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Cat. No. | Product Name | Target | Signaling Pathways |
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T1489 |
Fosinopril sodium
SQ28555,福辛普利钠 |
RAAS | Endocrinology/Hormones |
Fosinopril sodium 是一种血管紧张素转换酶(ACE)抑制剂的前药,能够作用于高血压和慢性心力衰竭。 | |||
T1282 |
Carteolol hydrochloride
Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。 | |||
T15208 |
Elisartan
HN 65021 |
Others | Others |
Elisartan is a non-peptide pro-drug of angiotensin II AT1 receptor antagonist HN-12206. It also shows anti-hypertension activities. | |||
T35600 |
NO-Losartan A
|
||
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodi... | |||
T33673 |
Niludipine
Niludipina,BAY-a 7168,Bay a 7168,Niludipinum |
||
Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug | |||
T63445 |
Amlodipine mesylate
|
||
Amlodipine mesylate 是口服具有活力的二氢吡啶钙通道(calcium channel)阻滞剂,能够阻断电压依赖性的 L 型钙通道,并抑制钙离子内流,是一种抗心绞痛药。Amlodipine mesylate 能够用于研究高血压和癌症。 | |||
T80100 |
Ovotransferrin (328-332)
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Ovotransferrin (328-332) 在控制血压方面具有保护效果,主要通过抑制血管紧张素转换酶 (ACE) 实现,其抗ACE活性的IC50为20μM。此外,Ovotransferrin (328-332) 片段还能够抑制乙酰胆碱酯酶 (ChE),这是与阿尔茨海默病相关的特性。 | |||
T62618 | SPH3127 | ||
SPH3127 (DRI 18) 是一种强有效的、口服具有活力的、新型的 direct renin 抑制剂,其对 recombinant human-renin,human plasma renin activity 的 IC50 值分别为0.4 nM 和 0.45 nM。SPH3127具有抗高血压效果,能够用于研究高血压。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3055 |
Liensinine Perchlorate
|
Apoptosis; Others | Apoptosis; Others |
Liensinine Perchlorate 是元莲的成分,可诱导结直肠癌细胞凋亡,具有抗高血压和抗癌活性。 | |||
T3123 |
Allicin
|
ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection | Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome |
Allicin 具有抗氧化、杀菌、抗癌、抗炎活性,对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移,这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压,它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。 | |||
TN4323 |
Isorauhimbine
|
Antibiotic | Microbiology/Virology |
Isorauhimbine 是一种从萝芙藤 (R. serpentina) 中提取得到生物碱,具有抗癌、抗炎和抗菌活性,可用于治疗高血压、心律失常和心绞痛等心血管疾病。 |