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Search Results for " aminoglycoside "

29

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16073	Micronomicin 小诺霉素,Gentamicin C2b,Antibiotic XK-62-2,Sagamicin	Others; Antibacterial	Microbiology/Virology; Others
	Micronomicin (Gentamicin C2b) 是一种具有抗菌和杀菌能力的抗生素。
T1036	Netilmicin sulfate 硫酸奈替米星,Netillin,Certomycin,Netromycin,SCH-20569 (sulfate)	Antibacterial; Antibiotic	Microbiology/Virology
	Netilmicin sulfate (Netromycin) 是一种氨基糖苷类抗生素。
T6549	Isepamicin sulfate Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate	Antibacterial; Antibiotic	Microbiology/Virology
	Isepamicin sulfate (sch21420) Sulphate) 是一种广谱氨基糖苷类抗生素，对产生 I 型 6-乙酰转移酶的菌株具有良好的活性，通过靶向细菌 30S 核糖体亚基来抑制细菌蛋白质合成。
T2096	Framycetin sulfate Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate	Antibacterial; Antibiotic	Microbiology/Virology
	Framycetin sulfate (Neomycin Sulphate B) 是一种氨基糖苷类抗生素，是 RNase P 裂解活性抑制剂，Ki 为 35 μM。它抑制锤头状核酶，Ki 值为 13.5 μM，可用于肝性脑病和肠致病性大肠杆菌感染的研究。
T3125	Amikacin sulfate Amikacin Sulfate Salt,阿米卡霉素硫酸,硫酸阿米卡星	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Amikacin sulfate 是一种氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它抑制大多数革兰氏阴性细菌，还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T2211	Dihydrostreptomycin sulfate Dihydrostreptomycin sesquisulfate,双氢链霉索	Antibacterial; Antibiotic	Microbiology/Virology
	Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) 是一种氨基糖苷类抗生素，可研究牛、猪和羊的细菌性疾病。
T6382	Amikacin disulfate 硫酸阿米卡星,Pierami,阿米卡星硫酸盐,BAY-416651 sulfate,BB-K8,Amikacin sulfate	Antibacterial; Antibiotic	Microbiology/Virology
	Amikacin disulfate (BAY-416651 sulfate) 是氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它对大多数革兰氏阴性细菌都有效。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T21051	Arbekacin
	Arbekacin is an aminoglycoside antibiotic.
T26148	RU 25434 RU-25434,RU25434
	RU 25434 is a semi-synthetic aminoglycoside antibiotic.
T24649	Plazomicin
	Plazomicin is a next-generation aminoglycoside that has been designed as an antibiotic to avoid resistance through aminoglycoside-modifying enzymes. Plazomicin shows high activity against the Enterobacteriaceae.
T15348	Framycetin Fradiomycin B,新霉素B,Neomycin B	Others	Others
	Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).
T23952L	Dactimicin sulfate SF-2052 sulfate,Antibiotic SF 2052 sulfate
	Dactimicin is a new aminoglycoside. It also has in vitro activity, post-antibiotic effect, and interaction with other antibiotics.
T26534	AC 4437 AC4437,AC-4437
	AC 4437 is an aminoglycoside antibiotic.
T29105	Vertilmicin Sulfate vertilmicin
	Vertilmicin Sulfate, an aminoglycoside antibiotic, is used potentially for the treatment of bacterial infections.
T23952	Dactimicin ST 900,SF-2052
	Dactimicin is a novel pseudodisaccharide aminoglycoside. It has activities in vitro and in vivo antibacterial. Dactimicin was more resistant than astromicin to inactivation by aminoglycoside 3-acetyltransferase.
T26672	Astromicin Sulfate A-44747,A 44747,A44747
	Astromicin Sulfate is an antibiotic with aminoglycoside structure. Astromicin Sulfate may produce depression of neuromuscular function.
T0793L	Kanamycin A Kanamycin A,Kanamycine,Kantrex	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin is an aminoglycoside bacteriocidal antibiotic and used to treat a wide variety of infections. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes.
T64922	Kanamycin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Kanamycin 是氨基糖苷类杀菌抗生素，它通过与细菌30S 核糖体结合起作用。
T6383	Amikacin hydrate 阿米卡星水合物,BAY416651 hydrate	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Amikacin hydrate (BAY416651 hydrate) 是氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T73687	G-418
	G-418 (Geneticin)，一种氨基糖苷类抗生素，其结构与庆大霉素相似，既对真核细胞也对原核细胞具有毒性，主要通过干扰蛋白质合成发挥作用。
T40662	Isepamicin Sch 21420
	Isepamicin (Sch 21420) is a potent aminoglycoside antibacterial compound with enhanced efficacy against strains harboring type I 6'-acetyltransferase. Its antibacterial spectrum encompasses Enterobacteriaceae and staphylococci, while exhibiting resistance against anaerobes, Neisseriaceae, and streptococci. Moreover, Isepamicin displays a robust concentration-dependent bactericidal effect, a prolonged post-antibiotic effect lasting several hours, and is capable of inducing adaptive resistance.
T38303	Apramycin (Nebramycin II)
	Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A bas...
T75299	Etimicin sulfate
	Etimicin (sulfate)是第四代氨基糖苷类抗生素，因其高效、低毒而被广泛应用于临床。
T36182	Neamine tetrahydrochloride
	Neamine tetrahydrochloride 是一种广谱氨基糖苷类抗生素，一种新霉素的降解产物。Neamine tetrahydrochloride 可通过靶向血管生成素 (angiogenin) 发挥抗血管生成作用。Neamine tetrahydrochloride 具有抗菌，抗肿瘤和神经保护活性。
T75667	Neamine
	Neamine，新霉素降解产物，为广谱氨基糖苷类抗生素。作为抗血管生成剂，针对血管生成素 (angiogenin)，展现抗菌、抗肿瘤及神经保护活性。
T73953	Neomycin C
	Neomycin C是新霉素复合物中的两个主要活性异构体之一，为含2-DOS的氨基糖苷复合物，包括neomycin A，neomycin B以及neomycin C。其活性仅为Neomycin B的一半。
T61306	SRI-41315
	SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop codons, resulting in the restoration of cystic fibrosis transmembrane conductance regulator (CFTR) expression and function. This compound achieves PTC suppression by reducing the abundance of the termination factor eRF1. Additionally, SRI-41315 synergistically enhances CFTR acti...
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...
T37901	UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)
	UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K.,...

