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Targets Recommended: CDK Ligand for E3 Ligase

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T34888	TL12-186 TL12 186,TL12186	CDK; Ligand for E3 Ligase	Cell Cycle/Checkpoint; PROTAC
	TL12-186 是一种依赖于 Cereblon 的激酶降解剂，可降解 CDK，BTK，FLT3，Aurora 等激酶。TL12-186 对 CDK2/cyclin A 和 CDK9/cyclin T1 有抑制作用，IC50 分别为 73 和 55 nM。
T13017	STL127705 Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 为 3.5 μM。它抑制 Ku 依赖性 DNA-PKCS 激酶的激活，IC50 为 2.5 μM。
T27560	HTL14242 HTL 14242,HTL-14242
	HTL14242 is a mGlu5 Negative Allosteric Modulator.
T37083	TL13-110 TL 13-110
	Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM). Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase. J.Med.Chem. 61 4249 PMID:29660984
T34889	TL13-149 TL13149,TL13 149
	TL13-149 is an AC220-based FLT3 degrader.
T13929	TL13-112	Others	Others
	TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
T37084	TL13-22 TL 13-22
	Negative control for TL 13-12 . Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM) Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
T34890	TL13-27 TL13 27
	TL13-27 is a negative control for TL12-186.
T13930	TL13-12	Others	Others
	TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
T73443	STL1267
	STL1267 是一种有效的可穿过血脑屏障的REV-ERB 激动剂，对 REV-ERBα 的Ki 值为 0.16 µM。STL1267 没有表现出细胞毒性。STL1267 抑制 BMAL1 的基因表达。

化合物

TL12-186

Cat.No: T34888

Synonym: TL12 186,TL12186

Target: CDK, Ligand for E3 Ligase

STL127705

Cat.No: T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

HTL14242

Cat.No: T27560

Synonym: HTL 14242,HTL-14242

Target:

TL13-110

Cat.No: T37083

Synonym: TL 13-110

Target:

