T11275

Target: Others

Cat.No: T0703L

Synonym: Uronid,Spasuret,Bladuril,Urispas

Cat.No: T23852

Cat.No: T69234

Cat.No: T0346

Synonym: Avacan,卡米罗芬,Acamylophenine,Camylofin,Adopon

Target: Others, AChR

Tridihexethyl chloride

Cat.No: T34936

Synonym: Propethonum,Pathilon,Tridihexethyl

Caramiphen hydrochloride

Cat.No: T71107

Cat.No: T61309

Esoxybutynin Free Base

Cat.No: T71268

Cat.No: T61438

Esoxybutynin Chloride

Cat.No: T71889

Cat.No: T35616

Methylatropine (nitrate)

Cat.No: T36204

Cat. No.	Product Name	Target	Signaling Pathways
TN1875	Liriodenine 鹅掌揪碱	BCL; Caspase; p53	Apoptosis; Proteases/Proteasome
	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti

天然产物

Cat.No: TN1875

Synonym: 鹅掌揪碱

Target: BCL, Caspase, p53

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