化合物

Cat.No: T16073

Synonym: 小诺霉素,Gentamicin C2b,Antibiotic XK-62-2,Sagamicin

Target: Others, Antibacterial

Netilmicin sulfate

Cat.No: T1036

Synonym: 硫酸奈替米星,Netillin,Certomycin,Netromycin,SCH-20569 (sulfate)

Target: Antibacterial, Antibiotic

Isepamicin sulfate

Cat.No: T6549

Synonym: Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate

Target: Antibacterial, Antibiotic

Framycetin sulfate

Cat.No: T2096

Synonym: Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate

Target: Antibacterial, Antibiotic

Amikacin sulfate

Cat.No: T3125

Synonym: Amikacin Sulfate Salt,阿米卡霉素硫酸,硫酸阿米卡星

Target: ribosome, Antibacterial, Antibiotic

Dihydrostreptomycin sulfate

Cat.No: T2211

Synonym: Dihydrostreptomycin sesquisulfate,双氢链霉索

Target: Antibacterial, Antibiotic

Amikacin disulfate

Cat.No: T6382

Synonym: 硫酸阿米卡星,Pierami,阿米卡星硫酸盐,BAY-416651 sulfate,BB-K8,Amikacin sulfate

Target: Antibacterial, Antibiotic

Cat.No: T21051

Cat.No: T26148

Synonym: RU-25434,RU25434

Cat.No: T24649

Cat.No: T15348

Synonym: Fradiomycin B,新霉素B,Neomycin B

Target: Others

Dactimicin sulfate

Cat.No: T23952L

Synonym: SF-2052 sulfate,Antibiotic SF 2052 sulfate

Cat.No: T26534

Synonym: AC4437,AC-4437

Vertilmicin Sulfate

Cat.No: T29105

Synonym: vertilmicin

Cat.No: T23952

Synonym: ST 900,SF-2052

Astromicin Sulfate

Cat.No: T26672

Synonym: A-44747,A 44747,A44747

Cat.No: T0793L

Synonym: Kanamycin A,Kanamycine,Kantrex

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T64922

Target: ribosome, Antibacterial, Antibiotic

Amikacin hydrate

Cat.No: T6383

Synonym: 阿米卡星水合物,BAY416651 hydrate

Target: Others, Antibacterial, Antibiotic

Cat.No: T73687

Cat.No: T40662

Synonym: Sch 21420

Apramycin (Nebramycin II)

Cat.No: T38303

Etimicin sulfate

Cat.No: T75299

Neamine tetrahydrochloride

Cat.No: T36182

Cat.No: T75667

Cat.No: T73953

Cat.No: T61306

Paromomycin, sulfate (1:1)

Cat.No: T65387

UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)