TL13-149

Cat.No: T34889

Synonym: TL13149,TL13 149

Synonym: TL 13-22

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04645	TL1A/TNFSF15 Protein, Human, Recombinant (hFc) TL1,tumor necrosis factor (ligand) superfa...	Human	HEK293 Cells
	TL1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is A0A0U5JA19.
TMPJ-00603	TL1A/TNFSF15 Protein, Mouse, Recombinant TNFSF15,Tumor Necrosis Factor Ligand Superfamily Me...	Mouse	E. coli
	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ...
TMPK-01012	TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated TL1,TNFSF15,VEGI,VEGI-251	Mouse	HEK293 Cells
	TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 kDa and the accession number is Q5UBV8.
TMPK-01011	TL1A/TNFSF15 Protein, Mouse, Recombinant (His & Avi) TNFSF15,VEGI-251,TL1A,VE...	Mouse	HEK293 Cells
	TNFSF15 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.40 kDa and the accession number is Q5UBV8.
TMPK-00143	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) TL1A,TL1,TNFSF1...	Human	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight...
TMPK-01013	TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc) VEGI192A,TL1,VEGI-251,	Mouse	HEK293 Cells
	TNFSF15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 48.8 kDa and the accession number is Q5UBV8.
TMPY-04978	TL1A/TNFSF15 Protein, Human, Recombinant (rFc) VEGI,VEGI192A,TL1,TL...	Human	HEK293 Cells
	TL1A Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 48 kDa and the accession number is A0A0U5JA19.
TMPY-05802	TL1A/TNFSF15 Protein, Human, Recombinant (His) TL1A,VEGI,VEGI192A,tumor necrosis...	Human	HEK293 Cells
	TL1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is A0A0U5JA19.
TMPY-04979	TL1A/TNFSF15 Protein, Human, Recombinant (mFc) VEGI,tumor necrosis factor (ligand) superfamily, member ...	Human	HEK293 Cells
	TL1A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 47.1 kDa and the accession number is A0A0U5JA19.
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) TNFSF15,TNF superfamily member 15,TL	Cynomolgus,Rhesus	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPY-01661	METTL1 Protein, Human, Recombinant (His) methyltransferase like 1,TRMT8,TRM8,YDL201...	Human	E. coli
	tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. METTL1 gene has been identified by its sequence similarity to the yeast ORF YDL21w. The human cDNA and the genomic structure of METTL1 have been analyzed. The transcript contains 1292 nucleotides and codes for a protein of 276 amino acids. The METTL1 gene product shows high sequen...
TMPY-01106	FSTL1 Protein, Human, Recombinant (His) MIR198,FSL1,follistatin-like 1,FR...	Human	HEK293 Cells
	FSTL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is Q12841-1.
TMPY-01285	METTL11A Protein, Human, Recombinant C9orf32,METTL11A,NTM1A,N...	Human	E. coli
	METTL11A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.5 kDa and the accession number is A0A024R8E4.
TMPJ-00191	FSTL1 Protein, Human, Recombinant FRP,Follistatin-Related Protein 1,Follistatin-Like ...	Human	E. coli
	Follistatin-Related Protein 1 (FSTL1) is a secreted protein that contains two EF-hand domains, one follistatin-like domain, one Kazal-like domain, and one VWFC domain. Its functional significance in physiological and pathological processes is not completely understood. However, FSTL1 is thought to modulate the action of some growth factors on cell proliferation and differentiation. FSTL1 maybe an autoantigen associated with rheumatoid arthritis.
TMPJ-01223	GALNTL1 Protein, Human, Recombinant (His) UDP-GalNAc:Polypeptide N-,Polypeptide GalNAc Transferase-Lik...	Human	HEK293 Cells
	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1, also known as Polypeptide GalNAc transferase-like protein 1, Protein-UDP acetylgalactosaminyltransferase-like protein 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1, GalNAC-T-like protein 1, pp-GaNTase-like protein 1 and GALNTL1, belongs to the glycosyltransferase 2 family. GALNTL1 plays an important role in the protein modification and protein glycosylation process. GALNTL1 uses the manganese and ...
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc) CYTL1,C4orf4,Protein C17	Mouse	HEK293 Cells
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 is expressed by a sub-population of CD34 human mononuclear cells from bone marrow and cord blood, and by chondrocytes (cartilage-forming cells).
TMPY-01284	METTL11A Protein, Human, Recombinant (GST) C9orf32,AD-003,METTL11A,HOMT1...	Human	E. coli
	METTL11A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A024R8E4.
TMPY-04210	CSTL1 Protein, Human, Recombinant (hFc) RCET11,cystatin-like 1,CTES1<...	Human	HEK293 Cells
	CSTL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is AAI17397.1.
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc) angiopoietin-like 1	Canine	HEK293 Cells
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre...
TMPY-02556	FSTL1 Protein, Mouse, Recombinant (His) AW107808,follistatin-like 1,Fstl,...	Mouse	HEK293 Cells
	FSTL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.9 kDa and the accession number is Q62356.
TMPY-00613	FSTL1 Protein, Mouse, Recombinant (hFc) AW107808,AI316791,TSC-36,Fstl...	Mouse	HEK293 Cells
	FSTL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59.5 kDa and the accession number is Q62356.
TMPY-03067	TL1A/TNFSF15 Protein, Rat, Recombinant (hFc) tumor necrosis factor (ligand) superfamily, member 1	Rat	HEK293 Cells
	TL1A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q8K3Y7.
TMPY-00044	CYTL1 Protein, Human, Recombinant (mFc) C4orf4,C17,cytokine-like 1	Human	HEK293 Cells
	Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first identified in CD34(+) cells derived from bone marrow and cord blood, and it was also found using our immunogenomics strategy. CYTL1 expression appears to be highest in the hematopoietic system and in chondrocytes; however, maintenance of cartilage in mouse models of arthritis is ...

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