Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1385 |
Amlodipine
氨氯地平,UK-48340 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Amlodipine (UK-48340) 是可口服的二氢吡啶钙通道阻滞剂,有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道,从而抑制钙离子内流,用于高血压和癌症的研究。 | |||
T0231 |
Amlodipine Besylate
Amlodipine benzenesulfonate,苯磺酸氨氯地平 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Amlodipine Besylate (Amlodipine benzenesulfonate) 是可口服的二氢吡啶钙通道阻滞剂,有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道,从而抑制钙离子内流,用于高血压和癌症的研究。 | |||
T15757 |
Limaprost
17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206 |
PGE Synthase | Immunology/Inflammation |
Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物,也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能,可用于疼痛的缓解,以及用于研究缺血性症状。 | |||
T31577 |
Droprenilamine
Valcor |
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Droprenilamine (Valcor) 是戊烯胺的脂环族衍生物,具有抗心绞痛作用。 | |||
T68853 |
Diproteverine HCl
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Diproteverine HCl 是具有抗心绞痛特性的新型钙拮抗剂,具有解痉活性和血管活性。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T0207 |
Ranolazine dihydrochloride
盐酸雷诺嗪,雷诺嗪二盐酸盐,RS 43285,Ranolazine 2HCl |
Calcium Channel; Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Ranolazine dihydrochloride (Ranolazine 2HCl) 是一种抗心绞痛和抗缺血剂,可通过抑制内向钠电流的后期作用来发挥功效,而不会影响心率或血压。它对 INa 和 IKr 的 IC50值分别为 6 μM 和 12 μM。它还是脂肪酸氧化的部分抑制剂。 | |||
T27183 |
Diproteverine
|
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Diproteverine is a calcium antagonist, it has antianginal property. | |||
T71021 |
Fendiline
|
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Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent. | |||
T15755 |
Lidoflazine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia. | |||
T26140 |
RS 5773
RS-5773,RS5773 |
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RS 5773 is a benzothiazepine derivative with antianginal effects. | |||
T12402L |
Penbutolol
HOE 893,l-Penbutolol,Levopenbutol,HOE 893D,Betapressin |
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Penbutolol is a nonselective beta-blocker utilized as an antihypertensive and an antianginal. | |||
T36723 |
Desmethyl Ranolazine
|
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Desmethyl ranolazine is a metabolite of the antianginal agent ranolazine .1It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A. 1.Wang, Y., Chen, X., Sun, Z., et al.Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasmaJ. Chromatogr. B889-89010-16(2012) | |||
T25691 |
Levamlodipine gentisate
(S)-Amlodipine gentisate,(S)-(-)-Amlodipine gentisate |
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Levamlodipine gentisate is a pharmacologically active enantiomer of amlodipine. Amlodipine is the dihydropyridine calcium channel blocker used as an antihypertensive and antianginal drug. | |||
TP1234 |
Amlodipine aspartic acid impurity
Amlodipine aspartate |
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Amlodipine aspartic acid is a calcium channel blocker compound that exhibits antihypertensive and antianginal properties. It is important to note that Amlodipine aspartic acid impurity is an impurity specific to this compound. | |||
T27302 |
Falipamil
AQ-A 39,AQ-A-39,AQ-A39 |
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Falipamil is a verapamil derivative and a calcium channel antagonist. Falipamil exerts antitachycardic effects by a direct action on the sinus node. Falipamil decreases HR at exercise in normal subjects and may exert antianginal effects in patients with m | |||
T29183 |
YM-430
YM-15430,YM-15430-1,YM-154301,YM-15430-2,YM430,YM-15430-3 |
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YM-430 is a β1 adrenergic receptor antagonist and a calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 n |