Cat.No: T37901

Cat. No.	Product Name	Target	Signaling Pathways
T0950	Neomycin sulfate Framycin sulfate,硫酸新霉素	Phospholipase; ribosome; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology
	Neomycin sulfate (Framycin sulfate) 是一种广谱的氨基糖苷类抗生素。Neomycin sulfate 可以阻断细菌蛋白质的合成以发挥抗菌活性。Neomycin sulfate 常用于筛选具有 Neo 抗性基因的原核和真核细胞。
T0793	Kanamycin sulfate 硫酸卡那霉素,Kanamycin monosulfate,Kanamycin A monosulfate,Ophtalmokalixan	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Kanamycin sulfate (Kanamycin monosulfate) 是氨基糖苷类杀菌抗生素，它通过与细菌30S 核糖体结合起作用。
T1219	Sisomicin Sulfate 硫酸西索米星,Pathomycin,Extramycin,硫酸西索紫苏	Antibacterial; Antibiotic	Microbiology/Virology
	Sisomicin Sulfate (Pathomycin) 是由Micromonospora inyoensis 产生的一种广谱氨基糖苷类抗生素，对革兰氏阳性细菌有很大活性。
T8118	Bekanamycin Kanamycin B,卡那霉素,卡那霉素 B	Antibacterial; Antibiotic	Microbiology/Virology
	Bekanamycin (Kanamycin B) 是一种提取自 Streptomyces kanamyceticus 的氨基糖苷类抗生素，抑制一系列革兰氏阳性和阴性细菌。
T1084	Apramycin sulfate Nebramycin II,Ai3-29795,硫酸安普霉素,硫酸阿布拉霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Apramycin sulfate (Nebramycin II) 是一种由黑暗链霉菌产生的兽用氨基糖苷类抗生素。
T1326	Gentamicin sulfate SCH9724,Gentamycin sulfate,NSC-82261,硫酸庆大霉素	ribosome; DHFR; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Gentamicin sulfate (SCH9724) 是一种广谱氨基糖苷类抗生素，用于抑制敏感生物体中的蛋白质合成。
T1255	Tobramycin NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
T1022	Hygromycin B 潮霉素B,Hygrovetine	ribosome; Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Hygromycin B (Hygrovetine) 是一种氨基糖苷类抗生素，通过干扰易位并导致 70S 核糖体的错误翻译来抑制蛋白质合成。Hygromycin B 可用于筛选转染 hph 或 hyg 抗性基因的原核或者真核细胞。
T6512	G-418 disulfate Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate	Antibacterial; Antibiotic	Microbiology/Virology
	G-418 disulfate (Geneticin sulfate) 属于氨基糖苷类抗生素，是一种蛋白质合成的抑制剂，具有真核细胞选择性。G-418 disulfate 通过抑制肽链的延伸来阻断多肽合成。
T1214	Ribostamycin sulfate Vistamycin sulfate,硫酸核糖霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Ribostamycin sulfate (Vistamycin sulfate) 是一种广谱抗菌剂, 在30S 和50S 核糖体亚基结合抑制细菌蛋白质合成, 还抑制蛋白二硫键异构酶分子伴侣活性, 用于药代动力学和肾毒性研究。
T2762	Kasugamycin hydrochloride Kasumin,盐酸春雷霉素	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Kasugamycin hydrochloride (Kasumin) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸以破坏 tRNA 结合并抑制经典翻译起始。
T20675	Sisomicin Rickamicin,Siseptin
	Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.
T74207	Ribostamycin
	Ribostamycin (Vistamycin) 是一种广谱氨基糖苷类抗生素 (antibiotic)。Ribostamycin 对革兰氏阴性和革兰氏阳性细菌感染有效。Ribostamycin 还抑制PDI 的伴侣活性。
T1104	Paromomycin Sulfate Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素，是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。它可研究细菌和寄生虫感染。

天然产物

Neomycin sulfate

Cat.No: T0950

Synonym: Framycin sulfate,硫酸新霉素

Target: Phospholipase, ribosome, Antibacterial, Antibiotic

Kanamycin sulfate

Cat.No: T0793

Synonym: 硫酸卡那霉素,Kanamycin monosulfate,Kanamycin A monosulfate,Ophtalmokalixan

Target: ribosome, Antibacterial, Antibiotic

Sisomicin Sulfate

Cat.No: T1219

Synonym: 硫酸西索米星,Pathomycin,Extramycin,硫酸西索紫苏

Target: Antibacterial, Antibiotic

Cat.No: T8118

Synonym: Kanamycin B,卡那霉素,卡那霉素 B

Target: Antibacterial, Antibiotic

Apramycin sulfate

Cat.No: T1084

Synonym: Nebramycin II,Ai3-29795,硫酸安普霉素,硫酸阿布拉霉素

Target: Antibacterial, Antibiotic

Gentamicin sulfate

Cat.No: T1326

Synonym: SCH9724,Gentamycin sulfate,NSC-82261,硫酸庆大霉素

Target: ribosome, DHFR, Antibacterial, Antibiotic

Cat.No: T1255

Synonym: NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B

Target: ribosome, Antibacterial, Antibiotic

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T1022

Synonym: 潮霉素B,Hygrovetine

Target: ribosome, Antibacterial, Antibiotic, Antifungal

G-418 disulfate

Cat.No: T6512

Synonym: Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate

Target: Antibacterial, Antibiotic

Ribostamycin sulfate

Cat.No: T1214

Synonym: Vistamycin sulfate,硫酸核糖霉素

Target: Antibacterial, Antibiotic

Kasugamycin hydrochloride

Cat.No: T2762

Synonym: Kasumin,盐酸春雷霉素

Target: Antibacterial, Antibiotic, Antifungal

Cat.No: T20675

Synonym: Rickamicin,Siseptin

Cat.No: T74207

Paromomycin Sulfate

Cat.No: T1104

Synonym: Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐

Target: Antibacterial, Antibiotic, Parasite

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