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27

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25180	Bromodiphenhydramine hydrochloride	Others	Others
	Bromodiphenhydramine hydrochloride 是一种控制皮肤的新型抗组胺药。
T3267	Potassium guaiacolsulfonate hemihydrate 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾	Antibacterial; Antibiotic	Microbiology/Virology
	Potassium guaiacolsulfonate hemihydrate (Potassium guaiacolsulfonate) 是一种芳香族磺酸，在医药中用作祛痰剂，可治疗急性呼吸道感染。它可松弛粘液，与其他药物合用，可治疗普通感冒、感染或过敏引起的咳嗽。
T24451	Mepyramine NSC-13136,NSC13136,NSC 13136
	Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies both parenterally and locally.
T0113	Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。
T67815	uk-50001	PDE	Metabolism
	uk-50001是一种磷酸二酯酶(PDE4) 4抑制剂，可用于许多疾病，特别是炎症、过敏、呼吸系统疾病、失调和病症以及伤口。
T4563	Thonzylamine neohetramine,松齐拉敏	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂，具有抗组胺和抗过敏特性，可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。
T21419	Diphenhydramine 苯海拉明,Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Diphenhydramine (Syntedril) 是第一代具有抗胆碱能作用的H1 受体拮抗剂，它能透过血脑屏障。
T1232	Mepyramine maleate 马来酸吡纳明,Pyrilamine maleate,吡拉明马来酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mepyramine maleate (Pyrilamine maleate) 是一种组胺 H1 拮抗剂，对 H1、H2 和 H3 受体的 Kd 值分别为 0.8、5200 和大于 3000 nM，对 H1 受体的 pKd 值为 9.4。它是感冒药的常见成分，具有温和的催眠特性和局部麻醉作用，可用于胃肠外和局部过敏。
T69026	Clemizole penicillin
	Clemizole penicillin is a histamine H1- blocker used to treat allergies.
T69501	Montelukast alcohol
	Montelukast alcohol is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T38623	Ifidancitinib ATI-502,ATI-50002
	Ifidancitinib, a potent and selective inhibitor of JAK kinases 1/3, is utilized in the research of allergies, asthma, and autoimmune diseases.
T71369	Montelukast sulfoxide
	Montelukast sulfoxide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T68496	Montelukast cyclopropaneacetamide
	Montelukast cyclopropaneacetamide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T68295	Montelukast methyl ketone
	Montelukast methyl ketone is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T68348	Montelukast methylstyrene
	Montelukast methylstyrene is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T71152	Montelukast bis-sulfide
	Montelukast bis-sulfide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
T69434	Methapyrilene fumarate
	Methapyrilene fumarate is a histamine H1 antagonist with sedative action used as a hypnotic and in allergies. It is a hepatocarcinogen in sufficiently high doses, inducing mutations through an indirect genotoxic mechanism; e.g., via an oxidative mechanism or interaction with chromosomal proteins.
T33978	Phenindamine Tartrate Pernovine,Thephorin,Nolahist,Phenindamine,Plegine
	Phenindamine Tartrate is an antihistamine and anticholinergic drug closely related to cyproheptadine. It is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives.
T21462	Olopatadine Opatanol,Patanol,KW-4943A,KW-4679
	Olopatadine, an antihistamine, as well as anticholinergic and mast cell stabilizer, is used for the treatment of itching associated with allergic conjunctivitis (eye allergies). There is also a potential for Olopatadine to treat steroid rebound (red skin
T21074	Dexamethasone acetate Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron
	Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics
T82730	Cholesterylamine
	Cholesterylamine是一种阳离子脂质，常用于药物递送领域，同时在自身免疫性疾病和过敏的研究中也有应用。
T36315	NVS-PI3-4 NVS-PI3-4
	NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2].
T40430	Cetirizine Impurity D
	Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies.
T69918	Adriforant tartrate hydrate
	Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies.
T68280	Adriforant
	Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies.
T78291	Tregalizumab BT-061
	Tregalizumab为人源化抗CD4单克隆抗体（IgG1型），体外能选择性激活调节性T细胞（Tregs）功能。适用于研究自身免疫性疾病（因Treg功能不足）及过敏反应。
T61013	Bromodiphenhydramine
	Bromodiphenhydramine 具有抗菌活性，可用于皮肤过敏研究。它是一种有效的抗组胺剂，并且可以抑制大量的革兰氏阴性和革兰氏阳性细菌。

化合物

Bromodiphenhydramine hydrochloride

Cat.No: T25180

Target: Others

Potassium guaiacolsulfonate hemihydrate

Cat.No: T3267

Synonym: 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾

Target: Antibacterial, Antibiotic

Cat.No: T24451

Synonym: NSC-13136,NSC13136,NSC 13136

Mebhydrolin napadisylate

Cat.No: T0113

Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline

Target: 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T67815

Target: PDE

Cat.No: T4563

Synonym: neohetramine,松齐拉敏

Target: Histamine Receptor

Diphenhydramine

Cat.No: T21419

Synonym: 苯海拉明,Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255

Target: Histamine Receptor

Mepyramine maleate

Cat.No: T1232

Synonym: 马来酸吡纳明,Pyrilamine maleate,吡拉明马来酸盐

Target: Histamine Receptor

Clemizole penicillin

Cat.No: T69026

Montelukast alcohol

Cat.No: T69501

Cat.No: T38623

Synonym: ATI-502,ATI-50002

Montelukast sulfoxide

Cat.No: T71369

Montelukast cyclopropaneacetamide

Cat.No: T68496

Montelukast methyl ketone

Cat.No: T68295

Montelukast methylstyrene

Cat.No: T68348

Montelukast bis-sulfide

Cat.No: T71152

Methapyrilene fumarate

Cat.No: T69434

Phenindamine Tartrate

Cat.No: T33978

Synonym: Pernovine,Thephorin,Nolahist,Phenindamine,Plegine

Cat.No: T21462

Synonym: Opatanol,Patanol,KW-4943A,KW-4679

Dexamethasone acetate

Cat.No: T21074

Synonym: Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron

Cholesterylamine

Cat.No: T82730

Cat.No: T36315

Synonym: NVS-PI3-4

Cetirizine Impurity D

Cat.No: T40430

Adriforant tartrate hydrate

Cat.No: T69918

Cat.No: T68280

Cat.No: T78291

Synonym: BT-061

Bromodiphenhydramine

Cat.No: T61013

Cat. No.	Product Name	Target	Signaling Pathways
T5802	Stearyl glycyrrhetinate	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Stearyl glycyrrhetinate 是甘草提取物中的主要成分之一，具有抗菌作用，对金黄色葡萄球菌菌株的 MIC 大于 256 mg/L。
TN3062	4'-O-Methylnyasol	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
TN4683	Nyasol	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly

天然产物

Stearyl glycyrrhetinate

Cat.No: T5802

Target: Antiviral, Antibacterial

4'-O-Methylnyasol

Cat.No: TN3062

Target: Histamine Receptor

Cat.No: TN4683

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

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