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31

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc...
T13172L1	TMP-778	ROR	Metabolism
	TMP-778是一种RORγt 的选择性逆向激动剂。
T13174	TMPyP4 tosylate TMP 1363	DNA/RNA Synthesis; Telomerase	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体，抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂，在骨肉瘤细胞系中显示抗肿瘤作用。
T3983	TMP195 TFMO 2,TMP 195	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP195 (TFMO 2) 是一种选择性 IIa 类组蛋白脱乙酰酶 (HDAC) 抑制剂。对 HDAC4、HDAC5、HDAC7，HDAC9的 Ki 值分别为59、60、26，5 nM。
T1857	TMP269	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP269 是一种有效的特异性 IIa 类 HDAC 抑制剂，分别抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC50值分别为 157 nM，97 nM，43 nM 和 23 nM。
T31017	Coumarin-TMP-Halo Coumarin TMP Halo,CTH
	Coumarin-TMP-Halo is a specific fluorescent protein labeling agent.
T34893	TMP-NVOC-Halo TNH
	TMP-NVOC-Halo is a caged protein labeling agent.
T80972	TNH TMP-NVOC linker-Halo
	TNH为一种二聚体，能够渗透活细胞并招募蛋白质至细胞结构。
T78534	NVOC cage-TMP-Halo	Others	Others
	NVOC cage-TMP-Halo是一种具有细胞渗透能力和光激活特性的蛋白质二聚化诱导剂。该化合物可对活细胞内蛋白质定位进行快速且可逆的控制，适用于研究动态细胞过程。
T24899	Trimosulfa Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa
	Trimosulfa is a fixed antibiotic combination that widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.
T13172L	TMP778	Others	Others
	TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).
T17108	TMP920	ROR	Metabolism
	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T13172	TMP780	ROR	Metabolism
	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T83821	Thymidine-5'-O-(α,β-methylene)diphosphate sodium α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP
	TMP-CP（Thymidine-5’-O-(α,β-methylene)diphosphate）是TDP的一种水解稳定衍生物，同时也是一种thymidine kinase抑制剂（Ki = 23 µM）。它已被用作α,β-methylene-2’-deoxythymidine 5’-triphosphate合成的前体，该合成物是DNA polymerase的一种不可切割底物。
T40732	TMPD dihydrochloride
	TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。
T13173	TMPA	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。
T60080	TMPH 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR	Neuroscience
	TMPH 是一种 nAChR 抑制剂，可抑制缺乏 α5、α6 或 β3 亚基的 nAChR。 TMPH 可用于关于 nAChR 功能障碍或神经系统疾病的研究。
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory activity against tyrosinase. Furthermore, MtTMPK-IN-4 exhibits potent antibacterial properties [1] [2].
T63657	MtTMPK-IN-9
	MtTMPK-IN-9 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂 (IC50: 48 μM)。MtTMPK-IN-9 对抗分枝杆菌具有亚微摩尔活性，但没有显著的细胞毒性。MtTMPK-IN-9 能够用于研究结核病。
T63491	MtTMPK-IN-8
	MtTMPK-IN-8 是具有中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂，没有显著的细胞毒性，对抗分枝杆菌表现出亚微摩尔活性 (MICs = 0.78~9.4 μM)，能够用于研究结核病。
T78238	4′-DTMP 4-Demethyltrimethoprim	DHFR; Antifungal	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	4′-DTMP (4-Demethyltrimethoprim) 是一种有效的 DHFR 抑制剂，具有抗菌活性，诱导与酶的额外局部相互作用，对大肠杆菌具有抑制作用。
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T61781	MtTMPK-IN-6
	MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T62305	MtTMPK-IN-2
	MtTMPK-IN-2 (compound 15)为一高效MtbTMPK抑制剂，IC50值达1.1 μM。该化合物对MtbH37Rv表现出抑制活性（MIC = 12.5 μM），同时对人成纤维细胞MRC-5显示出一定细胞毒性（EC50= 6.1 μM）。MtTMPK-IN-2适用于结核病研究。
T61796	MtTMPK-IN-1
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demonstrating low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 is a valuable tool for tuberculosis research [1].
T63639	MtTMPK-IN-7
	MtTMPK-IN-7 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK) 抑制剂 (IC50: 47 μM)。MtTMPK-IN-7 对抗分枝杆菌表现出亚微摩尔活性，其 MICs 值为 2.3~4.7 μM。MtTMPK-IN-7 能够用于研究结核病。
T61573	MtTMPK-IN-5
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T35966	Mn(III)TMPyP
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, re...
T28986	TMPPAA
	TMPPAA is an allosteric agonist of 5-HT3 receptor.
T23462	TMPH hydrochloride	Others	Others
	neuronal nicotinic ACh receptors (nAChRs) antagonist
T62897	MtTMPK-IN-3
	MtTMPK-IN-3（compound 25）是一种针对结核分枝杆菌胸苷酸激酶（MtbTMPK）的有效抑制剂，具有0.12 μM的IC50值。该化合物对MtbH37Rv展示出了抑制效果（MIC=12.5 μM），同时对人成纤维细胞MRC-5显示出一定的细胞毒性（EC50=12.5 μM）。MtTMPK-IN-3适用于结核病研究领域。

化合物

Cat.No: T36126

Cat.No: T13172L1

Target: ROR

TMPyP4 tosylate

Cat.No: T13174

Synonym: TMP 1363

Target: DNA/RNA Synthesis, Telomerase

Cat.No: T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

Cat.No: T1857

Target: HDAC

Coumarin-TMP-Halo

Cat.No: T31017

Synonym: Coumarin TMP Halo,CTH

TMP-NVOC-Halo

Cat.No: T34893

Synonym: TNH

Cat.No: T80972

Synonym: TMP-NVOC linker-Halo

NVOC cage-TMP-Halo

Cat.No: T78534

Target: Others

Cat.No: T24899

Synonym: Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa

Cat.No: T13172L

Target: Others

Cat.No: T17108

Target: ROR

Cat.No: T13172

Target: ROR

Thymidine-5'-O-(α,β-methylene)diphosphate sodium

Cat.No: T83821

Synonym: α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP

TMPD dihydrochloride

Cat.No: T40732

Cat.No: T13173

Target: Others, AMPK

Cat.No: T60080

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Target: AChR

Cat.No: T61780

Cat.No: T63657

Cat.No: T63491

Cat.No: T78238

Synonym: 4-Demethyltrimethoprim

Target: DHFR, Antifungal

Cat.No: T27314

Cat.No: T61781

Cat.No: T62305

Cat.No: T61796

Cat.No: T63639

Cat.No: T61573

Cat.No: T35966

Cat.No: T28986

TMPH hydrochloride

Cat.No: T23462

Target: Others

Cat.No: T62897

Cat. No.	Product Name	Target	Signaling Pathways
T4730	Thymidine-5'-monophosphate disodium salt 胸苷酸二钠,Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT	Others; Endogenous Metabolite	Metabolism; Others
	Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) 是内源性代谢产物的一种。
T4558	Trioxsalen 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物，与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂，可用于激光激活定位的基因组链间交联可视化。
T7892	ATMP	Others	Others
	ATMP 是一种具有螯合特性的膦酸。它是一种阻垢剂。
T0572	Methyl 3,4,5-trimethoxybenzoate Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,甲氧苄啶杂质H,Trimethylgallic acid methyl ester	Others	Others
	Methyl 3,4,5-trimethoxybenzoate (Methyl EudesMate) 是由 Gallic acid 为原料合成得到，常用于生产磺胺增效剂中间体、甲氧苄氨嘧啶 (TMP)以及许多其它药物。
T83320	4'-Demethylpodophyllotoxone
	4'-Demethylpodophyllotoxone为链格孢（Alternaria alternata）S-f6的生物转化中间产物，经4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP)修饰后形成的新化合物，可有效抑制人胃癌细胞系（BGC-823）的生长。
T75540	Ipomoeassin F
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。

天然产物

Thymidine-5'-monophosphate disodium salt

Cat.No: T4730

Synonym: 胸苷酸二钠,Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT

Target: Others, Endogenous Metabolite

Cat.No: T4558

Synonym: 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

Cat.No: T7892

Target: Others

Methyl 3,4,5-trimethoxybenzoate

Cat.No: T0572

Synonym: Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,甲氧苄啶杂质H,Trimethylgallic acid methyl ester

Target: Others

4'-Demethylpodophyllotoxone

Cat.No: T83320

Cat.No: T75540

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